Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Xiaohua Yan"'
Autor:
Zuxi Feng, Yanghuan Ou, Xueqiang Deng, Minghao Deng, Xiaohua Yan, Leifeng Chen, Fan Zhou, Liang Hao
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background Deubiquitinating enzymes (DUBs) are pivotal in maintaining cell homeostasis by regulating substrate protein ubiquitination in both healthy and cancer cells. Ubiquitin-specific protease 10 (USP10) belongs to the DUB family. In this
Externí odkaz:
https://doaj.org/article/a271d14a4a3747e086100fa1ec8bb918
Autor:
Junyao Cheng, Linlin Xu, Yanlu Xuan, Feifei Zhou, Aidi Huang, Shaopeng Zeng, Hailong Wang, Yiting Wang, Yuan Zhan, Xiaohua Yan, Shiwen Luo, Yuan Liu, Minzhang Cheng
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The linear ubiquitin chain assembly complex (LUBAC) mediates the linear ubiquitination of various proteins and is involved in NF-κB signaling and immune regulation. However, the function and mechanism of linear ubiquitination in regulating
Externí odkaz:
https://doaj.org/article/a8327bc321ad4e188682c4d16981cd67
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36469- (2024)
Dysregulation of lncRNAs is a critical factor in the migration and invasion of tumors. Here our study reveals that lncRNA HIF1A-AS2 is highly expressed in breast cancer tissues and various TNBC cell lines. Moreover, we present compelling evidence sup
Externí odkaz:
https://doaj.org/article/5a18886ff0f64808b6e4084121b0b869
Autor:
Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected to host-mediated post-translational modifications. Here, we demon
Externí odkaz:
https://doaj.org/article/e3e9e519f6b84b0e8f7d6e0867082a16
Autor:
Cheng Zhang, Zhihua Li, Kaiheng Hu, Yifei Ren, Haoran Zhang, Yuankang Zhao, Wenjing Wei, Shuo Tu, Xiaohua Yan
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Due to the therapeutic resistance of endocrine therapy and the limited efficacy of immune checkpoint inhibitors in estrogen receptor (ER)-positive breast cancer (BRCA), there is an urgent need to develop novel prognostic markers and understand the re
Externí odkaz:
https://doaj.org/article/e74a94d3f023474b8ce8449011171fc2
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/46a599d064c44f8781b9bf8c8c87e245
Autor:
Zhenghong Lin, Xiaohua Yan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/3edf6f54bdf846e69a49dbbcbee1645b
Autor:
Charles P. Couturier, Shamini Ayyadhury, Phuong U. Le, Javad Nadaf, Jean Monlong, Gabriele Riva, Redouane Allache, Salma Baig, Xiaohua Yan, Mathieu Bourgey, Changseok Lee, Yu Chang David Wang, V. Wee Yong, Marie-Christine Guiot, Hamed Najafabadi, Bratislav Misic, Jack Antel, Guillaume Bourque, Jiannis Ragoussis, Kevin Petrecca
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation
Externí odkaz:
https://doaj.org/article/b6efd45faa5f47efaab210dc9f398a89
Autor:
Ling Dong, Le Yu, Hui Li, Lei Shi, Zhong Luo, Huakan Zhao, Zhaojian Liu, Guobing Yin, Xiaohua Yan, Zhenghong Lin
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101351- (2020)
Summary: Ubiquitin specific protease 39 (USP39), an ortholog of Sad1p in yeast, is essential for spliceosome assembly during pre-mRNA splicing in human. Although it is known that USP39 is upregulated and plays an oncogenic role in hepatocellular carc
Externí odkaz:
https://doaj.org/article/2f361c8bfbac4c7d867ee35d43852352
Autor:
Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in
Externí odkaz:
https://doaj.org/article/c9f4c20d0b034062b275d5bddb7b2a17