Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Xiao-ou Zhang"'
Autor:
Ya Zhang, Xiao-Ou Zhang
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36988- (2024)
Background: Circular RNAs (circRNAs) are emerging as potential therapeutic targets for ischemic stroke (IS) due to their regulatory roles in inflammation and apoptosis. This study aimed to develop a comprehensive and robust IS-specific competing endo
Externí odkaz:
https://doaj.org/article/a3672b62f0444045ba4d0a7135f98e1e
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Allele-specific binding (ASB) events occur when transcription factors (TFs) bind more favorably to one of the two parental alleles at heterozygous single nucleotide polymorphisms (SNPs). Evidence suggests that ASB events could rev
Externí odkaz:
https://doaj.org/article/ad8dd21843914d2f89c7a7f3accb6c31
Autor:
Lei Huang, Xiao-Ou Zhang, Esteban J. Rozen, Xiaomei Sun, Benjamin Sallis, Odette Verdejo-Torres, Kim Wigglesworth, Daniel Moon, Tingting Huang, John P. Cavaretta, Gang Wang, Lei Zhang, Jason M. Shohet, Mary M. Lee, Qiong Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
‘Protein arginine methyltransferase 5 (PRMT5) is known to regulate the expression of genes involved in metastasis. Here, the authors show that PRMT5 methylates Akt and methylation is required for phosphorylation and activation of Akt; ultimately le
Externí odkaz:
https://doaj.org/article/08beede925d14353979613ff4f723b89
Autor:
Yang Zhang, Tuan M. Nguyen, Xiao-Ou Zhang, Limei Wang, Tin Phan, John G. Clohessy, Pier Paolo Pandolfi
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-22 (2021)
Abstract Short hairpin RNAs (shRNAs) are used to deplete circRNAs by targeting back-splicing junction (BSJ) sites. However, frequent discrepancies exist between shRNA-mediated circRNA knockdown and the corresponding biological effect, querying their
Externí odkaz:
https://doaj.org/article/ddef8dbdffe34aa79a6e85564b8bfeab
Autor:
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
Externí odkaz:
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
Autor:
Krishna S Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A Dokshin, Pranathi M Krishnamurthy, Yeonsoo Yoon, Judith Gallant, Ping Xu, Xiao-Ou Zhang, Ahmet Rasit Ozturk, Masahiro Shin, Feston Idrizi, Pengpeng Liu, Hassan Gneid, Alireza Edraki, Nathan D Lawson, Jaime A Rivera-Pérez, Erik J Sontheimer, Jonathan K Watts, Craig C Mello
Publikováno v:
eLife, Vol 10 (2021)
Nuclease-directed genome editing is a powerful tool for investigating physiology and has great promise as a therapeutic approach to correct mutations that cause disease. In its most precise form, genome editing can use cellular homology-directed repa
Externí odkaz:
https://doaj.org/article/a4d2a8d974e94e189ee441394236bb61
Autor:
Jichuan Cao, Tianxiong Yu, Bo Xu, Zhongren Hu, Xiao-ou Zhang, William E Theurkauf, Zhiping Weng
Publikováno v:
Nucleic Acids Research. 51:2066-2086
Transposons are mobile genetic elements prevalent in the genomes of most species. The distribution of transposons within a genome reflects the actions of two opposing processes: initial insertion site selection, and selective pressure from the host.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::988cd6a3cfb4cac349318f136bb3a420
https://doi.org/10.1093/nar/gkad054
https://doi.org/10.1093/nar/gkad054
Autor:
Haiwei Mou, Jordan L. Smith, Lingtao Peng, Hao Yin, Jill Moore, Xiao-Ou Zhang, Chun-Qing Song, Ankur Sheel, Qiongqiong Wu, Deniz M. Ozata, Yingxiang Li, Daniel G. Anderson, Charles P. Emerson, Erik J. Sontheimer, Melissa J. Moore, Zhiping Weng, Wen Xue
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon skipping or large genomic deletions that delete exons. For example, CRISPR-mediated
Externí odkaz:
https://doaj.org/article/eb5d5328d15c438ebd69f1e862c787e0
Autor:
Shengyi Sun, Qin Zhao, Yiding Zhao, Mengyang Geng, Qing Wang, Qian Gao, Xiao‐Ou Zhang, Wenhao Zhang, Ling Shuai
Publikováno v:
Cell Proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfeff73ad2e061a33c21a9902c04f0b1
https://doi.org/10.1111/cpr.13498
https://doi.org/10.1111/cpr.13498
Autor:
Gen Zhang, Shikui Tu, Tianxiong Yu, Xiao-Ou Zhang, Swapnil S. Parhad, Zhiping Weng, William E. Theurkauf
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3413-3422.e4 (2018)
Summary: In Drosophila, the piRNAs that guide germline transposon silencing are produced from heterochromatic clusters marked by the HP1 homolog Rhino. We show that Rhino promotes cluster transcript association with UAP56 and the THO complex, forming
Externí odkaz:
https://doaj.org/article/e31bb445f28c4d8f88ceacdf809f6d65