Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Xiaodong Xi"'
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on the cell surface and play key roles in cell adhesion, migration, and growth. Several types of integrins are expressed on the platelets, including αv
Externí odkaz:
https://doaj.org/article/92ee379b93b24279b3fbca6e00314d92
Autor:
Yu Zhang, Xiaodong Xi, Hang Yu, Liuyan Yang, Jinzhong Lin, Wen Yang, Junling Liu, Xuemei Fan, Yingjie Xu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 657-671 (2022)
The use of messenger RNA (mRNA) enables the transient production of therapeutic proteins with stable and predictable translational kinetics and without the risk of insertional mutagenesis. Recent findings highlight the enormous potential of mRNA-base
Externí odkaz:
https://doaj.org/article/6c5a5fe8260e42fca06fb80874f023bb
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1721 (2023)
To clarify whether arsenic could exert inhibitory effects on tumor cells in pleural effusions of patients with non-small cell lung cancer (NSCLC), 36 NSCLC pleural effusion samples were collected from Changzheng Hospital and Ruijin Hospital, from 201
Externí odkaz:
https://doaj.org/article/d66ca2b75238470fbd2c01e83b6fa2cd
Autor:
Jianhua Mao, Kongkai Zhu, Zhangbiao Long, Huimin Zhang, Bing Xiao, Wenda Xi, Yun Wang, Jiansong Huang, Jingqiu Liu, Xiaofeng Shi, Hao Jiang, Tian Lu, Yi Wen, Naixia Zhang, Qian Meng, Hu Zhou, Zheng Ruan, Jin Wang, Cheng Luo, Xiaodong Xi
Publikováno v:
Advanced Science, Vol 9, Iss 7, Pp n/a-n/a (2022)
Abstract Conventional antiplatelet agents indiscriminately inhibit both thrombosis and hemostasis, and the increased bleeding risk thus hampers their use at more aggressive dosages to achieve adequate effect. Blocking integrin αIIbβ3 outside‐in s
Externí odkaz:
https://doaj.org/article/356631c653964b98a69aadbfbb52960e
Autor:
Jiansong Huang, Xia Li, Xiaofeng Shi, Mark Zhu, Jinghan Wang, Shujuan Huang, Xin Huang, Huafeng Wang, Ling Li, Huan Deng, Yulan Zhou, Jianhua Mao, Zhangbiao Long, Zhixin Ma, Wenle Ye, Jiajia Pan, Xiaodong Xi, Jie Jin
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a high level in platelets and their progenitors, where it
Externí odkaz:
https://doaj.org/article/6884810a3a974681921d9601f4ed0c9e
Autor:
Dawei Wang, Xiaohu Shao, Qiang Wang, Xiaohong Pan, Yujun Dai, Shuxian Yao, Tong Yin, Zhugang Wang, Jiang Zhu, Xiaodong Xi, Zhu Chen, Saijuan Chen, Guowei Zhang
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)
Abstract Background Treatment of hemophiliacs with inhibitors remains challenging, and new treatments are in urgent need. Coagulation factor X plays a critical role in the downstream of blood coagulation cascade, which could serve as a bypassing agen
Externí odkaz:
https://doaj.org/article/b83192355dc9490cb7cc705cb9daf766
Autor:
Dawei Wang, Guowei Zhang, Junjie Gu, Xiaohu Shao, Yuting Dai, Jianfeng Li, Xiaohong Pan, Shuxian Yao, Aining Xu, Ying Jin, Jinyan Huang, Qizhen Shi, Jiang Zhu, Xiaodong Xi, Zhu Chen, Saijuan Chen
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/9a598662462644f2bb0107eee188725d
Autor:
Xiaofeng Shi, Jichun Yang, Xiongying Cui, Jiansong Huang, Zhangbiao Long, Yulan Zhou, Ping Liu, Lanlan Tao, Zheng Ruan, Bing Xiao, Wei Zhang, Dongya Li, Kesheng Dai, Jianhua Mao, Xiaodong Xi
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166136 (2016)
Previous studies in Chinese hamster ovary cells showed that truncational mutations of β3 at sites of F754 and Y759 mimicking calpain cleavage regulate integrin signaling. The roles of the sequence from F754 to C-terminus and the conservative N756ITY
Externí odkaz:
https://doaj.org/article/f8d9ca919e114af68af7c6e25bb36592
Autor:
Jianhua, Mao, Yun, Wang, Wei, Zhang, Yan, Shen, Guowei, Zhang, Wenda, Xi, Qiang, Wang, Zheng, Ruan, Jin, Wang, Xiaodong, Xi
Publikováno v:
Frontiers of Medicine. 16:584-595
Conventional therapies for hemophilia A (HA) are prophylactic or on-demand intravenous FVIII infusions. However, they are expensive and inconvenient to perform. Thus, better strategies for HA treatment must be developed. In this study, a recombinant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2d72b8ec69ab60b53e82e93efe0ac6
https://doi.org/10.1007/s11684-021-0844-7
https://doi.org/10.1007/s11684-021-0844-7
Autor:
Zheng Ruan, Dawei Wang, Bing Xiao, Guowei Zhang, Chao Fang, Xiaofeng Shi, Jin Wang, Jian-Hua Mao, Li Li, Yun Wang, Jian-Qing Mi, Yichen Liu, Xiaodong Xi
Publikováno v:
Thrombosis and Haemostasis. 122:755-766
Platelet-targeted FVIII gene therapy can efficiently recover bleeding phenotype for hemophilia A (HA), yet characteristics of thrombus formation with this ectopic expression of factor VIII (FVIII) in platelets remain unclear. Here, we generated 2bF8t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39114826ece994897571989ee8a5ca6
https://doi.org/10.1055/s-0041-1735531
https://doi.org/10.1055/s-0041-1735531