Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Xiaoke Pan"'
Autor:
Takayuki Jujo Sanada, Xue D. Manz, Petr Symersky, Xiaoke Pan, Keimei Yoshida, Jurjan Aman, Harm Jan Bogaard
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by elevated pulmonary arterial pressure and organized thrombi within pulmonary arteries. Riociguat is a soluble guanylate cyclase stimulator and is approved for patients
Externí odkaz:
https://doaj.org/article/4d2fb82d158f44a88621bc1b70bb2841
Autor:
Aida Llucià-Valldeperas, Rowan Smal, Fjodor T. Bekedam, Margaux Cé, Xiaoke Pan, Xue D. Manz, Paul J. M. Wijnker, Anton Vonk-Noordegraaf, Harm J. Bogaard, Marie-Jose Goumans, Frances S. de Man
Publikováno v:
Cells, Vol 10, Iss 12, p 3595 (2021)
Pulmonary arterial hypertension (PAH) patients eventually die of right heart failure (RHF). Currently, there is no suitable pre-clinical model to study PAH. Therefore, we aim to develop a right heart dysfunction (RHD) model using the 3-dimensional en
Externí odkaz:
https://doaj.org/article/6731cce43fa04dcfaec93b7219fc2b1a
Autor:
Maria Catalina Gomez-Puerto, Xiao-Qing Sun, Ingrid Schalij, Mar Orriols, Xiaoke Pan, Robert Szulcek, Marie-José Goumans, Harm-Jan Bogaard, Qian Zhou, Peter ten Dijke
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4130 (2020)
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by obstructed pulmonary vasculatures. Current therapies for PAH are limited and only alleviate symptoms. Reduced levels of BMPR2 are associated with PAH pathophysiology
Externí odkaz:
https://doaj.org/article/1469497c2c42475f926ee035f6a04c5d
Autor:
Anneloes Dummer, Nina Rol, Robert Szulcek, Kondababu Kurakula, Xiaoke Pan, Benjamin I. Visser, Harm Jan Bogaard, Marco C. DeRuiter, Marie-José Goumans, Beerend P. Hierck
Publikováno v:
Pulmonary Circulation, Vol 8 (2018)
Pulmonary arterial hypertension (PAH) is a syndrome characterized by progressive lung vascular remodelling, endothelial cell (EC) dysfunction, and excessive inflammation. The primary cilium is a sensory antenna that integrates signalling and fine tun
Externí odkaz:
https://doaj.org/article/9f0091ae4f4d429aa6c3945d02607208
Autor:
Xue D. Manz, Robert Szulcek, Xiaoke Pan, Petr Symersky, Chris Dickhoff, Jisca Majolée, Veerle Kremer, Elisabetta Michielon, Ekaterina S. Jordanova, Teodora Radonic, Irene V. Bijnsdorp, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Anton Vonk Noordegraaf, Frances S. de Man, Reinier A. Boon, Jan Voorberg, Peter L. Hordijk, Jurjan Aman, Harm Jan Bogaard
Publikováno v:
American journal of respiratory and critical care medicine, 205(7), 808-818. American Thoracic Society
Manz, X D, Szulcek, R, Pan, X, Symersky, P, Dickhoff, C, Majolee, J, Kremer, V, Michielon, E, Jordanova, E S, Radonic, T, Bijnsdorp, I V, Piersma, S R, Pham, T V, Jimenez, C R, Noordegraaf, A V, de Man, F S, Boon, R A, Voorberg, J, Hordijk, P L, Aman, J & Bogaard, H J 2022, ' Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 7, pp. 806-818 . https://doi.org/10.1164/rccm.202109-2075OC
American Journal of Respiratory and Critical Care Medicine, 205(7), 806-818. American Thoracic Society
Manz, X D, Szulcek, R, Pan, X, Symersky, P, Dickhoff, C, Majolee, J, Kremer, V, Michielon, E, Jordanova, E S, Radonic, T, Bijnsdorp, I V, Piersma, S R, Pham, T V, Jimenez, C R, Noordegraaf, A V, de Man, F S, Boon, R A, Voorberg, J, Hordijk, P L, Aman, J & Bogaard, H J 2022, ' Epigenetic Modification of the von Willebrand Factor Promoter Drives Platelet Aggregation on the Pulmonary Endothelium in Chronic Thromboembolic Pulmonary Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 7, pp. 806-818 . https://doi.org/10.1164/rccm.202109-2075OC
American Journal of Respiratory and Critical Care Medicine, 205(7), 806-818. American Thoracic Society
Rationale: von Willebrand factor (vWF) mediates platelet adhesion during thrombosis. While chronic thromboembolic pulmonary hypertension (CTEPH) is associated with increased plasma levels of vWF, the role of this protein in CTEPH has remained enigmat
Autor:
Denielli da Silva Goncalves Bos, Robert Szulcek, Frances S. de Man, Xiaoke Pan, Maria Catalina Gomez-Puerto, Willem J. van der Laarse, Ingrid Schalij, Anton Vonk Noordegraaf, Harm Jan Bogaard, Roy E. J. Schiepers, Eva L. Peters, Stine Andersen, Asger Andersen, Marie-José Goumans, Xiao-Qing Sun, Julie Birkmose Axelsen, Kondababu Kurakula
Publikováno v:
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E, Andersen, A, Goumans, M-J, Vonk Noordegraaf, A, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A Activity Promotes Progression of Pulmonary Arterial Hypertension ', American Journal of Respiratory Cell and Molecular Biology (Online), vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. American Thoracic Society
Sun, X-Q, Peters, E L, Schalij, I, Axelsen, J B, Andersen, S, Kurakula, K, Gomez-Puerto, M C, Szulcek, R, Pan, X, da Silva Goncalves Bos, D, Schiepers, R E J, Andersen, A, Goumans, M-J, Noordegraaf, A V, van der Laarse, W J, de Man, F S & Bogaard, H J 2021, ' Increased MAO-A activity promotes progression of pulmonary arterial hypertension ', American Journal of Respiratory Cell and Molecular Biology, vol. 64, no. 3, pp. 331-343 . https://doi.org/10.1165/rcmb.2020-0105OC, https://doi.org/10.1165/rcmb.2020-0105OC
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 64(3), 331-343. AMER THORACIC SOC
Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial membrane, are important sources of reactive oxygen species. Increased MAO-A activity in endothelial cells and cardiomyocytes contributes to vascular dysfunction and progre
Autor:
Ly Tu, Franziska Herrmann, Xiaoke Pan, Robert Szulcek, Frances S. de Man, Anton Vonk-Noordegraaf, Geerten P. van Nieuw Amerongen, Harm Jan Bogaard, Chris Dickhoff, Kondababu Kurakula, Christophe Guignabert, Michiel Alexander de Raaf, Denielli da Silva Goncalves Bos, Nina Rol, Vincent P Kuiper, Kirsten Lodder, Xiaoqing Q Sun, Pieter Koolwijk, Chris Happé, Ingrid Schalij, Raphaël Thuillet, Marie-José Goumans, Lutz Wollin
Publikováno v:
Cardiovascular Research, 115(2), 432-439. Oxford University Press
Rol, N, de Raaf, M A, Sun, X Q, Kuiper, V P, da Silva Gonçalves Bos, D, Happé, C, Kurakula, K, Dickhoff, C, Thuillet, R, Tu, L, Guignabert, C, Schalij, I, Lodder, K, Pan, X, Herrmann, F E, van Nieuw Amerongen, G P, Koolwijk, P, Vonk-Noordegraaf, A, de Man, F S, Wollin, L, Goumans, M-J, Szulcek, R & Bogaard, H J 2019, ' Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension ', Cardiovascular Research, vol. 115, no. 2, pp. 432-439 . https://doi.org/10.1093/cvr/cvy186, https://doi.org/10.1093/cvr/cvy186
Cardiovascular Research, 115(2), 432-439. OXFORD UNIV PRESS
Rol, N, de Raaf, M A, Sun, X Q, Kuiper, V P, da Silva Gonçalves Bos, D, Happé, C, Kurakula, K, Dickhoff, C, Thuillet, R, Tu, L, Guignabert, C, Schalij, I, Lodder, K, Pan, X, Herrmann, F E, van Nieuw Amerongen, G P, Koolwijk, P, Vonk-Noordegraaf, A, de Man, F S, Wollin, L, Goumans, M-J, Szulcek, R & Bogaard, H J 2019, ' Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension ', Cardiovascular Research, vol. 115, no. 2, pp. 432-439 . https://doi.org/10.1093/cvr/cvy186, https://doi.org/10.1093/cvr/cvy186
Cardiovascular Research, 115(2), 432-439. OXFORD UNIV PRESS
Aims: Pulmonary arterial hypertension (PAH) is associated with increased levels of circulating growth factors and corresponding receptors such as platelet derived growth factor, fibroblast growth factor and vascular endothelial growth factor. Ninteda
Akademický článek
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Autor:
Lai Ming Yung, Hailiang Mei, Kondababu Kurakula, Roula Tsonaka, Xiaoke Pan, Xue D Manz, Wim Timens, Robert Szulcek, Marie-José Goumans, Paul B. Yu, Harm-Jan Bogaard, Szymon M. Kielbasa, Chris Dickhoff, Nina Rol, Gonzalo Sanchez-Duffhues
Publikováno v:
Angiogenesis, 23(4), 699-714. Springer Netherlands
Angiogenesis, 23(4), 699-714. SPRINGER
Angiogenesis, 23, 699-714. SPRINGER
Angiogenesis
Szulcek, R, Sanchez-Duffhues, G, Rol, N, Pan, X, Tsonaka, R, Dickhoff, C, Yung, L M, Manz, X D, Kurakula, K, Kiełbasa, S M, Mei, H, Timens, W, Yu, P B, Bogaard, H-J & Goumans, M-J 2020, ' Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells ', Angiogenesis, vol. 23, no. 4, pp. 699-714 . https://doi.org/10.1007/s10456-020-09741-x
Angiogenesis, 23(4), 699-714. SPRINGER
Angiogenesis, 23, 699-714. SPRINGER
Angiogenesis
Szulcek, R, Sanchez-Duffhues, G, Rol, N, Pan, X, Tsonaka, R, Dickhoff, C, Yung, L M, Manz, X D, Kurakula, K, Kiełbasa, S M, Mei, H, Timens, W, Yu, P B, Bogaard, H-J & Goumans, M-J 2020, ' Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells ', Angiogenesis, vol. 23, no. 4, pp. 699-714 . https://doi.org/10.1007/s10456-020-09741-x
Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82464bd21e980c08888b188a500194e
https://research.vumc.nl/en/publications/e9c39b1e-16fa-46c2-bb7e-bfcd271a8564
https://research.vumc.nl/en/publications/e9c39b1e-16fa-46c2-bb7e-bfcd271a8564
Autor:
Peter L. Hordijk, Jisca Majolée, Robert Szulcek, Jan Voorberg, Xue D Manz, Petr Symersky, Harm Jan Bogaard, Jurjan Aman, Xiaoke Pan
Publikováno v:
Pulmonary hypertension.