Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Xiao-fei MO"'
Publikováno v:
工程科学学报, Vol 43, Iss 11, Pp 1522-1533 (2021)
Modernization of urban infrastructure is the premise for improving urban operation efficiency. The traditional direct burying method of the municipal public pipeline requires repeated excavation for maintenance, which seriously affects the traffic an
Externí odkaz:
https://doaj.org/article/b34b1f5b62ec4eeaa4b35071f0d1f7ea
Publikováno v:
European Journal of Medicinal Chemistry. 141:1-14
In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for virtual screening. Compound 13 was identified as the lead compound and then systematical structure a
Autor:
Xiao-Li Xu, Qidong You, Yali Li, Xiaojin Zhang, Jinlian Wei, Ying-Rui Yang, Xiao-fei Mo, Guo Xiaoke, Zheng-Yu Jiang
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1737-1746
Hypoxia-inducible factor-1 (HIF-1) as a key mediator in tumor metastasis, angiogenesis, and poor patient prognosis has been recognized as an important cancer drug target. A novel series of N -(benzofuran-5-yl)aromaticsulfonamide derivatives were synt
Publikováno v:
European journal of medicinal chemistry. 137
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common type of pancreatic cancer, and has still been the medicinal mystery. New drugs and treatment strategies are urgently needed. In this study, 32 benzofuran derivatives are designed, synt
Autor:
Jia-Lin Wang, Jinlian Wei, Ying-Rui Yang, Qidong You, Xiao-fei Mo, Zhenwei Yuan, Chao Zhang, Haopeng Sun, Yi-Yue Xie
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(11)
p53-independent malignant cancer is still severe health problem of human beings. HIF-1 pathway is believed to play an important role in the survival and developing progress of such cancers. In the present study, with the aim to inhibit the proliferat