Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Xiaocen Jin"'
Autor:
Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The nucleolus is a liquid-liquid phase separation droplet that dynamically changes under stress. Here, the authors report PQBP5/NOL10 is a critical component of the nucleolus, maintaining its structure and position in the nucleus during osmotic stres
Externí odkaz:
https://doaj.org/article/541954025d9d42c8b967b6b96a1b4020
Autor:
Kyota Fujita, Hidenori Homma, Meihua Jin, Yuki Yoshioka, Xiaocen Jin, Yuko Saito, Hikari Tanaka, Hitoshi Okazawa
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112962- (2023)
Summary: Prion-like protein propagation is considered a common pathogenic mechanism in neurodegenerative diseases. Here we investigate the in vivo propagation pattern and aggregation state of mutant α-synuclein by injecting adeno-associated viral (A
Externí odkaz:
https://doaj.org/article/5beae43f6fbf436a940da83fd9dedfcc
Autor:
Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Brain inflammation generally accelerates neurodegeneration but the mechanisms of this are not fully characterised. Here the authors show that PQBP1 in microglia is important for sensing extrinsic Tau 3 R/4 R proteins and triggers an innate immune res
Externí odkaz:
https://doaj.org/article/a6f77446056c4920834d3c51e49c5a27
Autor:
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E. Bianchi, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Tanaka et al use phosphoproteome analysis of post-mortem Alzheimer’s Disease (AD) brains and identified abnormal phosphorylation of Ku70, which leads to DNA damage and transcriptional repression-induced atypical cell death. In a mouse model of AD,
Externí odkaz:
https://doaj.org/article/fd80c0c5e83d4543afa38997ad8b886c
Autor:
Meihua Jin, Xiaocen Jin, Hidenori Homma, Kyota Fujita, Hikari Tanaka, Shigeo Murayama, Hiroyasu Akatsu, Kazuhiko Tagawa, Hitoshi Okazawa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Jin et al use dynamic molecular network analysis to characterise the phosphoproteome in mouse models of neurodegenerative disease. Analyzing four models of frontotemporal lobar degeneration and four models of Alzheimer’s disease, they observe conse
Externí odkaz:
https://doaj.org/article/d5e02764078f40b4a23cb0a281d050c6
Autor:
Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Shingo Yamada, Xiaocen Jin, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Kazuhiko Tagawa, Naoki Atsuta, Masahisa Katsuno, Naoki Tomita, Katsutoshi Furukawa, Yuko Saito, Takashi Saito, Ayaka Ichise, Shinsuke Shibata, Hiroyuki Arai, Takaomi Saido, Marius Sudol, Shin-ichi Muramatsu, Hideyuki Okano, Elliott J. Mufson, Gen Sobue, Shigeo Murayama, Hitoshi Okazawa
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
The precise mechanisms of neuronal cell death in neurodegeneration are not fully understood. Here the authors show that YAP-mediated neuronal necrosis is increased in pre-symptomatic stages of Alzheimer’s disease and intervention to the necrosis re
Externí odkaz:
https://doaj.org/article/f3578dfd2ff148919a9dde2c540ddafd
Autor:
Gaku Ohtomo, Kanoh Kondo, Katsutoshi Furukawa, Masaaki Waragai, Hidenori Homma, Shinsuke Shibata, Marius Sudol, Shingo Yamada, Hiroyuki Arai, Yuko Saito, Atsushi Iwata, Naoki Atsuta, Xiaocen Jin, Kazuhiko Tagawa, Hikari Tanaka, Ayaka Ichise, Takashi Saito, Masahisa Katsuno, Naoki Tomita, Hideyuki Okano, Kyota Fujita, Shin-ichi Muramatsu, Elliott J. Mufson, Gen Sobue, Hitoshi Okazawa, Shigeo Murayama, Takaomi C. Saido
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-22 (2020)
Nature Communications
Nature Communications
The timing and characteristics of neuronal death in Alzheimer’s disease (AD) remain largely unknown. Here we examine AD mouse models with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine 46 (pSer46-MARCKS),
Autor:
Hitomi Masuda, Teikichi Ikura, Kanoh Kondo, Meihua Jin, Yuki Yoshioka, Hitoshi Okazawa, Yu Yamamori, Shigeo Murayama, Kyota Fujita, Marco E. Bianchi, Sumire Takayama, Yukoh Nakazaki, Rie Tokuyama, Xiaocen Jin, Hidenori Homma, Hikari Tanaka, Kentaro Tomii, Nobutoshi Ito, Kazuhiko Tagawa, Takaomi C. Saido, Takashi Saito
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
Communications Biology
Communications Biology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, whic
Autor:
Hiroki Shiwaku, Meihua Jin, Christian J. F. Bertens, Gaku Ohtomo, Hitoshi Okazawa, Kohei Tsumaki, Gen Sobue, Masaki Sone, Yuki Yoshioka, Takanori Yokota, Aiko Ishiki, Atsushi Iwata, Hikari Tanaka, Kanoh Kondo, Haruhisa Inoue, Naoki Atsuta, Hidenori Homma, Kyota Fujita, Masaaki Waragai, Hiroyasu Akatsu, Xiaocen Jin, Kazuhiko Tagawa, Yong Huang, Katsutoshi Furukawa, Masahisa Katsuno, Hiroyuki Arai
Publikováno v:
Life Science Alliance, 4(7):e202101022. Life Science Alliance LLC
The early-stage pathologies of frontotemporal lobal degeneration (FTLD) remain largely unknown. In VCPT262A-KI mice carrying VCP gene mutation linked to FTLD, insufficient DNA damage repair in neural stem/progenitor cells (NSCs) activated DNA-PK and
Autor:
Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Bertens, Christian J.F., Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota
Publikováno v:
Life Science Alliance; May2021, Vol. 4 Issue 5, p1-23, 23p, 50 Graphs