Výsledky vyhledávání - "Xiaochuan Hong"

Akademický článek

Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

Autor: Xinran Wang, Lu Lu, Xiaochuan Hong, Lingling Wu, Chao Yang, You Wang, Wenwen Li, Yuanqin Yang, Dongqing Cao, Wen Di, Liufu Deng

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113712- (2024)

Summary: Adoptive cell therapies are emerging forms of immunotherapy that reprogram T cells for enhanced antitumor responses. Although surface programmed cell death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) engagement inhibits antitumor

Externí odkaz: https://doaj.org/article/c211f961db7e47afa0a8ede41e1bee65

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Akademický článek

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

Autor: Lu Lu, Chao Yang, Xingyue Zhou, Lingling Wu, Xiaochuan Hong, Wenwen Li, Xinran Wang, Yuanqin Yang, Dongqing Cao, Ao Zhang, Wen Di, Liufu Deng

Publikováno v: Cell Reports, Vol 42, Iss 9, Pp 113108- (2023)

Summary: Natural killer (NK) cells are cytotoxic innate lymphocytes that eradicate tumor cells. Inducing durable antitumor immune responses by NK cells represents a major priority of cancer immunotherapy. While cytosolic DNA sensing plays an essentia

Externí odkaz: https://doaj.org/article/44425f5759c74c5aa177f82e54668fa4

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ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

Autor: Lingling Wu, Yuanqin Yang, Dongqing Cao, Chao Yang, Meng Wu, Zhen Zhang, Xinran Wang, Youqiong Ye, Jinmei Li, Hui Xiao, Liufu Deng, Lu Lu, Xiangjiao Meng, Jinming Yu, Jingsi Jin, Jinke Cheng, Xiaochuan Hong, Wenwen Li

Publikováno v: Science Advances

Description
ZBP1-MLKL necroptotic signaling bridges tumor cell damage to antitumor immune responses after radiation.
Necroptosis, a form of regulated necrosis, participates in tumor development and dying cell immunogenicity. However, it rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d4dde9825ef996fa99c9b852dd186b
http://europepmc.org/articles/PMC8494295

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Androgen receptor-mediated CD8

Autor: Chao, Yang, Jingsi, Jin, Yuanqin, Yang, Hongxiang, Sun, Lingling, Wu, Mingyi, Shen, Xiaochuan, Hong, Wenwen, Li, Lu, Lu, Dongqing, Cao, Xinran, Wang, Jing, Sun, Youqiong, Ye, Bing, Su, Liufu, Deng

Publikováno v: Immunity. 55(7)

The incidence and mortality rates of many non-reproductive human cancers are generally higher in males than in females. However, the immunological mechanism underlying sexual differences in cancers remains elusive. Here, we demonstrated that sex-rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d09da26abd5f5f985ea33ffca55c9a2
https://pubmed.ncbi.nlm.nih.gov/36103859

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cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Autor: Chao Yang, Yuanqin Yang, Dongqing Cao, Xinran Wang, Fanlin Li, Xuanming Yang, Juanjuan Lu, Bing Su, Jinke Cheng, Meng Wu, Xiaochuan Hong, Jingsi Jin, Liufu Deng, Lingling Wu, Wen Di, Lu Lu, Wenwen Li

Publikováno v: Science Translational Medicine. 12

Although cGAS-STING-mediated DNA sensing in tumor cells or phagocytes is central for launching antitumor immunity, the role of intrinsic cGAS-STING activation in T cells remains unknown. Here, we observed that peripheral blood CD8+ T cells from patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bea73659bf70659f0815c684620ced9
https://doi.org/10.1126/scitranslmed.aay9013

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