Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Xiaoguang, Fang"'
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma
Autor:
Weiwei Tao, Chengwei Chu, Wenchao Zhou, Zhi Huang, Kui Zhai, Xiaoguang Fang, Qian Huang, Aili Zhang, Xiuxing Wang, Xingjiang Yu, Haidong Huang, Qiulian Wu, Andrew E. Sloan, Jennifer S. Yu, Xiaoxia Li, George R. Stark, Jeremy N. Rich, Shideng Bao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The tumour microenvironment plays an important role in promoting glioblastoma. Here, the authors show that glioma stem cells secrete WISP1, which promotes both the survival of the stem cells and tumour-associated macrophages.
Externí odkaz:
https://doaj.org/article/80ed06b6daa44b72a61177b8c8e47066
Autor:
Weiwei Tao, Aili Zhang, Kui Zhai, Zhi Huang, Haidong Huang, Wenchao Zhou, Qian Huang, Xiaoguang Fang, Briana C Prager, Xiuxing Wang, Qiulian Wu, Andrew E Sloan, Manmeet S Ahluwalia, Justin D Lathia, Jennifer S Yu, Jeremy N Rich, Shideng Bao
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 12, Pp n/a-n/a (2020)
Abstract Nuclear matrix‐associated proteins (NMPs) play critical roles in regulating chromatin organization and gene transcription by binding to the matrix attachment regions (MARs) of DNA. However, the functional significance of NMPs in glioblasto
Externí odkaz:
https://doaj.org/article/a5397199295d45629c5bcb2033be3620
Autor:
Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N Rich, Shideng Bao, Xiu-Wu Bian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results
Externí odkaz:
https://doaj.org/article/fc10d4b4ab8a4e3cb428bc0e73382649
Autor:
Jeremy N. Rich, Shideng Bao, Vaidehi Mahadev, Zhe Zhu, Xiaoguang Fang, Wenchao Zhou, Zhen Dong, Anne Song, Christopher G. Hubert, Tyler E. Miller, Qi Xie, Sisi Lai, Yu Shi, Ryan C. Gimple, Leo J.Y. Kim, Kailin Yang, Stephen C. Mack, Briana C. Prager, Qiulian Wu, Zhi Huang, Xiuxing Wang
Supplementary Figure 1. Induction of differentiation by BMP4 decreased expression of mevalonate synthesis enzymes (HMGCR, PMVK, MVK, MVD, IDI1 and FDPS). Supplementary Figure 2. Gene expression data from TCGA GBM patients revealed a high degree of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d85ae70ac580cd0715de5dd0a9749e
https://doi.org/10.1158/0008-5472.22415327
https://doi.org/10.1158/0008-5472.22415327
Autor:
Jeremy N. Rich, Shideng Bao, Vaidehi Mahadev, Zhe Zhu, Xiaoguang Fang, Wenchao Zhou, Zhen Dong, Anne Song, Christopher G. Hubert, Tyler E. Miller, Qi Xie, Sisi Lai, Yu Shi, Ryan C. Gimple, Leo J.Y. Kim, Kailin Yang, Stephen C. Mack, Briana C. Prager, Qiulian Wu, Zhi Huang, Xiuxing Wang
Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocitrate dehydrogenase (IDH) mutations, but metabolic alterations in glioblastomas with wild-type IDH are poorly understood. MYC promotes metabolic reprogramming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d28074287457937279e96705b14f945
https://doi.org/10.1158/0008-5472.c.6509234.v1
https://doi.org/10.1158/0008-5472.c.6509234.v1
Autor:
Aili Zhang, Weiwei Tao, George R. Stark, Qian Huang, Xiaoguang Fang, Zhi Huang, Shideng Bao, Kui Zhai, Thomas A. Hamilton, Xiaoxia Li
Publikováno v:
Nature Cancer. 2:1136-1151
Glioblastoma (GBM) contains abundant tumor-associated macrophages (TAMs). The majority of TAMs are tumor-promoting macrophages (pTAMs), while tumor-suppressive macrophages (sTAMs) are the minority. Thus, reprogramming pTAMs into sTAMs represents an a
Autor:
Jianghong Man, Jocelyn Shoemake, Wenchao Zhou, Xiaoguang Fang, Qiulian Wu, Anthony Rizzo, Richard Prayson, Shideng Bao, Jeremy N. Rich, Jennifer S. Yu
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1812-1826 (2014)
Summary: Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ
Externí odkaz:
https://doaj.org/article/2083a50321224e64bca9da501aa446ba
Autor:
Wenchao Zhou, Jeremy N. Rich, Kui Zhai, Shideng Bao, Weiwei Tao, Andrew E. Sloan, Jennifer S. Yu, Aili Zhang, Xiaoguang Fang, Zhi Huang
Publikováno v:
Neuro Oncol
Background The tumorigenic potential of glioma stem cells (GSCs) is associated with multiple reversible molecular alternations, but the role of posttranslational protein sumoylation in GSCs has not been elucidated. The development of GSC-targeting dr
Autor:
McEwen, William1 bill_mcewen@gallup.com, Xiaoguang Fang2 xiaoguang_fang@gallup.com.cn, Chuanping Zhang3 chuanping_zhang@gallup.com.cn, Burkholder, Richard4 richard_burkholder@gallup.com
Publikováno v:
Harvard Business Review. Mar2006, Vol. 84 Issue 3, p68-76. 9p. 1 Color Photograph, 2 Illustrations, 3 Charts, 1 Graph.
Autor:
Shideng Bao, Kui Zhai, Xiaoguang Fang, Jeremy N. Rich, Zhi Huang, Leo J.Y. Kim, Jennifer S. Yu, Alexandru Almasan, Xiaoxia Li, Weiwei Tao, Qiulian Wu, Qian Huang, George R. Stark
Publikováno v:
Science Translational Medicine. 13
Glioblastoma (GBM), a lethal primary brain tumor, contains glioma stem cells (GSCs) that promote malignant progression and therapeutic resistance. SOX2 is a core transcription factor that maintains the properties of stem cells, including GSCs, but me