Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Xiaohui Si"'
Autor:
Xiujian Wang, Xiao Tao, Pengjie Chen, Penglei Jiang, Wenxiao Li, Hefeng Chang, Cong Wei, Xinyi Lai, Hao Zhang, Yihan Pan, Lijuan Ding, Zuyu Liang, Jiazhen Cui, Mi Shao, Xinyi Teng, Tianning Gu, Jieping Wei, Delin Kong, Xiaohui Si, Yingli Han, Huarui Fu, Yu Lin, Jian Yu, Xia Li, Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-19 (2024)
Abstract Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T (CAR-T) cells. MEK1/2 inhibitors (MEKIs), widely used in cancer tre
Externí odkaz:
https://doaj.org/article/0816439743404e7798ff840fc4af4ccb
Autor:
Meng Zhu, Yingli Han, Tianning Gu, Rui Wang, Xiaohui Si, Delin Kong, Peng Zhao, Xiujian Wang, Jinxin Li, Xingyuan Zhai, Zebin Yu, Huan Lu, Jingyi Li, He Huang, Pengxu Qian
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114065- (2024)
Summary: Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion closely ties with intrinsic transcriptional regulation
Externí odkaz:
https://doaj.org/article/4002cebb8fe3455dbdb5f59b03c63f52
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Due to their unique location, airway tumors have a significant impact on patient quality of life and survival. Current research has focused extensively on malignant airway tumors; however, benign airway tumors, especially rare ones, are less understo
Externí odkaz:
https://doaj.org/article/312093c4ff324b2e90fb98e76624ed47
Autor:
Hanbing Liu, Junxia Liu, Xiaohui Si, Shuhong Zhang, Lili Zhang, Xuejiao Tong, Xihong Yu, Xinmei Jiang, Yao Cheng
Publikováno v:
Plants, Vol 13, Iss 16, p 2302 (2024)
The powdery mildew caused by Eeysiphe heraclei is a serious concern in Heracleum moellendorffii Hance. Therefore, exploring the mechanisms underlying sugar efflux from host cells to the fungus during the plant–fungus interaction showed great signif
Externí odkaz:
https://doaj.org/article/53749dcbbb5446138afb87e7839bd9a7
Publikováno v:
Biology, Vol 13, Iss 6, p 374 (2024)
The endothelial barrier plays a critical role in immune defense against bacterial infection. Efficient interactions between neutrophils and endothelial cells facilitate the activation of both cell types. However, neutrophil activation can have dual e
Externí odkaz:
https://doaj.org/article/dc29120bdd414854961763ce13b34ad7
Autor:
Xun Wang, Xingyu Li, Fuxing Yang, Ling Zhao, Cheng Meng, Yuhao Gao, Hongrui Guo, Xiaohui Si, Haifeng Liu, Anan Jiang, Xuewei Li
Publikováno v:
Poultry Science, Vol 102, Iss 11, Pp 103088- (2023)
ABSTRACT: Proteins are considered major effectors of sperm function. However, the proteins expressed in pigeon sperm have not been explored. Here, we collected semen from meat and racing pigeons using the electroejaculation method and identified prot
Externí odkaz:
https://doaj.org/article/394cc40d5f0648a4ae8912ac26fa2059
Autor:
Lumin Liu, Bingli Chen, Xiaohui Si, Wenguang Hou, Qian Fan, Xu Li, Juanjuan Li, Shuren Ming, Ping Yin, Yuelai Chen
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundStress urinary incontinence (SUI) is a common condition that can severely affect women’s life quality. Electroacupuncture (EA) has been proved to be an optional treatment for SUI, but the tolerance of EA becomes a factor affecting efficie
Externí odkaz:
https://doaj.org/article/5b89db7bcdd946958ecb8ee6f922ffd5
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-20 (2022)
Abstract Short persistence and early exhaustion of T cells are major limits to the efficacy and broad application of immunotherapy. Exhausted T and chimeric antigen receptor (CAR)-T cells upregulate expression of genes associated with terminated T ce
Externí odkaz:
https://doaj.org/article/91f888ced59e41aca5c7504c205abe7b
Autor:
Mi Shao, Xinyi Teng, Xin Guo, Hao Zhang, Yue Huang, Jiazhen Cui, Xiaohui Si, Lijuan Ding, Xiujian Wang, Xia Li, Jimin Shi, Mingming Zhang, Delin Kong, Tianning Gu, Yongxian Hu, Pengxu Qian, He Huang
Publikováno v:
Advanced Science, Vol 9, Iss 9, Pp n/a-n/a (2022)
Abstract Chimeric antigen receptor (CAR) T cells are potent agents for recognizing and eliminating tumors, and have achieved remarkable success in the treatment of patients with refractory leukemia and lymphoma. However, dysfunction of T cells, inclu
Externí odkaz:
https://doaj.org/article/bcc88f7d17d948169c9f9d3d57499b41
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system, and leukemia stem cells are responsible for AML chemoresistance and relapse. KG-1a cell is considered a leukemia stem cell-enriched cell line, which is resistant to chemot
Externí odkaz:
https://doaj.org/article/256b4e4e9bef4f198b871804f9a3e502