Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Xiaoai Chang"'
Autor:
Suyang Wu, Chen Qiu, Jiahao Ni, Wenli Guo, Jiyuan Song, Xingyin Yang, Yulin Sun, Yanjun Chen, Yunxia Zhu, Xiaoai Chang, Peng Sun, Chunxia Wang, Kai Li, Xiao Han
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Adipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have
Externí odkaz:
https://doaj.org/article/b86d2d085f3a49f4b178a8e67bc984ad
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109540- (2024)
Summary: Chronic inflammation is critical for the initiation and progression of type 2 diabetes mellitus via causing both insulin resistance and pancreatic β cell dysfunction. miR-155, highly expressed in macrophages, is a master regulator of chroni
Externí odkaz:
https://doaj.org/article/e8f1e746496e4af5928d97800e96aa89
Autor:
Tijun Wu, Zhi Cai, Fandi Niu, Bin Qian, Peng Sun, Nan Yang, Jing Pang, Hongliang Mei, Xiaoai Chang, Fang Chen, Yunxia Zhu, Yating Li, Fu-Gen Wu, Yaqin Zhang, Ting Lei, Xiao Han
Publikováno v:
Nutrition & Diabetes, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Background Lentinan (LNT) is a complex fungal component that possesses effective antitumor and immunostimulating properties. However, there is a paucity of studies regarding the effects and mechanisms of LNT on type 1 diabetes. Objective In
Externí odkaz:
https://doaj.org/article/4ea9f7af49534b88bb38da60bf8f8d8b
Autor:
Tijun Wu, Yixue Shao, Xirui Li, Tao Wu, Ling Yu, Jin Liang, Yaru Zhang, Jiahui Wang, Tong Sun, Yunxia Zhu, Xiaoai Chang, Shusen Wang, Fang Chen, Xiao Han
Diabetes is a complex and heterogeneous disorder characterized by chronic hyperglycemia. Its core cause is progressively impaired insulin secretion by pancreatic β-cell failures, usually upon a background of preexisting insulin resistance. Recent st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ddd19a6077261a78550ce1a6071e50
Autor:
Yunxia Zhu, Tong Sun, Fang Chen, Xiaoai Chang, Jiahui Wang, Bin Qian, Yaqin Zhang, Xiao Han, Yang Yang, Peng Sun, Tijun Wu, Nan Yang, Yating Li, Ningyuan Tang
Publikováno v:
Diabetologia. 64:2037-2051
Macrophage levels are elevated in pancreatic islets, and the resulting inflammatory response is a major contributor to beta cell failure during obesity and type 2 diabetes mellitus. Previous studies by us and others have reported that exosomes releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b5004f6427957fe8e705a7a64935b3
https://doi.org/10.1007/s00125-021-05489-1
https://doi.org/10.1007/s00125-021-05489-1
Autor:
Zhoubin Tan, Liang Lu, Zhi Cai, Xiaoai Chang, Xiao Han, Ting Lei, Zhuowei Lei, Zisheng Yan, Yiwei Qi, Xuetao Ji, Xiumei Yin
Publikováno v:
British Journal of Pharmacology. 178:3570-3586
BACKGROUND AND PURPOSE Dopamine agonists targeting D2 receptor have been used for decades in treating pituitary adenomas. There has been little clear evidence implicating the canonical G protein signalling as the mechanism by which D2 receptor suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb38cabfb054006404ac5f2d2201b2d5
https://doi.org/10.1111/bph.15504
https://doi.org/10.1111/bph.15504
Autor:
Jing Pang, Wenyu Dong, Xiao Han, Feng Wang, Ningyuan Tang, Fengming Lin, Weiran Zhang, Ting Lei, Jingjing Wang, Xiaoai Chang, Zhi Cai, Yaqin Zhang, Zhuoying Xie, Bin Qian
Publikováno v:
Journal of Biomedical Nanotechnology. 16:352-363
Pancreatic ductal adenocarcinoma (PDAC) is radioresistant. Due to their strong X-ray absorption capacity, gold nanoparticles (AuNPs) have been used as radiosensitizers for cancer therapeutics. Herein, we describe a novel conjugate complex consisting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95523e15951dfa26d2ca164d0e2f3bd0
https://doi.org/10.1166/jbn.2020.2898
https://doi.org/10.1166/jbn.2020.2898
Autor:
Rongjie Bai, Tao Zhang, Yan Gao, Tingting Shu, Yuncai Zhou, Fuqiang Wang, Xiaoai Chang, Wei Tang, Yunxia Zhu, Xiao Han
Publikováno v:
Endocrine journal. 69(8)
Receptor of advanced glycation end products (RAGE) mediates diverse signal transduction following ligand stimulation and plays an important role in diabetes complications and aging associated disease. We have previously verified that advanced glycati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a9d44fb5a5793998908bcfeaaf5781
https://pubmed.ncbi.nlm.nih.gov/35314532
https://pubmed.ncbi.nlm.nih.gov/35314532
Perfluorooctanoic acid (PFOA), a widely used chemical substance, causes an increased risk of human type 2 diabetes (T2D) through a currently unknown mechanism. The aim of the present study was to investigate whether PFOA regulates the functions of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3394e0e916140f9b4840e2f6ad954d7
https://doi.org/10.21203/rs.3.rs-1022358/v1
https://doi.org/10.21203/rs.3.rs-1022358/v1
Autor:
Wei Tang, Yuqian Yang, Yongkai Yu, Xiao Xiao, Yunxia Zhu, Han Xiao, Zhiyi Shen, Tong Sun, Xiaoai Chang
Publikováno v:
Endocrine. 76(3)
Purpose. - Pancreatic β-cell failure is a central hallmark of the pathogenesis of diabetes mellitus; however, the molecular basis underlying chronic inflammation-caused β-cell failure remains unclear. This study reported here specifically assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55445790da1b708bb0cbbfcfdd931f1e
https://pubmed.ncbi.nlm.nih.gov/35194770
https://pubmed.ncbi.nlm.nih.gov/35194770