Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Xiaokan Zhang"'
Autor:
Bryan Z Wang, Lori J Luo, Xiaokan Zhang, Margaretha Morsink, Rajesh Soni, Roberta I Lock, Youngbin Kim, Trevor Nash, Joshua Gorham, Barry Fine, Jonathan G Seidman, Christine E Seidman, Gordana Vunjak-Novakovic
Publikováno v:
Circulation Research. 131
Introduction: Mutations in BAG3 result in dilated cardiomyopathy with cardiac fibrosis. Currently, the role of BAG3 in non-myocyte cell types is not known. We tested the hypothesis that BAG3 controls cardiac fibroblast (CF) function and that the loss
Autor:
Bryan Z. Wang, Trevor R. Nash, Xiaokan Zhang, Jenny Rao, Laura Abriola, Youngbin Kim, Sergey Zakharov, Michael Kim, Lori J. Luo, Margaretha Morsink, Bohao Liu, Roberta I. Lock, Sharon Fleischer, Manuel A. Tamargo, Michael Bohnen, Carrie L. Welch, Wendy K. Chung, Steven O. Marx, Yulia V. Surovtseva, Gordana Vunjak-Novakovic, Barry M. Fine
Publikováno v:
Cell Reports Medicine. 4:100976
Autor:
Xiaokan Zhang, Bryan Z. Wang, Michael Kim, Trevor R. Nash, Bohao Liu, Jenny Rao, Roberta Lock, Manuel Tamargo, Rajesh Kumar Soni, John Belov, Eric Li, Gordana Vunjak-Novakovic, Barry Fine
Publikováno v:
Cell Reports. 40:111203
SummaryIn the heart, Protein Kinase A (PKA) is critical for activating calcium handling and sarcomeric proteins in response to beta adrenergic stimulation leading to increased myocardial contractility and performance. The catalytic activity of PKA is
Autor:
P. Christian Schulze, Ruiping Ji, E. Douglas Lewandowski, Matt Fasano, Andrew N. Carley, Joseph R. Goldenberg, Xiaokan Zhang
Publikováno v:
Circulation
Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating th
Publikováno v:
Sci Transl Med
Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targe
Autor:
Estibaliz Castillero, Hirokazu Akashi, Ira Schlosberg, Alexandra Sperry, H. Lee Sweeney, Shunichi Homma, Karina Guaman, Isaac George, P. Christian Schulze, Adam Recht, Ziad A. Ali, Ruiping Ji, Catherine Wang, Paolo C. Colombo, Xianghai Liao, Xiaokan Zhang, Marc Najjar, Giovanni Ferrari, Lea Maria Brandstetter, Marcia Gailes
Publikováno v:
Am J Physiol Heart Circ Physiol
Myostatin (MSTN) is a transforming growth factor (TGF)-β superfamily member that acts as a negative regulator of muscle growth and may play a role in cardiac remodeling. We hypothesized that inhibition of activin type II receptors (ACTRII) to reduce
Autor:
Xiaokan Zhang, Ruiping Ji, Tiffany Thomas, Donna M. Mancini, Amit Saha, Hiroo Takayama, Xianghai Liao, Estibaliz Castillero, Yoshifumi Naka, Danielle Brunjes, Isaac George, P. Christian Schulze, Peter J. Kennel
Publikováno v:
Circulation. Heart failure. 12(12)
Autor:
H. Lee Sweeney, Sanatkumar Patel, Diana Leung, Sheetal Hegde, Eric J. Stöhr, Ziad A. Ali, Xiaokan Zhang, Shunichi Homma, Koji Takeda, Joo-Eun S Park, Estibaliz Castillero, Veli K. Topkara, Nicholas P. Tatonetti, Yoshifumi Naka, Paolo C. Colombo, Hirokazu Akashi, Nathaniel Kheysin, Isaac George, Ruiping Ji, Nicholas Giangreco, P. Christian Schulze, Catherine Wang, Carlos Cuenca, Samantha Stein
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Clinical and experimental studies have suggested that the duration of left ventricular assist device (LVAD) support may affect remodeling of the failing heart. We aimed to 1) characterize the changes in Ca2+/calmodulin-dependent protein kinase type-I
Autor:
Shu Xiao, Emral Devany, Kenneth Ng, Rachele Dolce Rameau, Anjana Saxena, Xiaokan Zhang, Frida E. Kleiman, Zaineb Nadeem, Elif Caglar
Publikováno v:
RNA biology. 15(2)
Nucleolin (NCL) is an abundant stress-responsive, RNA-binding phosphoprotein that controls gene expression by regulating either mRNA stability and/or translation. NCL binds to the AU-rich element (ARE) in the 3'UTR of target mRNAs, mediates miRNA fun
Autor:
Mirjana Persaud, Emral Devany, Xiaokan Zhang, Michael R. Murphy, Frida E. Kleiman, Galina Glazman
Publikováno v:
Nucleic Acids Research
mRNA deadenylation is under the control of cis-acting regulatory elements, which include AU-rich elements (AREs) and microRNA (miRNA) targeting sites, within the 3′ untranslated region (3′ UTRs) of eukaryotic mRNAs. Deadenylases promote miRNA-ind