Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Xiao-fen Chen"'
Autor:
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-fen Chen, Lige Leng, Yun-wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi Xu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110006- (2024)
Summary: Apolipoprotein E (apoE) plays a crucial role in the pathogenesis of Alzheimer’s disease (AD). Microglia exhibit a substantial upregulation of apoE in AD-associated circumstances, despite astrocytes being the primary source of apoE expressi
Externí odkaz:
https://doaj.org/article/e97f06da8e3f498d90bbf7902b2919a8
Autor:
Rui Liang, Hengjun Rao, Qin Pang, Ruixue Xu, Zhiwei Jiao, Lirong Lin, Li Li, Li Zhong, Yixin Zhang, Yazhen Guo, Nengming Xiao, Shengfa Liu, Xiao-Fen Chen, Xin-zhuan Su, Jian Li
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTCerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum infection with acute brain lesions. Genetic variations in both host and parasite have been associated with susceptibility to CM, but the underlying molecular
Externí odkaz:
https://doaj.org/article/c9f2a970591043c9b6f7daa88b122953
Publikováno v:
Thrombosis Journal, Vol 21, Iss 1, Pp 1-8 (2023)
Abstract Background Cronkhite-Canada syndrome (CCS) is a rare disease characterized by generalized gastrointestinal polyps, ectodermal abnormalities and variable gastrointestinal symptoms. Few cases to date have described complications with deep vein
Externí odkaz:
https://doaj.org/article/7b8f45636c254e87a9f85d0ca7e4f4b0
Autor:
Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Dan Can, Che-Feng Chang, Yun-wu Zhang, Huaxi Xu, Guojun Bu, Li Zhong, Xiao-Fen Chen
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background TREM2 is a microglial receptor genetically linked to the risk for Alzheimer’s disease (AD). The cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2) have emerged as a valuable biomarker for the disease progression in AD an
Externí odkaz:
https://doaj.org/article/859fe1a88caa4d0a92db629f528b1f22
Autor:
Xin-ling MA, Jia LIU, Xiao-fen CHEN, Wei-tao LI, Chun-yu JIANG, Meng WU, Ming LIU, Zhong-pei LI
Publikováno v:
Journal of Integrative Agriculture, Vol 20, Iss 10, Pp 2797-2806 (2021)
Parent materials and the fertility levels of paddy soils are highly variable in subtropical China. Bacterial diversity and community composition play pivotal roles in soil ecosystem processes and functions. However, the effects of parent material and
Externí odkaz:
https://doaj.org/article/591cbbda25a1474986d166f92788d485
Publikováno v:
Journal of Integrative Agriculture, Vol 19, Iss 8, Pp 2116-2126 (2020)
Green manure can be used as a substitute for chemical fertilizer without reducing rice yield. We studied the responses of soil fertility and rice yield to different combinations of Chinese milk vetch (CMV; Astragalus sinicus L.) and chemical fertiliz
Externí odkaz:
https://doaj.org/article/d76e93a40aeb467bb230e874a9d8172a
Autor:
Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia-Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TREM2 is a genetic risk factor for Alzheimer’s disease, and soluble TREM2 (sTREM2) in the CSF correlates with AD progression. Here the authors study the role of sTREM2 in a mouse model of Alzheimer’s disease, and find it reduces amyloid accumulat
Externí odkaz:
https://doaj.org/article/b52435dfcf7a4d5aa13e0d196ad259a1
Autor:
Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. While multiple studies
Externí odkaz:
https://doaj.org/article/f413ba11b8e2416fb1992f25f45c6001
Autor:
Li Zhong, Xiao-Fen Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD) is the most common form of dementia characterized by the deposition of extracellular amyloid-β (Aβ)-containing plaques, the formation of intraneuronal neurofibrillary tangles as well as neuroinflammatory changes. As the k
Externí odkaz:
https://doaj.org/article/b109aa706a624a3c999ff4d34d5c30db
Autor:
Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
DNAX-activating protein of 12 kDa (DAP12) is a signaling adapter protein expressed in cells that participate in innate immune responses. By pairing with different triggering receptors expressed on myeloid cell (TREM) proteins, DAP12 can mediate both
Externí odkaz:
https://doaj.org/article/5a9c7de68c654eacaacd510798f77858