Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Xiaohua Xue"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Autor:
Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, Samuel DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Thomas Hoffmann, Anne M. Fourie, Robin L. Thurmond
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17 axis is implica
Externí odkaz:
https://doaj.org/article/b41726b0e6ed4617b45bd45046be2ee9
Autor:
Xiaohua Xue, Aimee De Leon-Tabaldo, Rosa Luna-Roman, Glenda Castro, Michael Albers, Freddy Schoetens, Samuel DePrimo, Damayanthi Devineni, Thomas Wilde, Steve Goldberg, Olaf Kinzel, Thomas Hoffmann, Anne M. Fourie, Robin L. Thurmond
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/8350d4860faf488fa4942f7353c6f062
Autor:
Wu-Chun Cao, Lili Deng, Xianyu Lin, Ximing Wang, Yuyan Ma, Qiuyun Deng, Xiaohua Xue, Ge Zhong, Li Jin
Publikováno v:
Emerging Infectious Diseases, Vol 24, Iss 4, Pp 774-778 (2018)
During May–August 2016, mumps virus genotype K was detected in 12 Vietnam citizens who entered China at the Shuikou border crossing and 1 girl from China. We provide evidence that mumps genotype K is circulating in Vietnam and was imported to China
Externí odkaz:
https://doaj.org/article/ffd7f3e6c1dd4d95853445b080bdc9d2
Autor:
Glenda Castro, Xuejun Liu, Karen Ngo, Aimee De Leon-Tabaldo, Shanrong Zhao, Rosa Luna-Roman, Jingxue Yu, Tinghua Cao, Robert Kuhn, Patrick Wilkinson, Krystal Herman, Marina I Nelen, Jonathan Blevitt, Xiaohua Xue, Anne Fourie, Wai-Ping Fung-Leung
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181868 (2017)
RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characteriz
Externí odkaz:
https://doaj.org/article/6c82476fae6a4a61ba1a8cc89e0748b9
Publikováno v:
Zhejiang Da Xue Xue Bao Yi Xue Ban
OBJECTIVE: To early differentiate between coronavirus disease 2019 (COVID-19) and adult mycoplasma pneumonia with chest CT scan. METHODS: Twenty-six patients with COVID-19 and 21 patients with adult mycoplasma pneumonia confirmed with RT-PCR test wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5e7adf646c0a34bf77e8a7394ef0162
https://pubmed.ncbi.nlm.nih.gov/32985160
https://pubmed.ncbi.nlm.nih.gov/32985160
Autor:
Anne M. Fourie, Steven D. Goldberg, Maxwell D. Cummings, Christoph Steeneck, Thomas Hoffmann, Xiaohua Xue, Michael Albers, Christian Gege, John Spurlino, Kristi A. Leonard, Marina I. Nelen, Cindy Milligan, James P. Edwards, Gerald Kleymann, Olaf Kinzel, Thomas Schlüter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1446-1455
The nuclear receptor retinoic acid receptor-related orphan receptor gamma t (RORγt) is a transcription factor that drives Th17 cell differentiation and IL-17 production in both innate and adaptive immune cells. The IL-23/IL-17 pathway is implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26717ddfdaa64c66ae493163cdbd20a
https://doi.org/10.1016/j.bmcl.2018.03.093
https://doi.org/10.1016/j.bmcl.2018.03.093
Autor:
Anne M. Fourie, Glenda Castro, John Spurlino, Rachel Nishimura, Xiaohua Xue, Maxwell D. Cummings, Maud Urbanski, Kevin D. Kreutter, Umar Maharoof, Aihua Wang, David A. Kummer, J. Kent Barbay, James P. Edwards, Kristi A. Leonard, Ronald L. Wolin, Hariharan Venkatesan, Marta Cristina Abad, Celine Schalk-Hihi, Craig R. Woods, Cynthia M. Milligan, Joan Pierce, Virginia M. Tanis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5277-5283
We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2690b51b17762744f29691e68c6d5
https://doi.org/10.1016/j.bmcl.2017.10.027
https://doi.org/10.1016/j.bmcl.2017.10.027
Autor:
Maxwell D. Cummings, Thomas Schlueter, David A. Kummer, J. Kent Barbay, Krystal Herman, Craig R. Woods, John Spurlino, Kristi A. Leonard, Cynthia M. Milligan, Hariharan Venkatesan, Rachel Nishimura, Michael Albers, Ronald L. Wolin, James P. Edwards, Marina I. Nelen, Xiaohua Xue, Anne M. Fourie, Virginia M. Tanis, Brian Scott
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(12)
We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but are high molecular weight and they exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9ffb81bdf736a1e085c1c3d7cca302
https://pubmed.ncbi.nlm.nih.gov/31010722
https://pubmed.ncbi.nlm.nih.gov/31010722
Autor:
Xiaohua Xue, Christian Gege, Christoph Steeneck, Andreas Schulz, Kristi A. Leonard, Gerald Kleymann, Michael Albers, Steven D. Goldberg, Olaf Kinzel, Thomas J. Hoffmann, Thomas Schlüter, Maxwell D. Cummings, James P. Edwards, Anne M. Fourie, Brian Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127174
Starting from previously identified thiazole-2-carboxamides exemplified by compound 1/6, two new series of RORγt inverse agonists with significantly improved aqueous solubility, ADME parameters and oral PK properties were discovered. These scaffolds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71298a25d93e2b8353b18c097db7f1f9
https://doi.org/10.1016/j.bmcl.2020.127174
https://doi.org/10.1016/j.bmcl.2020.127174