Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Xiaoan Wu"'
Autor:
Alessia Golluscio, Jodene Eldstrom, Jessica J Jowais, Marta Elena Perez, Kevin Peter Cunningham, Alicia De La Cruz, Xiaoan Wu, Valentina Corradi, D Peter Tieleman, David Fedida, H Peter Larsson
Publikováno v:
eLife, Vol 13 (2024)
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolo
Externí odkaz:
https://doaj.org/article/3b70b86ed7a5417386c6095c41baafa2
Autor:
Yunlong Zhou, Anqi Yu, Xiaoan Wu, Jinjiang Yao, Hao Tan, Huaao Wang, Chengjie Lian, Aiguo Zhou
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background A variety of measurement methods and imaging modalities are in use to quantify the morphology of lateral femoral condyle (LFC), but the most reliable method remains elusive in patients with lateral patellar dislocation (LPD). The
Externí odkaz:
https://doaj.org/article/c2fae70847da49888f357ceb4ce6e06c
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1643-1654 (2023)
Abstract Background Kushenol A is natural flavonoid extract discovered in recent years, with potential anti‐tumor activity. Its role in breast cancer is poorly understood. Methods To investigate biological function of Kushenol A in breast cancer (B
Externí odkaz:
https://doaj.org/article/dec72c9d70e14ebda51dc5b0504f0ad9
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The congenital Long QT Syndrome (LQTS) is an inherited disorder in which cardiac ventricular repolarization is delayed and predisposes patients to cardiac arrhythmias and sudden cardiac death. LQT1 and LQT5 are LQTS variants caused by mutations in KC
Externí odkaz:
https://doaj.org/article/b82245643f194de493efe87c08a421c1
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur
Externí odkaz:
https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
Publikováno v:
eLife, Vol 11 (2022)
Neuronal KCNQ channels mediate the M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However
Externí odkaz:
https://doaj.org/article/6e0a724c2bfb432b97349a719a039847
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/916e39ef8eff457f849713b47ca7bd82
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudde
Externí odkaz:
https://doaj.org/article/e07a4e0605884ed9905949525bae0d17
Autor:
Golluscio, Alessia, Eldstrom, Jodene, Jowais, Jessica J., Perez, Marta Elena, Cunningham, Kevin Peter, De La Cruz, Alicia, Xiaoan Wu, Corradi, Valentina, Tieleman, D. Peter, Fedida, David, Larsson, H. Peter
Publikováno v:
eLife; 10/31/2024, p1-17, 17p
Publikováno v:
Cancer Medicine. 12:1643-1654
Kushenol A is natural flavonoid extract discovered in recent years, with potential anti-tumor activity. Its role in breast cancer is poorly understood.To investigate biological function of Kushenol A in breast cancer (BC), Cell Counting Kit-8 assay,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e523dd51f430afebf4b180e1aff4e3
https://doi.org/10.1002/cam4.4993
https://doi.org/10.1002/cam4.4993