Výsledky vyhledávání - "Xiaohan Zhai"

Akademický článek

The role of CBL family ubiquitin ligases in cancer progression and therapeutic strategies

Autor: Jiaqi Ren, Linlin Lv, Xufeng Tao, Xiaohan Zhai, Xuyang Chen, Hao Yu, Xinya Zhao, Xin Kong, Zhan Yu, Deshi Dong, Jing Liu

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

The CBL (Casitas B-lineage lymphoma) family, as a class of ubiquitin ligases, can regulate signal transduction and activate receptor tyrosine kinases through various tyrosine kinase-dependent pathways. There are three members of the family: c-CBL, CB

Externí odkaz: https://doaj.org/article/905d21deeee6449cbc3b756ea07786ef

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Akademický článek

High temperature requirement A1 in cancer: biomarker and therapeutic target

Autor: Mingming Chen, Shilei Yang, Yu Wu, Zirui Zhao, Xiaohan Zhai, Deshi Dong

Publikováno v: Cancer Cell International, Vol 21, Iss 1, Pp 1-9 (2021)

Abstract As the life expectancy of the population increases worldwide, cancer is becoming a substantial public health problem. Considering its recurrence and mortality rates, most cancer cases are difficult to cure. In recent decades, a large number

Externí odkaz: https://doaj.org/article/8980e09645174adf8a6c0b489f8947ac

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Akademický článek

Machine Learning Techniques Applied to the Study of Drug Transporters

Autor: Xiaorui Kong, Kexin Lin, Gaolei Wu, Xufeng Tao, Xiaohan Zhai, Linlin Lv, Deshi Dong, Yanna Zhu, Shilei Yang

Publikováno v: Molecules, Vol 28, Iss 16, p 5936 (2023)

With the advancement of computer technology, machine learning-based artificial intelligence technology has been increasingly integrated and applied in the fields of medicine, biology, and pharmacy, thereby facilitating their development. Transporters

Externí odkaz: https://doaj.org/article/3d6f9b621f3e47978587a4d5c0c64609

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Akademický článek

Research Methods and New Advances in Drug–Drug Interactions Mediated by Renal Transporters

Autor: Kexin Lin, Xiaorui Kong, Xufeng Tao, Xiaohan Zhai, Linlin Lv, Deshi Dong, Shilei Yang, Yanna Zhu

Publikováno v: Molecules, Vol 28, Iss 13, p 5252 (2023)

The kidney is critical in the human body’s excretion of drugs and their metabolites. Renal transporters participate in actively secreting substances from the proximal tubular cells and reabsorbing them in the distal renal tubules. They can affect t

Externí odkaz: https://doaj.org/article/398070aaa2ab4e789beee0054fc48513

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Akademický článek

Relationship between metabolic reprogramming and drug resistance in breast cancer

Autor: Linlin Lv, Shilei Yang, Yanna Zhu, Xiaohan Zhai, Shuai Li, Xufeng Tao, Deshi Dong

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Breast cancer is the leading cause of cancer death in women. At present, chemotherapy is the main method to treat breast cancer in addition to surgery and radiotherapy, but the process of chemotherapy is often accompanied by the development of drug r

Externí odkaz: https://doaj.org/article/8b92a174b28c4a2cbd2e53c6282ec904

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Akademický článek

Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets

Autor: Yanna Zhu, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong, Xufeng Tao

Publikováno v: Molecules, Vol 27, Iss 19, p 6572 (2022)

Currently, both acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be the leading public health problems with gradually increasing incidence rates around the world. Rhein is a monomeric component of anthraquinone isolated fr

Externí odkaz: https://doaj.org/article/8255a0b3eebe41c0a729fd67bf9f7f11

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Akademický článek

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

Autor: Musen Lin, Xiaohan Zhai, Guangzhi Wang, Xiaofeng Tian, Dongyan Gao, Lei Shi, Hang Wu, Qing Fan, Jinyong Peng, Kexin Liu, Jihong Yao

Publikováno v: Journal of Pharmacological Sciences, Vol 127, Iss 2, Pp 203-210 (2015)

Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia

Externí odkaz: https://doaj.org/article/f44372698b614610abc3e9731c25e5b8

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