Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Xiao-Xiong Zhou"'
Autor:
Le Sun, Jia-Lin Yuan, Qiu-Cen Chen, Wen-Kang Xiao, Gui-Ping Ma, Jia-Hua Liang, Xiao-Kun Chen, Song Wang, Xiao-Xiong Zhou, Hui Wu, Chuang-Xiong Hong
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
AimThe study (PROSPERO: CRD42021240905) aims to reveal the relationships among red meat, serum lipids and inflammatory biomarkers.Methods and resultsPubMed, EMBASE and the Cochrane databases were explored through December 2021 to identify 574 studies
Externí odkaz:
https://doaj.org/article/f3a742ec995c4357b4e69e11fcaa9a8d
Autor:
Xiao Xiong Zhou, Tao Yan
Publikováno v:
Advanced Materials Research. 1046:440-443
The traditional class naming is take time, the effect is not good, and there will be many take another's place by counterfeiting phenomenon, So, this paper proposes a random naming system based on image processing. This paper establishes the database
Autor:
Krzysztof Felczak, Gian Filippo Ruda, Ganasan Kasinathan, Reto Brun, Marcel Kaiser, Luis M. Ruiz-Pérez, Nils Gunnar Johansson, Xiao Xiong Zhou, Dolores González-Pacanowska, Corinne Nguyen, Ian H. Gilbert, Tadeusz Kulikowski, Christian Sund, Alexander Musso-Buendia, Przemysław Ziemkowski
Publikováno v:
ChemMedChem. 6:309-320
2'-Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum
Autor:
Xiao-Xiong Zhou, Mark D. Smith, Hans Maag, David Bernard Smith, Isabel Najera, Genadiy Kalayanov, Sophie Le Pogam, Tatiana Maltseva, Vincent Leveque, Ann C. Kaiser, Kurt Benkestock, Anna Winqvist, Nils Gunnar Johansson, Steven Swallow, Sonal Rajyaguru, Joseph A. Martin, Christian Sund, Nick Cammack, Klaus Klumpp
Publikováno v:
Journal of Medicinal Chemistry. 52:2971-2978
The discovery of 4'-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC(50) = 1.28 microM), the RNA polymerase encoded by hepatitis C virus (HCV), has
Autor:
Christer Sahlberg, Xiao-Xiong Zhou
Publikováno v:
Anti-Infective Agents in Medicinal Chemistry. 7:101-117
The NNRTIs play an important role in the present therapy against HIV/AIDS. This review discusses the basic principles in the development of NNRTIs for HIV therapy. It also summarizes the NNRTIs in clinical use and the major series of NNRTIs in develo
Autor:
Eddy Littler, Xiao-Xiong Zhou
Publikováno v:
Current Topics in Medicinal Chemistry. 6:851-865
Chronic hepatitis B virus (HBV) infection affects about 400 million people worldwide. The development of nucleoside analogs that inhibit HBV polymerase provides an important approach for treating HBV infection. The approval of lamivudine, adefovir an
Publikováno v:
Pharmacology & Toxicology. 90:297-302
Microdialysis sampling was validated for oral availability studies using ganciclovir (9-(1, 3-dihydroxy-2-propoxymethyl) guanine) and a ganciclovir prodrug (9-(1-L-valyloxy-3-octadecanoyloxy-prop-2-oxymethyl) guanine). Three different techniques were
Autor:
Kenneth Alan Simmen, Tatiana Agback, Michael Pelcman, Herman de Kock, Horst Wähling, Christina Rydegård, Joseph A. Martin, Magnus Nilsson, Pierre Raboisson, Pedro Pinho, Xiao Xiong Zhou, Anna Winqvist, Kurt Benckestock, David Bernard Smith, Mirva Boothee, Christian Sund, Bertil Samuelsson, Lotta Vrang, Åsa Rosenquist, Nils Gunnar Johansson, Anna Karin Gertrud Linnea Belfrage, Sophie Lachau-Durand, Klaus Klumpp, Koen Vandyck, Kristina Wikström, Ylva Terelius, Tim H. M. Jonckers, Tse-I Lin, Genadiy Kalayanov, Anneli Lindqvist
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
4′-Azido-2′-deoxy-2′-methylcytidine ( 14 ) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC 50 value of 1.2 μM and showing moderate in vivo bioavailability in rat ( F = 14%). Here we describe the
Autor:
Paula Sánchez, Beatriz Baragaña, Shirley M. Roberts, Dolores González-Pacanowska, Keith S. Wilson, Reto Brun, Marcel Kaiser, Ian H. Gilbert, Orla McCarthy, Nils Gunnar Johansson, Cristina Bosch-Navarrete, Jean L. Whittingham, Xiao-Xiong Zhou
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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We report a series of β-branched acyclic tritylated deoxyuridine analogues as inhibitors of Plasmodium falciparum deoxyuridine-5′- triphosphate nucleotidohydrolase (PfdUTPase), an enzyme involved in nucleotide metabolism that acts as first line of
Autor:
Veronique Morisson, Xiao-Xiong Zhou, Vincent Leveque, Isabel Najera, Sophie Le Pogam, Mark D. Smith, Genadiy Kalayanov, Hans Maag, Tatiana Maltseva, David Bernard Smith, Joseph A. Martin, Kurt Benkestock, Pedro Pinho, Anna Winqvist, Nick Cammack, Nils Gunnar Johansson, Christian Sund, Steven Swallow, Klaus Klumpp, Sonal Rajyaguru
Publikováno v:
Journal of medicinal chemistry. 52(1)
4'-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of severa