Výsledky vyhledávání

End-to-End DSM Fusion Networks for Semantic Segmentation in High-Resolution Aerial Images

Autor: Hongfeng Yu, Wenhui Diao, Kun Fu, Zhiying Cao, Menglong Yan, Xiaode Lu, Xian Sun, Hao Sun

Publikováno v: IEEE Geoscience and Remote Sensing Letters. 16:1766-1770

Semantic segmentation in high-resolution aerial images is a fundamental research problem in remote sensing field for its wide range of applications. However, it is difficult to distinguish regions with similar spectral features using only multispectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb3b50a9b42d6aca78a3ca8cab39ac6
https://doi.org/10.1109/lgrs.2019.2907009

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A novel phosphotyrosine mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (cpp): exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain

Autor: Shelia Violette, Noriyuki Kawahata, Catherine Bartlett, Tomi K. Sawyer, Regine S. Bohacek, Wei Guan, William C. Shakespeare, Xiaode Lu, Michael G. Yang, Yihan Wang, Jeremy Smith, Taylor Merry, Raji Sundaramoorthi, Charles J. Eyermann, George P. Luke, Daniel Johnson, Marcos Hatada, David C. Dalgarno

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2319-2323

The novel phosphotyrosine (pTyr) mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60 c-Src (Src) tyrosine kinase. A 2.2 A X-ray crystal st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af601780cedf13e8fb805c0fb106afb3
https://doi.org/10.1016/s0960-894x(01)00446-2

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Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

Autor: Jane F. Amara, Lauren F. Stevenson, Marcos Hatada, Michael Z. Gilman, Dennis A. Holt, Susan A. Wood, Xiaode Lu, Nancy L. Courage, Franklin Cerasoli, Shannon R. Magari, Tim Clackson, Leonard W. Rozamus, Wu Yang, Carl T. Rollins

Publikováno v: Proceedings of the National Academy of Sciences. 95:10437-10442

FKBP ligand homodimers can be used to activate signaling events inside cells and animals that have been engineered to express fusions between appropriate signaling domains and FKBP. However, use of these dimerizers in vivo is potentially limited by l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925ffe9e0cd18161ac3804c8a4cf27de
https://doi.org/10.1073/pnas.95.18.10437

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Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 å resolution

Autor: P. A. J. Janssen, Christopher J. Michejda, S.H. Hughes, Y. Hsiou, Eddy Arnold, Arthur D. Clark, S Jessen, Jianping Ding, Kalyan Das, Rudi Pauwels, Xiaode Lu, Wanyi Zhang, Richard H. Smith, Chris Tantillo, Luc Koymans, Henri Moereels, Koenraad Jozef Lodewijk Marcel Andries, Alfredo Jacobo-Molina, M.Kroeger Koepke

Publikováno v: Structure. 3:365-379

Background: HIV-1 reverse transcriptase (RT) is a multifunctional enzyme that copies the RNA genome of HIV-1 into DNA. It is a heterodimer composed of a 66 kDa (p66) and a 51 kDa (p51) subunit. HIV-1 RT is a crucial target for structure-based drug de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2813ef76a71bfcae3ecae25e4bff338a
https://doi.org/10.1016/s0969-2126(01)00168-x

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Buried surface analysis of HIV-1 reverse transcriptase p66/p51 heterodimer and its interaction with dsDNA template/primer

Autor: Chris Tantillo, Alfredo Jacobo-Molina, Edward Arnold, Raymond G. Nanni, Jianping Ding, Xiaode Lu

Publikováno v: Journal of Molecular Recognition. 7:157-161

The p66/p51 human immunodeficiency virus type 1 reverse transcriptase is a heterodimer with identical N-terminal amino acid sequences. The enzyme contains two polymerization domains and one RNase H domain, which is located at the C-terminus of the p6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a6cd8677f1a3e45f7c61c2f1d9ebdf
https://doi.org/10.1002/jmr.300070212

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ChemInform Abstract: Structure-Based Design and Synthesis of a Novel Class of SRC SH2 Inhibitors

Autor: Regine S. Bohacek, Xiaode Lu, John L. Buchanan, George P. Luke, Ruth W. Yuan, Marcos Hatada, David C. Dalgarno, Surinder S. Narula, Dennis A. Holt

Publikováno v: ChemInform. 30

The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c19a65203a2112e2a1292cdb6d8f5fdc
https://doi.org/10.1002/chin.199945235

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Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

Autor: Andrea L. Ferris, Anqiang Zhang, Edward Arnold, Raymond G. Nanni, Alfredo Jacobo-Molina, Amnon Hizi, Patrick K. Clark, Roger L. Williams, Arthur D. Clark, Stephen H. Hughes, Jianping Ding, Xiaode Lu

Publikováno v: Europe PubMed Central

AIDS, caused by human immunodeficiency virus (HIV), is one of the world's most serious health problems, with current protocols being inadequate for either prevention or successful long-term treatment. In retroviruses such as HIV, the enzyme reverse t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810a16d0cff31e96680e9ece1061f512
https://doi.org/10.1038/357085a0

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