Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Xiaohao Wu"'
Autor:
Donghao Gan, Chu Tao, Xiaowan Jin, Xiaohao Wu, Qinnan Yan, Yiming Zhong, Qingyun Jia, Lisheng Wu, Shaochuan Huo, Lei Qin, Guozhi Xiao
Publikováno v:
Journal of Advanced Research, Vol 62, Iss , Pp 105-117 (2024)
Introduction: Osteoarthritis (OA) is a devastating whole-joint disease affecting a large population worldwide with no cure; its mechanism remains poorly defined. Abnormal mechanical stress is the main pathological factor of OA. Objectives: To investi
Externí odkaz:
https://doaj.org/article/1d95a3e907bf4573b6f90f2aa37d980d
Autor:
Hongzhen Chen, Xuekun Fu, Xiaohao Wu, Junyi Zhao, Fang Qiu, Zhenghong Wang, Zhuqian Wang, Xinxin Chen, Duoli Xie, Jie Huang, Junyu Fan, Xu Yang, Yi Song, Jie Li, Dongyi He, Guozhi Xiao, Aiping Lu, Chao Liang
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold an opinion that gut microbiota is environmentally acquired and associated with RA susceptibility. However, accumulating evidence demonstrates that genetics also shape the
Externí odkaz:
https://doaj.org/article/ad9babdfb69d4515886707832b3cd54e
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-21 (2024)
Abstract Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of approximately 60% of the transc
Externí odkaz:
https://doaj.org/article/fcfc7ace76954227b4fa48bdd5ae1686
Autor:
Qing Yao, Weiyuan Gong, Xiaohao Wu, Donghao Gan, Chu Tao, Sixiong Lin, Minghao Qu, Zhongtian Ouyang, Mingjue Chen, Xinjia Hu, Guozhi Xiao
Publikováno v:
Journal of Orthopaedic Translation, Vol 41, Iss , Pp 12-19 (2023)
Background: Genetically modified mice are the most useful tools for investigating the gene functions in articular cartilage biology and the pathogenesis of osteoarthritis. The AggrecanCreERT2 mice are one of the most reported mouse lines used for thi
Externí odkaz:
https://doaj.org/article/7e79dd0e104b4a3893569885588c36c3
Autor:
Qing Yao, Xiaohao Wu, Chu Tao, Weiyuan Gong, Mingjue Chen, Minghao Qu, Yiming Zhong, Tailin He, Sheng Chen, Guozhi Xiao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-31 (2023)
Abstract Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide. OA was believed to be caused by the wearing and tearing of articular cartilage, but it is now more
Externí odkaz:
https://doaj.org/article/9ca642deaee14502b9c9e7fdf6f5ca77
Autor:
Yumei Lai, Wei Zheng, Minghao Qu, Christopher C. Xiao, Sheng Chen, Qing Yao, Weiyuan Gong, Chu Tao, Qinnan Yan, Peijun Zhang, Xiaohao Wu, Guozhi Xiao
Publikováno v:
International Journal of Oral Science, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract The progressive destruction of condylar cartilage is a hallmark of the temporomandibular joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood. Here, we show that Kindlin-2, a key focal adhesion protein, is stron
Externí odkaz:
https://doaj.org/article/e511152728c54ceb868b6aafe19d408f
Autor:
Sheng Chen, Xiaohao Wu, Yumei Lai, Di Chen, Xiaochun Bai, Sheng Liu, Yongchao Wu, Mingjue Chen, Yuxiao Lai, Huiling Cao, Zengwu Shao, Guozhi Xiao
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major social and economic burdens; however, its underlying molecular mechanisms remain poorly defined. Here we show that the focal adhesion protein Kindlin
Externí odkaz:
https://doaj.org/article/47808ea8d2424e2887018d47f912536f
Autor:
Sheng Chen, Mingjue Chen, Xiaohao Wu, Sixiong Lin, Chu Tao, Huiling Cao, Zengwu Shao, Guozhi Xiao
Publikováno v:
Journal of Orthopaedic Translation, Vol 32, Iss , Pp 49-58 (2022)
Background: To comprehensively analyze the global level and trends of prevalence, incidence and years lived with disability (YLDs) for low back pain (LBP) from 1990 to 2019 by age, sex and sociodemographic index (SDI). Methods: Publicly available mod
Externí odkaz:
https://doaj.org/article/0880f77338c440c79edcac78989d2530
Publikováno v:
Journal of Orthopaedic Translation, Vol 32, Iss , Pp 41-48 (2022)
Background: Our recent studies demonstrate that the focal adhesion protein Kindlin-2 exerts crucial functions in the mesenchymal stem cells, mature osteoblasts and osteocytes in control of early skeletal development and bone homeostasis in mice. Howe
Externí odkaz:
https://doaj.org/article/fbc0cfc1cd364b4abc6632951716dc92
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Pinch1 and Pinch2 are LIM domain-containing proteins with crucial functions in mediating focal adhesion formation. Our previous studies have demonstrated that Pinch1/2 expression is essential for cartilage and bone formation during skeletal developme
Externí odkaz:
https://doaj.org/article/d3a929213ac04e26a51e46cc73128dda