Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Xiaokuang Ma"'
Autor:
Lei Shen, Xiaokuang Ma, Yuanyuan Wang, Zhihao Wang, Yi Zhang, Hoang Quoc Hai Pham, Xiaoqun Tao, Yuehua Cui, Jing Wei, Dimitri Lin, Tharindumala Abeywanada, Swanand Hardikar, Levon Halabelian, Noah Smith, Taiping Chen, Dalia Barsyte-Lovejoy, Shenfeng Qiu, Yi Xing, Yanzhong Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Protein arginine methyltransferase 9 (PRMT9) is a recently identified member of the PRMT family, yet its biological function remains largely unknown. Here, by characterizing an intellectual disability associated PRMT9 mutation (G189R) and es
Externí odkaz:
https://doaj.org/article/9ca62f8e33764e4fab27f52e88be7a63
Autor:
Xiaokuang Ma, Peng Chen, Jing Wei, John Zhang, Chang Chen, Hanqiu Zhao, Deveroux Ferguson, Aaron W. McGee, Zhiyu Dai, Shenfeng Qiu
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103420- (2024)
Summary: Here, we present a protocol for Xenium spatial transcriptomics studies using fixed frozen mouse brain sections. We describe steps for intracardiac perfusion, cryosectioning, and floating section mounting of brain sections, which enable runs
Externí odkaz:
https://doaj.org/article/4ee6e2e22bb14788add2f91755d4928f
Autor:
Yuehua Cui, Xiaokuang Ma, Jing Wei, Chang Chen, Neha Shakir, Hitesch Guirram, Zhiyu Dai, Trent Anderson, Deveroux Ferguson, Shenfeng Qiu
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1431-1444 (2025)
Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration, however, few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function. We have previously shown th
Externí odkaz:
https://doaj.org/article/5675538ec13c4b989f93751292041a96
Autor:
Chang Chen, Xiaokuang Ma, Jing Wei, Neha Shakir, Jessica K. Zhang, Le Zhang, Antoine Nehme, Yuehua Cui, Deveroux Ferguson, Feng Bai, Shenfeng Qiu
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Genetic risk factors for neurodegenerative disorders, such as Alzheimer’s disease (AD), are expressed throughout the life span. How these risk factors affect early brain development and function remain largely unclear. Analysis of animal m
Externí odkaz:
https://doaj.org/article/971a6cddfada4a63acec203c0ae3690d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer's disease (AD) is a neurodegenerative disorder strongly associates with aging. While amyloid plagues and neurofibrillary tangles are pathological hallmarks of AD, recent evidence suggests synaptic dysfunction and physical loss may be the ke
Externí odkaz:
https://doaj.org/article/bb3de869a8e3437aa7d158b8d208b2f9
Autor:
Zegang Ma, Fenfei Gao, Brett Larsen, Ming Gao, Zhihua Luo, Dejie Chen, Xiaokuang Ma, Shenfeng Qiu, Yu Zhou, Junxia Xie, Zheng-Xiong Xi, Jie Wu
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 225-237 (2019)
Background: We have recently reported that activation of cannabinoid type 2 receptors (CB2Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA). Here, we elucidate the underlying mechanisms. Methods: Patch-clamp recordin
Externí odkaz:
https://doaj.org/article/1108c50b81b34c0fbaedec3da0dccecd
Autor:
Guanqun Huang, Shuting Chen, Xiaoxia Chen, Jiajun Zheng, Zhuoran Xu, Abolfazl Doostparast Torshizi, Siyi Gong, Qingpei Chen, Xiaokuang Ma, Jiandong Yu, Libing Zhou, Shenfeng Qiu, Kai Wang, Lingling Shi
Publikováno v:
Frontiers in Neuroanatomy, Vol 13 (2019)
SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/ad0d3c36eb624333894f1743b9b65e42
Autor:
Dejie Chen, Fenfei Gao, Xiaokuang Ma, Jason Brek Eaton, Yuanbing Huang, Ming Gao, Yongchang Chang, Zegang Ma, Taleen Der-Ghazarian, Janet Neisewander, Paul Whiteaker, Jie Wu, Quanxi Su
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocain
Externí odkaz:
https://doaj.org/article/4d6174846d8b4b2484b679a00ec94fe7
Autor:
Bret R. Tallent, Shenfeng Qiu, J. Bryce Ortiz, Xiaokuang Ma, Luisa M. Rojas Valencia, P. David Adelson, Jonathan Lifshitz, Rachel K. Rowe, Maha Saber
Publikováno v:
J Neurotrauma
Intimate partner violence (IPV) increases risk of traumatic brain injury (TBI). Physical assaults increase in frequency and intensity during pregnancy. The consequences of TBI during pregnancy (gravida TBI; gTBI) on offspring development is unknown,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574ba375ec150c9df9c457bfe5bf89b4
https://doi.org/10.1089/neu.2021.0048
https://doi.org/10.1089/neu.2021.0048
Autor:
Jin G Park, Samantha Carotenuto, Alexander J Summers, Jing Wei, Xiaokuang Ma, Ross Johnson, Nicole Teru Quintus, Shenfeng Qiu, Hee-Dae Kim, Deveroux Ferguson, Chenxi Xu, Tanessa Call
Publikováno v:
Molecular Psychiatry. 26:7316-7327
Depression is the leading cause of disability and produces enormous health and economic burdens. Current treatment approaches for depression are largely ineffective and leave more than 50% of patients symptomatic, mainly because of non-selective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38127a2b8a403447581c1fc0c823862
https://doi.org/10.1038/s41380-021-01217-8
https://doi.org/10.1038/s41380-021-01217-8