Zobrazeno 1 - 10
of 53
pro vyhledávání: '"XiaoOu Mao"'
Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice.
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38932 (2012)
We reported previously that ablation of doublecortin (DCX)-immunopositive newborn neurons in mice worsens anatomical and functional outcome measured 1 day after experimental stroke, but whether this effect persists is unknown. We generated transgenic
Externí odkaz:
https://doaj.org/article/631dd1bf096c4fd08bbe007993fc5835
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46326 (2012)
Depletion of neurogenesis worsens functional outcome in young-adult mice after focal cerebral ischemia, but whether a similar effect occurs in older mice is unknown. Using middle-aged (12-month-old) transgenic (DCX-TK((+))) mice that express herpes s
Externí odkaz:
https://doaj.org/article/750b74dc172a4a9eb70e585fc2cb2b44
Publikováno v:
Neuroscience Letters. 580:182-185
Cardiovascular risk factors appear to influence the risk and progression of neurodegenerative disease, but the mechanisms involved are poorly understood. We investigated the possible involvement of oxidized low-density lipoprotein receptor (LOX-1) an
Autor:
Botao Peng, Lin Xie, Rose B. Greenberg, Jack B. Greenberg, Kunlin Jin, Isabelle Mieling, David A. Greenberg, XiaoOu Mao
Publikováno v:
Vascular Pharmacology. 62:82-87
Endothelial cell (EC) function and susceptibility to vascular disease are regulated by flow; this relationship has been modeled in systemic, but not cerebrovascular, EC culture. We studied the effects of unidirectional flow of medium, produced by orb
Autor:
Kunlin Jin1, XiaoOu Mao1, Lin Xie1, Greenberg, Rose B.1, Botao Peng1, Moore, Alexander1, Greenberg, Maeve B.1, Greenberg, David A.1 dgreenberg@buckinstitute.org
Publikováno v:
Aging Cell. Dec2010, Vol. 9 Issue 6, p1076-1083. 8p. 2 Color Photographs, 2 Graphs.
Autor:
David A. Greenberg, Yong Xin Sun, Lin Xie, Jianping Jia, XiaoOu Mao, Xunming Ji, Veronica Galvan, Kunlin Jin
Publikováno v:
Journal of Alzheimer's Disease. 38:437-444
Mammalian target of rapamycin (mTOR) signaling has been suggested to be effective in modifying cognitive status in animal models of Alzheimer's disease (AD), but little is known about its role in AD patients. We hereby tested whether mTOR signaling w
Autor:
XiaoOu Mao, Qichuan Zhuge, Lin Xie, Xiangdong Wang, Weiming Zheng, Lijie Huang, Kunlin Jin, Chen GouRong, Bei Zhao, Ming Zhong, Zhe Bao Wu
Publikováno v:
Journal of Cellular and Molecular Medicine
Up-regulation of Notch4 was observed in the endothelial cells in the arteriovenous malformations (AVMs) in mice. However, whether Notch4 is also involved in brain AVMs in humans remains unclear. Here, we performed immunohistochemistry on normal brain
Autor:
Kunlin Jin, Jian Feng, Hua Li, Bingyin Wang, XiaoOu Mao, Wenjuan Wang, Yingjuan Ying, Xinxin Jiang, Weiming Hu, Youxin Ye, Mei Jin
Publikováno v:
Human Pathology. 42:1132-1141
Animal studies indicate that adult renal stem/progenitor cells can undergo rapid proliferation in response to renal injury, but whether the same is true in humans is largely unknown. To examine the profile of renal stem/progenitor cells responsible f
Autor:
Rose B. Greenberg, David A. Greenberg, XiaoOu Mao, Maeve B. Greenberg, Botao Peng, Kunlin Jin, Alexander Moore, Lin Xie
Publikováno v:
Aging Cell. 9:1076-1083
Neural precursor cell (NPC) transplantation may have a role in restoring brain function after stroke, but how aging might affect the brain's receptivity to such transplants is unknown. We reported previously that transplantation of human embryonic st
Autor:
David A. Greenberg, XiaoOu Mao, Bin Lai, Xiaomei Wang, Lin Xie, Veronica Galvan, Yaoming Wang, Kunlin Jin, Olivia Gorostiza
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:534-544
Transplantation of neural cells is a potential approach for stroke treatment, but disruption of tissue architecture may limit transplant efficacy. One strategy for enhancing the ability of transplants to restore brain structure and function is to adm