Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Xiaochen Kou"'
Autor:
Jiacheng Shen, Li Wu, Xiaoying Shi, Gang Chen, Tingwei Liu, Fangfang Xu, Xiaocui Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Chenfei Wang, Shaorong Gao, Shaohua Xu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demonstrated unprecedented
Externí odkaz:
https://doaj.org/article/e367f238406e4f54bfee27f6fbbe9a1f
Autor:
Liping Wang, Shanru Yi, Xinyu Cui, Zhenxiang Guo, Mengting Wang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang, Shaorong Gao, Guang Yang, Jiayu Chen, Rui Gao
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114136- (2024)
Summary: Embryos, originating from fertilized eggs, undergo continuous cell division and differentiation, accompanied by dramatic changes in transcription, translation, and metabolism. Chromatin regulators, including transcription factors (TFs), play
Externí odkaz:
https://doaj.org/article/64d3c41a56724e3ca2b643a4eadee1a8
Autor:
Ruimin Xu, Qianshu Zhu, Yuyan Zhao, Mo Chen, Lingyue Yang, Shijun Shen, Guang Yang, Zhifei Shi, Xiaolei Zhang, Qi Shi, Xiaochen Kou, Yanhong Zhao, Hong Wang, Cizhong Jiang, Chong Li, Shaorong Gao, Xiaoyu Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Somatic cell nuclear transfer (SCNT) can be used to reprogram differentiated somatic cells to a totipotent state but has poor efficiency in supporting full-term development. H3K9me3 is considered to be an epigenetic barrier to zygotic genomi
Externí odkaz:
https://doaj.org/article/6fb959c598574da09a642d32cbe6dde1
Autor:
Weina Zhang, Mingzhu Wang, Zhiwei Song, Qianzheng Fu, Jiayu Chen, Weitao Zhang, Shuai Gao, Xiaoxiang Sun, Guang Yang, Qiang Zhang, Jiaqing Yang, Huanyin Tang, Haiyan Wang, Xiaochen Kou, Hong Wang, Zhiyong Mao, Xiaojun Xu, Shaorong Gao, Ying Jiang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.
Externí odkaz:
https://doaj.org/article/83eb13e4527c4628b76f40b9417e2198
Autor:
Jiang Zhu, Kang Chen, Yu H. Sun, Wen Ye, Juntao Liu, Dandan Zhang, Nan Su, Li Wu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Shaorong Gao, Lan Kang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.
Externí odkaz:
https://doaj.org/article/01e01fc540bb45648ec7db6c026a3cc0
Autor:
Dandan Bai, Jin Sun, Chuan Chen, Yanping Jia, Yanhe Li, Kuisheng Liu, Yalin Zhang, Jiqing Yin, Yingdong Liu, Xiaoxiao Han, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Zheng Wang, Miaoxin Chen, Xiaoming Teng, Cizhong Jiang, Shaorong Gao, Wenqiang Liu
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110784- (2022)
Summary: Assisted reproductive technology has been widely applied in the treatment of human infertility. However, accumulating evidence indicates that in vitro fertilization (IVF) is associated with a low pregnancy rate, placental defects, and metabo
Externí odkaz:
https://doaj.org/article/0fb614222063498fa63608c68ffa6fed
Autor:
Yanhe Li, Yuteng Weng, Dandan Bai, Yanping Jia, Yingdong Liu, Yalin Zhang, Xiaochen Kou, Yanhong Zhao, Jingling Ruan, Jiayu Chen, Jiqing Yin, Hong Wang, Xiaoming Teng, Zuolin Wang, Wenqiang Liu, Shaorong Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Injecting Cas9 and gRNA into an animal zygote often produces mosaicism and random biallelic targeting. Here, the authors use pronuclear transfer to reduce mosaicism and selectively target parental alleles.
Externí odkaz:
https://doaj.org/article/cc16067a91c84bc8a8ce6c62671c27c7
Autor:
Mo Chen, Qianshu Zhu, Chong Li, Xiaochen Kou, Yanhong Zhao, Yanhe Li, Ruimin Xu, Lei Yang, Lingyue Yang, Liang Gu, Hong Wang, Xiaoyu Liu, Cizhong Jiang, Shaorong Gao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation
Externí odkaz:
https://doaj.org/article/b2196a5e1c62495396e809c16cfb571f
Autor:
Jin Sun, Weisheng Zheng, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Zehang Liang, Lu Wang, Zihao Zhang, Jing Xiao, Rui Gao, Shaorong Gao, Cizhong Jiang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Trophoblast stem cells (TSCs) are critical to mammalian embryogenesis by providing the cell source of the placenta. TSCs can be derived from trophoblast cells. However, the efficiency of TSC derivation from somatic cell nuclear transfer (NT) blastocy
Externí odkaz:
https://doaj.org/article/8d6c0cdfb8d149e5a131f622b8bfea4f
Autor:
You Wu, Wenqiang Liu, Jiayu Chen, Shuaitong Liu, Mingzhu Wang, Lei Yang, Chuan Chen, Meijie Qi, Yiwen Xu, Zhibin Qiao, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Bin Shen, Jiqing Yin, Hong Wang, Yawei Gao, Shaorong Gao
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2461-2472.e6 (2019)
Summary: The nuclear exosome targeting (NEXT) complex is responsible for specific nuclear RNA degradation in mammalian cells. However, its function in development remains unknown. Here, we find that the depletion of a central factor of the NEXT compl
Externí odkaz:
https://doaj.org/article/99295118c50944cebd3aa44f5232a949