Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Xiao-yang Zhou"'
Autor:
Li-Qun Zhang, Xin-Yue Li, Lian-Guo Chen, Zhe Chen, Ren-Ai Xu, Jian-Chang Qian, Xiao-yang Zhou, Da-Peng Dai, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e28952- (2024)
Amino acid variants in protein may result in deleterious effects on enzymatic activity. In this study we investigate the DNA variants on activity of CYP2B6 gene in a Chinese Han population for potential use in precision medicine. All exons in CYP2B6
Externí odkaz:
https://doaj.org/article/5743bf114bd14db7a0d8f78ea271d104
Autor:
Zheng Yuan, Xin Yu, Siyang Wu, Xiaonan Wu, Qiutao Wang, Wenhao Cheng, Weiyu Hu, Chen Kang, Wei Yang, Yingfei Li, Xiao-Yang Zhou
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and a star medication used to treat non-small-cell lung carcinomas (NSCLCs). It has caused broad public concern that osimertinib has relatively lo
Externí odkaz:
https://doaj.org/article/44685d79e6654697ab04705d2368467e
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Alpelisib, an oral selective and small-molecule phosphoinositide 3-kinase inhibitor, was lately approved in the United States to treat breast cancer. A sensitive method to quantify alpelisib levels in rat plasma on the basis of ultra-performance liqu
Externí odkaz:
https://doaj.org/article/91ae63712cda4957bb5b949d3d971fe7
A Porcine Congenital Single-Sided Deafness Model, Its Population Statistics and Degenerative Changes
Autor:
Wei Ren, Cong Xu, Fan-jun Zheng, Ting-ting Lin, Peng Jin, Yue Zhang, Wei-wei Guo, Chuan-hong Liu, Xiao-yang Zhou, Lu-lu Wang, Yong Wang, Hui Zhao, Shi-ming Yang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectiveTo describe and study the population statistics, hearing phenotype, and pathological changes of a porcine congenital single-sided deafness (CSSD) pedigree.MethodsClick auditory brainstem response (ABR), full-frequency ABR, and distortion pro
Externí odkaz:
https://doaj.org/article/d559126c5933432491810bce6fd14017
Autor:
Xiao-Yang Zhou, Xiang-Ran Lu, Ying-Hui Li, Ya-Qing Ma, Shi-Wen Zhao, Fang Wang, Ren-Ai Xu, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiven
Externí odkaz:
https://doaj.org/article/1c8e15da34954718b93406f2728abe26
Autor:
Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Chemistry Central Journal, Vol 11, Iss 1, Pp 1-7 (2017)
Abstract Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with r
Externí odkaz:
https://doaj.org/article/4a8358317a434bedaa3a94bd723ab404
Autor:
Xiao-Yang Zhou, Xiao-Xia Hu, Chen-Chen Wang, Xiang-Ran Lu, Zhe Chen, Qian Liu, Guo-Xin Hu, Jian-Ping Cai
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Cytochrome P450 3A4 (CYP3A4) enzyme activity is known to show considerable ethnic heterogeneity and inter-individual differences, affecting the outcome of drug treatment. CYP3A4 genetic polymorphisms are believed to be one of the important causes, le
Externí odkaz:
https://doaj.org/article/7306474d650d41a2b902ec0f3b2d9bd1
Publikováno v:
PPAR Research, Vol 2019 (2019)
Background. Oxidative stress, inflammation and cardiac apoptosis were closely involved in doxorubicin (DOX)-induced cardiac injury. Piperine has been reported to suppress inflammatory response and pyroptosis in macrophages. However, whether piperine
Externí odkaz:
https://doaj.org/article/5e8564186d1c47ffbd75a44a6ed433dd
Autor:
Xiao-Yang Zhou, Fa-Ming Zhu, Jian-Ping Li, Wei Mao, De-Mei Zhang, Meng-Li Liu, Ai-Lian Hei, Da-Peng Dai, Ping Jiang, Xiao-Yan Shan, Bo-Wei Zhang, Chuan-Fu Zhu, Jie Shen, Zhi-Hui Deng, Zheng-Lei Wang, Wei-Jian Yu, Qiang Chen, Yan-Hui Qiao, Xiang-Ming Zhu, Rong Lv, Guo-Ying Li, Guo-Liang Li, Heng-Cong Li, Xu Zhang, Bin Pei, Li-Xin Jiao, Gang Shen, Ying Liu, Zhi-Hui Feng, Yu-Ping Su, Zhao-Xia Xu, Wen-Ying Di, Yao-Qin Jiang, Hong-Lei Fu, Xiang-Jun Liu, Xiang Liu, Mei-Zhen Zhou, Dan Du, Qi Liu, Ying Han, Zhi-Xin Zhang, Jian-Ping Cai
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139485 (2015)
Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for hematopoietic malignant diseases and numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only faci
Externí odkaz:
https://doaj.org/article/f180aa03f1da49479a5e5736422a03d1
Autor:
Yong Wang, Xiao-Yang Zhou, Peng-Ying Xiang, Lu-Lu Wang, Huan Tang, Fei Xie, Liang Li, Hong Wei
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108347 (2014)
The meganuclease I-SceI has been effectively used to facilitate transgenesis in fish eggs for nearly a decade. I-SceI-mediated transgenesis is simply via embryo cytoplasmic microinjection and only involves plasmid vectors containing I-SceI recognitio
Externí odkaz:
https://doaj.org/article/b5a373daa5b54e6eb0f788470986a026