Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Xiaobo Sheng"'
Autor:
Marta Poblocka, Akang Leonard Bassey, Victoria M. Smith, Marta Falcicchio, Ana Sousa Manso, Mohammad Althubiti, XiaoBo Sheng, Andrew Kyle, Ruth Barber, Mark Frigerio, Salvador Macip
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other age-related pathologies. Consistent with this, clearance of senescent cells can prol
Externí odkaz:
https://doaj.org/article/0025965e081a437187edf55f3e63aa33
Autor:
Nick Evans, Ruslan Grygorash, Paul Williams, Andrew Kyle, Terrence Kantner, Ravindra Pathak, XiaoBo Sheng, Fabio Simoes, Hiteshri Makwana, Ricardo Resende, Elena de Juan, Alan Jenkins, David Morris, Aurelie Michelet, Frances Jewitt, Felicity Rudge, Nicolas Camper, Anaïs Manin, William McDowell, Martin Pabst, Antony Godwin, Mark Frigerio, Matthew Bird
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://doaj.org/article/e322c470d7fb4d25b6de4ac481fa6602
Autor:
Chris E. Cooper, Matthew Bird, XiaoBo Sheng, Ji-Won Choi, Gary G.A. Silkstone, Michelle Simons, Natalie Syrett, Riccardo Piano, Luca Ronda, Stefano Bettati, Gianluca Paredi, Andrea Mozzarelli, Brandon J. Reeder
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule to prevent rapid renal clearance. A common method uses maleimide PEGylation of sulfhydryls
Externí odkaz:
https://doaj.org/article/073ae3b7959c4d84b1030e96331afc8b
Autor:
Yuping Liu, Yang Zhao, Zhonghong Wei, Li Tao, Xiaobo Sheng, Siliang Wang, Jiao Chen, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Aiyun Wang, Wenxing Chen, Yin Lu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 5, Pp 1945-1963 (2018)
Background/Aims: Metastasis is the leading cause resulting in high mortality in triple negative breast cancer (TNBC) patients. Cancer cells are skilled at utilizing thioredoxin (Trx) system as an efficient antioxidant system to counteract oxidative d
Externí odkaz:
https://doaj.org/article/cd6d86908f614fbd940a7d2008665413
Autor:
Yuping Liu, Pingting Zhu, Yingyu Wang, Zhonghong Wei, Li Tao, Zhijie Zhu, Xiaobo Sheng, Siliang Wang, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Lihua Sun, Aiyun Wang, Wenxing Chen, Yin Lu
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123781 (2015)
Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organ
Externí odkaz:
https://doaj.org/article/1ab601cad1cf40bdab14d6f089e53aa3
Autor:
Li Tao, Fangtian Fan, Yuping Liu, Weidong Li, Lei Zhang, Junshan Ruan, Cunsi Shen, Xiaobo Sheng, Zhijie Zhu, Aiyun Wang, Wenxing Chen, Shile Huang, Yin Lu
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81945 (2013)
Xanthatin, a sesquiterpene lactone purified from Xanthium strumarium L., possesses prominent anticancer activity. We found that disruption of GSK3β activity was essential for xanthatin to exert its anticancer properties in non-small cell lung cancer
Externí odkaz:
https://doaj.org/article/37872af0eef8437a81936e3dbc42a199
Autor:
Nick, Evans, Ruslan, Grygorash, Paul, Williams, Andrew, Kyle, Terrence, Kantner, Ravindra, Pathak, XiaoBo, Sheng, Fabio, Simoes, Hiteshri, Makwana, Ricardo, Resende, Elena, de Juan, Alan, Jenkins, David, Morris, Aurelie, Michelet, Frances, Jewitt, Felicity, Rudge, Nicolas, Camper, Anaïs, Manin, William, McDowell, Martin, Pabst, Antony, Godwin, Mark, Frigerio, Matthew, Bird
Publikováno v:
Frontiers in pharmacology. 13
Antibody-drug conjugates (ADCs) have begun to fulfil their promise as targeted cancer therapeutics with ten clinical approvals to date. As the field matures, much attention has focused upon the key factors required to produce safe and efficacious ADC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0c163869b09e4c7d83d87923217ec72
https://pubmed.ncbi.nlm.nih.gov/35784686
https://pubmed.ncbi.nlm.nih.gov/35784686
Autor:
Xiaobo Sheng, Siliang Wang, Zhonghong Wei, Jiao Chen, Yang Zhao, Yuping Liu, Junshan Ruan, Zhaoguo Liu, Yunlong Shan, Wenxing Chen, Yin Lu, Aiyun Wang, Yuzhu Cao, Li Tao
Publikováno v:
Cellular Physiology and Biochemistry, Vol 50, Iss 5, Pp 1945-1963 (2018)
Background/Aims: Metastasis is the leading cause resulting in high mortality in triple negative breast cancer (TNBC) patients. Cancer cells are skilled at utilizing thioredoxin (Trx) system as an efficient antioxidant system to counteract oxidative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d7de2aabcbcccfbf2ec533ffc6a513
https://doi.org/10.1159/000494874
https://doi.org/10.1159/000494874
Autor:
Aiyun Wang, Feng Zhang, Shizhong Zheng, Li Tao, Ling Jiang, Yuzhu Cao, Yin Lu, Tianlu Shi, Lei Zhang, Wenhui Qian, Xiaobo Sheng
Publikováno v:
IUBMB Life. 67:778-788
Cancer related inflammation (CRI) is now recognized as the seventh hallmark in the pathogenesis of many types of malignancies. Paeonol, a natural phenolic component isolated from the root bark of Paeonia moutan, has significant anti-inflammatory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2747c2b8493227820d64615aaec94f64
https://doi.org/10.1002/iub.1435
https://doi.org/10.1002/iub.1435
Autor:
William McDowell, Julia Swierkosz, George Badescu, Andrew F. Kyle, Mark Frigerio, Amrita Abhilash, Ji-Won Choi, Estera Jamieson, Matthew P. Baker, XiaoBo Sheng, Matthew Bird, Penny Bryant, Ruslan Grygorash, Katarzyna Kozakowska, Korinna Henseleit, Rita Tommasi, Vimal Parekh, Kosma Jurlewicz, Karolina Peciak, Emmanuelle Laurine, Martin Pabst, Nicolas Camper, Antony Godwin, Anaïs Manin, Jeff Edwards, David Morris
Publikováno v:
Molecular Pharmaceutics. 12:1872-1879
The conjugation of monomethyl auristatin E (MMAE) to trastuzumab using a reduction bis-alkylation approach that is capable of rebridging reduced (native) antibody interchain disulfide bonds has been previously shown to produce a homogeneous and stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdafeb6a27047bdb000238cba2a009a
https://doi.org/10.1021/acs.molpharmaceut.5b00116
https://doi.org/10.1021/acs.molpharmaceut.5b00116