Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xiaobing Qing"'
Autor:
Xiaoqian Liu, Nadine Schneble-Löhnert, Martina Kristofova, Xiaobing Qing, Jan Labisch, Susanne Hofmann, Sandra Ehrenberg, Mara Sannai, Tjard Jörß, Alessandro Ori, Maren Godmann, Zhao-Qi Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract MCPH1 is a causal gene for the neurodevelopmental disorder, human primary microcephaly (MCPH1, OMIM251200). Most pathogenic mutations are located in the N-terminal region of the gene, which encodes a BRCT domain, suggesting an important func
Externí odkaz:
https://doaj.org/article/6b3b8820958a43f3aa4ddfbfd3afe4eb
Autor:
Mingmei Ding, Xiaobing Qing, Guangyu Zhang, Carolin Baade-Büttner, Ralph Gruber, Haizhen Lu, David O. Ferguson, Christian Geis, Zhao-Qi Wang, Zhong-Wei Zhou
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex compromises cell life. Mutations in MRE11, RAD50, and NBS1 cause huma
Externí odkaz:
https://doaj.org/article/6199f3f37ced4add962da1eb48a5fc24
Autor:
Jonas Walter, Silvia Bolognin, Suresh K. Poovathingal, Stefano Magni, Deborah Gérard, Paul M.A. Antony, Sarah L. Nickels, Luis Salamanca, Emanuel Berger, Lisa M. Smits, Kamil Grzyb, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Jochen Ohnmacht, Michele Bertacchi, Javier Jarazo, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Rejko Krüger, Thomas Sauter, Michèle Studer, Luis Pereira de Almeida, Karl J. Tronstad, Lasse Sinkkonen, Alexander Skupin, Jens C. Schwamborn
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109864- (2021)
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a
Externí odkaz:
https://doaj.org/article/2b9fa19fd71645ae8efd92a4e547da7e
Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming
Autor:
Zhiwei Luo, Xiaobing Qing, Christina Benda, Zhijian Huang, Meng Zhang, Yinghua Huang, Hui Zhang, Lulu Wang, Yiwei Lai, Carl Ward, Giacomo Volpe, Xiaofen Zhong, Baoming Qin, Qiang Zhuang, Miguel A. Esteban, Wenjuan Li
Publikováno v:
Cell Regeneration, Vol 8, Iss 1, Pp 21-29 (2019)
Class IIa histone deacetylases (HDACs) are a subfamily of HDACs with important functions in development and adult tissue homeostasis. As opposed to other HDACs, they lack catalytic function and bind transcription factors to recruit transcriptional co
Externí odkaz:
https://doaj.org/article/294dc3b4102440d68e26f5380b6dcd97
Autor:
Jonas Walter, Silvia Bolognin, Paul M.A. Antony, Sarah L. Nickels, Suresh K. Poovathingal, Luis Salamanca, Stefano Magni, Rita Perfeito, Fredrik Hoel, Xiaobing Qing, Javier Jarazo, Jonathan Arias-Fuenzalida, Tomasz Ignac, Anna S. Monzel, Laura Gonzalez-Cano, Luis Pereira de Almeida, Alexander Skupin, Karl J. Tronstad, Jens C. Schwamborn
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 878-889 (2019)
Summary: Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a crucial cofactor in its etiol
Externí odkaz:
https://doaj.org/article/dc7ad6d0aa01486690395fc84a57c0fb
Autor:
Jonathan Arias-Fuenzalida, Javier Jarazo, Xiaobing Qing, Jonas Walter, Gemma Gomez-Giro, Sarah Louise Nickels, Holm Zaehres, Hans Robert Schöler, Jens Christian Schwamborn
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1423-1431 (2017)
Summary: Genome editing and human induced pluripotent stem cells hold great promise for the development of isogenic disease models and the correction of disease-associated mutations for isogenic tissue therapy. CRISPR-Cas9 has emerged as a versatile
Externí odkaz:
https://doaj.org/article/4f626ffb6db4436f8ea944b20b16e8e0
Autor:
Xiaobing Qing, Jonas Walter, Javier Jarazo, Jonathan Arias-Fuenzalida, Anna-Lena Hillje, Jens C. Schwamborn
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 44-50 (2017)
The p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) has been identified as the most prevalent genetic cause of familial and sporadic Parkinson's disease (PD). The Cre-LoxP recombination system has been used to correct the LRRK2-G2019S m
Externí odkaz:
https://doaj.org/article/fd5abaaaa9a841d087806577035851e5
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The development of new and easy-to-use nucleases, such as CRISPR/Cas9, made tools for gene editing widely accessible to the scientific community. Cas9-based gene editing protocols are robust for creating knock-out models, but the generation of single
Externí odkaz:
https://doaj.org/article/fbe337e3fcdf41c1902a01ac14ec051c
Publikováno v:
The FEBS journalReferences.
The central nervous system is particularly susceptible to DNA repair deficiency, which renders a variety of neurodevelopmental and neurodegenerative disorders in humans. It is generally believed that DNA damage occurs upon repetitive replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5d06a8d504f199189c62f6af189ca4
https://pubmed.ncbi.nlm.nih.gov/35612788
https://pubmed.ncbi.nlm.nih.gov/35612788
Autor:
Kamil Grzyb, Rejko Krüger, Jochen Ohnmacht, Lasse Sinkkonen, Laura Gonzalez-Cano, Tomasz Ignac, Luis Salamanca, Emanuel Berger, Karl Johan Tronstad, Lisa M. Smits, Jens Christian Schwamborn, Paul Antony, Silvia Bolognin, Alexander Skupin, Michèle Studer, Javier Jarazo, Fredrik Hoel, Thomas Sauter, Sarah Louise Nickels, Xiaobing Qing, Anna S. Monzel, Jonas Walter, Rita Perfeito, Deborah Gérard, Luís Pereira de Almeida, Stefano Magni, Michele Bertacchi, Suresh Poovathingal
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109864-(2021)
Cell reports
Cell reports
Increasing evidence suggests that neurodevelopmental alterations might contribute to increase the susceptibility to develop neurodegenerative diseases. We investigate the occurrence of developmental abnormalities in dopaminergic neurons in a model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d0963bff88e50986d632a723edeb86
https://lirias.kuleuven.be/handle/20.500.12942/715986
https://lirias.kuleuven.be/handle/20.500.12942/715986
