Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Xiaochun, Yu"'
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background RNA–DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination (CSR). However, the underlying phenomenon regulating the two contrasting functions of R-loop
Externí odkaz:
https://doaj.org/article/7b15e100421340b5a3a8e3d42ac8fe09
Autor:
Duo Wu, Huang Huang, Tenglong Chen, Xiaochen Gai, Qilin Li, Chunhui Wang, Jia Yao, Yu Liu, Shang Cai, Xiaochun Yu
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-20 (2023)
Abstract The BRCA1/BARD1 complex plays a key role in the repair of DNA double-strand breaks (DSBs) in both somatic cells and germ cells. However, the underlying molecular mechanism by which this complex mediates DSB repair is not fully understood. He
Externí odkaz:
https://doaj.org/article/ed5e072cc0664a66957e307fcd589c42
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract In response to genotoxic stress‐induced DNA damage, TopBP1 mediates ATR activation for signaling transduction and DNA damage repair. However, the detailed molecular mechanism remains elusive. Here, using unbiased protein affinity purificat
Externí odkaz:
https://doaj.org/article/48d21b9070334872b0e006d49cfb0c24
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 443 (2023)
The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Machado–Joseph disease (MJD), demands urgent d
Externí odkaz:
https://doaj.org/article/fc87b330b8fd45e3b46429f467a6aeff
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Noncoding RNAs are known to associate with mitotic chromosomes, but the identities and functions of chromosome-associated RNAs in mitosis remain elusive. Here, we show that rRNA species associate with condensed chromosomes during mitosis. In
Externí odkaz:
https://doaj.org/article/e944b9c83ab34b96bc036f8df8cdba7b
Autor:
Xiaochun, Yu
This dissertation explores the application of a chronocoulometric technique to probe cholesterol efflux from the plasma membrane of human mucosa cells, which is the first measurement of its kind and initial human data is provided by Susu Yuan's thesi
Externí odkaz:
http://rave.ohiolink.edu/etdc/view?acc_num=case1432754888
Autor:
Qian Chen, Kai Ma, Xiuhua Liu, Shih-Hsun Chen, Peng Li, Yonghao Yu, Anthony K. L. Leung, Xiaochun Yu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Caspase-mediated cleavage of PARP1 is a surrogate marker for apoptosis. However, the biological significance of PARP1 cleavage during apoptosis is still unclear. Here, using unbiased protein affinity purification, we show that truncated PARP
Externí odkaz:
https://doaj.org/article/eea60e67368c4ea5af8b3e599a928c31
Autor:
Yaqi Cui, Rong Xie, Xuefang Zhang, Yi Liu, Yixuan Hu, Yuan Li, Xiuhua Liu, Xiaochun Yu, Chen Wu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Abstract Accumulated evidence shows that OGT-mediated O-GlcNAcylation plays an important role in response to DNA damage repair. However, it is unclear if the “eraser” O-GlcNAcase (OGA) participates in this cellular process. Here, we examined the
Externí odkaz:
https://doaj.org/article/9f082f8abcb34785ac8367a0442e5e2d
Autor:
Lili Dai, Xiaochun Yu, Ying Shao, Yali Wang, Zaicun Li, Jiangzhu Ye, Shaoli Bai, Xiaoling Guo, Jianyun Wang, Bin Su, Taiyi Jiang, Tong Zhang, Hao Wu, Sarah Robbins Scott, An Liu, Lijun Sun
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background This paper introduces a comprehensive case management model uniting doctors, nurses, and non-governmental organizations (NGOs) in order to shorten the time from HIV diagnosis to initiation of antiviral therapy, improve patients’
Externí odkaz:
https://doaj.org/article/605930ffea3948f6b52f8d9816b6685e
Publikováno v:
Cell & Bioscience, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repai
Externí odkaz:
https://doaj.org/article/2a13d5da78d44295975f28d98e59cd41