Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Xiaoda Niu"'
Autor:
Xiaoli Pan, Shuyuan Chen, Liangmin Xiong, Lin Li, Yong Men, Xiaoda Niu, Yuanqiang Wang, Jinguo Wang, Wei An, Chenghui Sun, Xiaoyu Li, Shuang Liu
Publikováno v:
ACS Applied Nano Materials. 4:6020-6029
Autor:
Liangmin Xiong, Shuang Liu, Yong Men, Lin Li, Xiaoda Niu, Kailiang Guo, Junzhe Xu, Wei An, Jinguo Wang, Yu Cong
Publikováno v:
SSRN Electronic Journal.
Autor:
Liangmin Xiong, Shuang Liu, Yong Men, Lin Li, Xiaoda Niu, Kailiang Guo, Junzhe Xu, Wei An, Jinguo Wang, Yu Cong
Publikováno v:
Journal of Environmental Chemical Engineering. 10:108407
Autor:
Xiaoda Niu, Shuang Liu, Yong Men, Lin Li, Liangmin Xiong, Kailiang Guo, Junzhe Xu, Kunfeng Zhao, Ya Li, Wei An, Jinguo Wang
Publikováno v:
Molecular Catalysis. 529:112521
Autor:
Shiying Chen, Wensheng Yu, Joseph A. Kozlowski, Daniel Lundell, Seong Heon Kim, Ling Tong, Shelby Umland, Xiaoda Niu, Vinay Girijavallabhan, Lei Chen, Aneta Kosinski, Guowei Zhou, Mengwei Hu, Neng-Yang Shih, Bandarpalle B. Shankar, De-Yi Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3704-3708
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors led to fused bi-heteroaryl hydantoin series that demonstrate sub-nanomolar potency (Ki) as well as excellent activity in human whole blood (hWBA). However, lead compound 2 pos
Autor:
Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3037-3042
We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK
Autor:
Christopher Sondey, Theirry Fischmann, Kristine Devito, Haiquin Tang, W. Michael Seganish, Rui Zhang, Jennifer Hanisak, Hon-Chung Tsui, Deen Tulshian, Daniel Lundell, Charles G. Garlisi, William T. McElroy, Xiaoda Niu, James Fossetta, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4250-4255
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4 inhibitors designed to expand chemical diversi
Autor:
Xiaoda Niu, W. Michael Seganish, R. Jason Herr, James P. Harding, Deen Tulshian, Larry Yet, Brian J. Lavey, Thierry O. Fischmann, Koraboina Chandra Prakash, Christopher Sondey, William J. Greenlee, Jinhai Yang, Venukrishnan Komanduri, William T. McElroy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1836-1841
Interleukin receptor-associated kinase 4 (IRAK4) is a critical element of the Toll-like/interleukin-1 receptor inflammation signaling pathway. A screening campaign identified a novel diaminopyrimidine hit that exhibits weak IRAK4 inhibitory activity
Autor:
Aleksandr Petrov, Wen Feng, Ann E. Weber, Effie Tozzo, Lisa LaFranco Scheuch, Shiyao Xu, Wei Zhu, Nancy A. Thornberry, Dinko Gonzalez Trotter, Rory J. Rohm, Franklin Liu, Ku Lu, Michelle Bunzel, David E. Kelley, Stacey Conarello, Jinqi Liu, Corin O. Miller, Xiaoda Niu, Huaibing He, Ronald E. Painter, Ying Li, Daniel M. Kemp, Ying Qian, Maria E. Trujillo, Mark D. Erion, Liyang Wang, Iyassu K. Sebhat, Gaochao Zhou, Michael Klimas, Marie A. Holahan, Marc M. Kurtz, George J. Eiermann, Guillermo Fernandez, Bindu Bennet, Juliann Ehrhart, Tesfaye Biftu, Aimie Ogawa, Sandra C. Souza, Cai Li, Srinivasa Prahalada, James A. Milligan, Hong-Ping Guan, Danqing Feng, Robert W. Myers, Douglas Wisniewski, Xiaodong Yang, Daniel Rubins, Hongwu Wang, Margaret van Heek
Publikováno v:
Science (New York, N.Y.). 357(6350)
Hitting a dozen enzymes with one drug The adenosine monophosphate-activated protein kinase (AMPK) controls cellular energy status. AMPK is activated when energy levels fall. This stimulates adenosine triphosphate (ATP)-generating pathways that promot
Autor:
Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3172-3176
TNF-α converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporatin