Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Xiaobei Hu"'
Autor:
Hanlin Wang, Guanghao Luo, Xiaobei Hu, Gaoya Xu, Tao Wang, Minmin Liu, Xiaohui Qiu, Jianan Li, Jingfeng Fu, Bo Feng, Yutong Tu, Weijuan Kan, Chang Wang, Ran Xu, Yubo Zhou, Jianmin Yang, Jia Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Resistance of FLT3-ITD acute myeloid leukaemia (AML) patients to FLT3 inhibitors (FLT3i) remains an urgent clinical challenge. Here, the authors identify C/EBPα activation as a mechanism of FLT3i resistance and therapeutically target C/EBPα activat
Externí odkaz:
https://doaj.org/article/39f28955f5704c10b57165766afb06cd
Autor:
Lexian Tong, Peipei Wang, Xuemei Li, Xiaowu Dong, Xiaobei Hu, Chang Wang, Tao Liu, Jia Li, Yubo Zhou
Publikováno v:
Journal of Medicinal Chemistry. 65:3229-3248
Herein, we report two promising compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c2952e215d983b5d853a567ca2e7b2
https://doi.org/10.1021/acs.jmedchem.1c01792
https://doi.org/10.1021/acs.jmedchem.1c01792
Autor:
Kailong Jiang, Xuemei Li, Chang Wang, Xiaobei Hu, Peipei Wang, Lexian Tong, Yutong Tu, Beijing Chen, Tingting Jin, Tao Wang, Hanlin Wang, Yubing Han, Renzhao Gui, Jianmin Yang, Tao Liu, Jia Li, Yubo Zhou
Publikováno v:
Leukemia.
FLT3 inhibitors (FLT3i) are widely used for the treatment of acute myeloid leukemia (AML), but adaptive and acquired resistance remains a primary challenge. Inhibitors simultaneously blocking adaptive and acquired resistance are highly demanded. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef2cebe193f730dc9498f3c72d32c0
https://pubmed.ncbi.nlm.nih.gov/36526736
https://pubmed.ncbi.nlm.nih.gov/36526736
Autor:
Shulei Zhu, Jieyu Liu, Donghuai Xiao, Peipei Wang, Jingkun Ma, Xiaobei Hu, Jingfeng Fu, Yubo Zhou, Jia Li, Wei Lu
Publikováno v:
European Journal of Medicinal Chemistry. 243:114786
Proteolysis targeting chimera (PROTAC) technology has received widespread attention in recent years as a promising strategy for drug development. Herein, we report a series of novel Wee1 degraders, which were designed and synthesized based on PROTAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3df7e44688c4190231d6dd8f1bf725
https://doi.org/10.1016/j.ejmech.2022.114786
https://doi.org/10.1016/j.ejmech.2022.114786
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Circadian rhythm can modulate normal activity of humans in adapting to daily environment changes. Mechanical stress loading affects skeletal muscle development and bio-functions. This study aimed to investigate the effects of mechanical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38c949135ebcb3564132f754e25745e
https://doi.org/10.12659/msm.928359
https://doi.org/10.12659/msm.928359
Autor:
Ling-Yan Wu, Jing-Ya Li, Hongcheng Shi, Haowen Jiang, Hongmei Yan, Mingfeng Xia, Yiqiu Zhang, Ya-nan Duan, Xin Gao, Jia Li, Lina Zhang, Yushen Gu, Xiaobei Hu
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 6, Pp 1-18 (2019)
Cell Death and Disease, Vol 10, Iss 6, Pp 1-18 (2019)
Brown adipose tissue (BAT) dissipates metabolic energy and mediates non-shivering thermogenesis, thereby boosting energy expenditure. Increasing BAT mass and activity is expected to be a promising strategy for combating obesity; however, few medicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7cfc576a7dd86e1461922d461c5384
https://doi.org/10.1038/s41419-019-1706-y
https://doi.org/10.1038/s41419-019-1706-y
Autor:
Tingting Jin, Lei Xu, Peipei Wang, Xiaobei Hu, Runyuan Zhang, Zhiqi Wu, Wenxin Du, Weijuan Kan, Kun Li, Chang Wang, Yubo Zhou, Jia Li, Tao Liu
Publikováno v:
Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p15069-15090, 22p
Autor:
Xu Han, Ning Song, Saidahmatov, Abdusaid, Peipei Wang, Yong Wang, Xiaobei Hu, Weijuan Kan, Wei Zhu, Lixin Gao, Mingjie Zeng, Yujie Wang, Chunpu Li, Jia Li, Hong Liu, Yubo Zhou, Jiang Wang
Publikováno v:
Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14647-14663, 17p
Autor:
Shengyun Hu, Kunkun Xia, Xiaobei Huang, Ye Zhao, Qingqing Zhang, Dongdong Huang, Weiyi Xu, Zhengju Chen, Chenfei Wang, Zhiyong Zhang
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Colorectal cancer (CRC) is a major cause of cancer-related deaths in humans, and effective treatments are still needed in clinical practice. Despite significant developments in anticancer drugs and inhibitors, their poor stability, water sol
Externí odkaz:
https://doaj.org/article/59d0033d43be4efe86ea22567de79f46
Publikováno v:
Medical Science Monitor; 1/14/2021, Vol. 27, p1-10, 10p