Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xiaohang Qiao"'
Autor:
Xiaohang Qiao, Sabina Y. van der Zanden, Xiaoyang Li, Minkang Tan, Yunxiang Zhang, Ji-Ying Song, Merle A. van Gelder, Feija L. Hamoen, Lennert Janssen, Charlotte L. Zuur, Baoxu Pang, Olaf van Tellingen, Junmin Li, Jacques Neefjes
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin and idarubicin, remains almost unmatched in oncology, despite a side effect profile including cumulative dose-dependen
Externí odkaz:
https://doaj.org/article/453ba61e41fd4ad09d69d3a4460e5eaa
Autor:
Joris L. Vos, Joris B. W. Elbers, Oscar Krijgsman, Joleen J. H. Traets, Xiaohang Qiao, Anne M. van der Leun, Yoni Lubeck, Iris M. Seignette, Laura A. Smit, Stefan M. Willems, Michiel W. M. van den Brekel, Richard Dirven, M. Baris Karakullukcu, Luc Karssemakers, W. Martin C. Klop, Peter J. F. M. Lohuis, Willem H. Schreuder, Ludi E. Smeele, Lilly-Ann van der Velden, I. Bing Tan, Suzanne Onderwater, Bas Jasperse, Wouter V. Vogel, Abrahim Al-Mamgani, Astrid Keijser, Vincent van der Noort, Annegien Broeks, Erik Hooijberg, Daniel S. Peeper, Ton N. Schumacher, Christian U. Blank, Jan Paul de Boer, John B. A. G. Haanen, Charlotte L. Zuur
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of ne
Externí odkaz:
https://doaj.org/article/761c20eac4bf4e0f8dc9495fdeadff61
Autor:
Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to pati
Externí odkaz:
https://doaj.org/article/d3b40c6ab0ea4445955311ad736bc6e4
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16428 (2011)
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, regulating inflammatory and immune responses. MIF binds to cell surface receptor CD74, resulting in both rapid and sustained ERK activation. It was reported that MIF-induced rapi
Externí odkaz:
https://doaj.org/article/f8ad9bd859a8444c8bd07c2fe016a02d
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
Figure S1: Keap1, SMARCB1, SMARCA4 and ARID1A regulate resistance to doxorubicin. Figure S2: Keap1 controls expression of NQO1 through Nrf2. Figure S3: C9orf82 regulates DNA double strand break repair. Figure S4: Expression of SWI/SNF complex subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a9d45689376baa1a6fc743164ecf9
https://doi.org/10.1158/0008-5472.22405203.v1
https://doi.org/10.1158/0008-5472.22405203.v1
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
The topoisomerase II poisons doxorubicin and etoposide constitute longstanding cornerstones of chemotherapy. Despite their extensive clinical use, many patients do not respond to these drugs. Using a genome-wide gene knockout approach, we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf0ba9912e353964a8eccbe0ae7d4ce
https://doi.org/10.1158/0008-5472.c.6506766.v1
https://doi.org/10.1158/0008-5472.c.6506766.v1
Autor:
Jacques Neefjes, Thijn R. Brummelkamp, Lodewyk Wessels, Lennert Janssen, Esther H. Lips, Marlous Hoogstraat, Vincent Blomen, Xiaohang Qiao, Sabina Y. van der Zanden, Baoxu Pang, Ruud H. Wijdeven
Table S1: Overview of all screening hits.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428406b8e60f1d5d6d56463cc45f7f0c
https://doi.org/10.1158/0008-5472.22405200.v1
https://doi.org/10.1158/0008-5472.22405200.v1
Autor:
Anne M. van der Leun, Joleen J. Traets, Joris L. Vos, Joris B. Elbers, Sanne Patiwael, Xiaohang Qiao, Mercedes Machuca-Ostos, Daniela S. Thommen, John B. Haanen, Ton N. Schumacher, Charlotte L. Zuur
Publikováno v:
Cancer Research. 83:2281-2281
Immune checkpoint blockade has shown clinical activity in a range of cancer types. To dissect the effect of neoadjuvant PD-1 and CTLA4 blockade on intratumoral T cells in head and neck squamous cell carcinoma, we analyzed immune infiltrates in tumor
Autor:
Yuri Diaz Fernandez, Domagoj Belić, Alexander P. Hill, Mathias Brust, Casper Kunstmann-Olsen, Stephen P. Danks, Xiaohang Qiao, Rasmita Raval, Ioritz Sorzabal-Bellido, Dan F. Bradley, Marcin P. Grzelczak
Publikováno v:
Nanoscale Advances
Selective unidirectional transport of barium ions between droplets in a water-in-chloroform emulsion is demonstrated. Gold nanoparticles (GNPs) modified with a thiolated crown ether act as barium ion complexing shuttles that carry the ions from one p
Autor:
Saman Naghibi, Sara Sangtarash, Varshini J. Kumar, Jian‐Zhong Wu, Martyna M. Judd, Xiaohang Qiao, Elena Gorenskaia, Simon J. Higgins, Nicholas Cox, Richard J. Nichols, Hatef Sadeghi, Paul J. Low, Andrea Vezzoli
Publikováno v:
Angewandte Chemie
The integration of radical (open-shell) species into single-molecule junctions at non-cryogenic temperatures is a key to unlocking the potential of molecular electronics in further applications. While many efforts have been devoted to this issue, in