Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xiaojing Sui"'
Autor:
Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 919-927 (2017)
Summary: Competing models exist in the literature for the relationship between mutant Huntingtin exon 1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering the proteotoxicity of soluble Httex1. In the other, inc
Externí odkaz:
https://doaj.org/article/a88e3936e1a84e4ebc9bd6f66ea0df8a
Autor:
Xiaojing Sui, Miguel A. Prado, Joao A. Paulo, Steven P. Gygi, Daniel Finley, Richard I. Morimoto
The conformational stability of the proteome has tremendous implications for the health of the cell and its capacity to determine longevity or susceptibility to age-associated degenerative diseases. For humans, this question of proteome conformationa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6520dbb4414487f8f8d9224072fb65
https://doi.org/10.1101/2022.09.28.509812
https://doi.org/10.1101/2022.09.28.509812
Publikováno v:
Journal of proteome research. 21(5)
Eukaryotic cells respond to heat shock through several regulatory processes including upregulation of stress responsive chaperones and reversible shutdown of cellular activities through formation of protein assemblies. However, the underlying regulat
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2428
Proteome solubility contains latent information on the nature of protein interaction networks in cells and changes in solubility can provide information on rewiring of networks. Here, we report a simple one-step ultracentrifugation method to separate
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619742
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7496a7683ef04e249b3a98d158431b54
https://doi.org/10.1007/978-1-0716-1975-9_16
https://doi.org/10.1007/978-1-0716-1975-9_16
Publikováno v:
Seminars in Cell & Developmental Biology. 99:40-54
Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control machinery comprising over 800 genes. When proteostasis becomes imbalanced, proteins can abnormally aggregate or become mis
Autor:
Michele Vendruscolo, Xiaojing Sui, Douglas E. V. Pires, Angelique R. Ormsby, Gavin E. Reid, Danny M. Hatters, David B. Ascher, Giulia Vecchi, Dezerae Cox, Shuai Nie
Publikováno v:
Proc Natl Acad Sci U S A
The accumulation of protein deposits in neurodegenerative diseases has been hypothesized to depend on a metastable subproteome vulnerable to aggregation. To investigate this phenomenon and the mechanisms that regulate it, we measured the solubility o
Autor:
Till Böcking, Jonathan C. Niclis, Michael J. Baker, Yasmin M. Ramdzan, Xiaojing Sui, Diana Stojanovski, Ching-Seng Ang, Nagaraj S. Moily, Steven Finkbeiner, Angelique R. Ormsby, Estella A. Newcombe, David B. Ascher, Clare L. Parish, Jacqueline A. Wilce, Marie N. Bongiovanni, Danny M. Hatters, Mark J. Tobin, Anthony W. Purcell, Saboora Waris, Mikhail M. Trubetskov, Grant Dewson, Sally L. Gras, Jason Miller, Gavin E. Reid
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 919-927 (2017)
Summary: Competing models exist in the literature for the relationship between mutant Huntingtin exon 1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering the proteotoxicity of soluble Httex1. In the other, inc
Publikováno v:
IUBMB Life. 69:49-54
Protein aggregation is a hallmark of the major neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's and motor neuron and is a symptom of a breakdown in the management of proteome foldedness. Indeed, it is remarkable that under
Autor:
Shuai Nie, Michele Vendruscolo, David B. Ascher, Giulia Vecchi, Danny M. Hatters, Gavin E. Reid, Douglas E. V. Pires, Xiaojing Sui
SUMMARY The accumulation of wide range of different protein deposits in neurodegenerative diseases has been associated with the presence of a metastable subproteome vulnerable to aggregation. To investigate this subproteome and the mechanisms that re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c303165ac26c849153ad6277c585b64
https://doi.org/10.1101/692103
https://doi.org/10.1101/692103