Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Xiao-Rong Peng"'
Autor:
Martin Uhrbom, Lars Muhl, Guillem Genové, Jianping Liu, Henrik Palmgren, Ida Alexandersson, Fredrik Karlsson, Alex-Xianghua Zhou, Sandra Lunnerdal, Sonja Gustafsson, Byambajav Buyandelger, Kasparas Petkevicius, Ingela Ahlstedt, Daniel Karlsson, Leif Aasehaug, Liqun He, Marie Jeansson, Christer Betsholtz, Xiao-Rong Peng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute to the identity of adipose stem cells, including anatomic location, microvascular
Externí odkaz:
https://doaj.org/article/1b79a0f896454151b3ae472ae9fc9feb
Autor:
Kasparas Petkevicius, Henrik Palmgren, Matthew S. Glover, Andrea Ahnmark, Anne-Christine Andréasson, Katja Madeyski-Bengtson, Hiroki Kawana, Erik L. Allman, Delaney Kaper, Martin Uhrbom, Liselotte Andersson, Leif Aasehaug, Johan Forsström, Simonetta Wallin, Ingela Ahlstedt, Renata Leke, Daniel Karlsson, Hernán González-King, Lars Löfgren, Ralf Nilsson, Giovanni Pellegrini, Nozomu Kono, Junken Aoki, Sonja Hess, Grzegorz Sienski, Marc Pilon, Mohammad Bohlooly-Y, Marcello Maresca, Xiao-Rong Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progr
Externí odkaz:
https://doaj.org/article/15464563b39b4d54986a8c040d9d92b8
Autor:
Solveig A. Krapf, Jenny Lund, Hege G. Bakke, Tuula A. Nyman, Stefano Bartesaghi, Xiao-Rong Peng, Arild C. Rustan, G. Hege Thoresen, Eili T. Kase
Publikováno v:
Metabolism Open, Vol 18, Iss , Pp 100234- (2023)
Adipose tissue is one of the main regulative sites for energy metabolism. Excess lipid storage and expansion of white adipose tissue (WAT) is the primary contributor to obesity, a strong predisposing factor for development of insulin resistance. Sent
Externí odkaz:
https://doaj.org/article/ecf8c273e32343c2aa05e45db1565f81
Autor:
Stefano Bartesaghi, Kristina Wallenius, Daniel Hovdal, Mathias Liljeblad, Simonetta Wallin, Niek Dekker, Louise Barlind, Nigel Davies, Frank Seeliger, Maria Sörhede Winzell, Sima Patel, Matt Theisen, Luis Brito, Nils Bergenhem, Shalini Andersson, Xiao-Rong Peng
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 500-513 (2022)
Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show that therapeutic levels of FGF21 were achieved following subcutaneous (s.c.) administration
Externí odkaz:
https://doaj.org/article/870f12a5c5cf429dbef9b12f15e31262
Autor:
Cong Liu, Milena Schönke, Borah Spoorenberg, Joost M Lambooij, Hendrik JP van der Zande, Enchen Zhou, Maarten E Tushuizen, Anne-Christine Andreasson, Andrew Park, Stephanie Oldham, Martin Uhrbom, Ingela Ahlstedt, Yasuhiro Ikeda, Kristina Wallenius, Xiao-Rong Peng, Bruno Guigas, Mariëtte R Boon, Yanan Wang, Patrick CN Rensen
Publikováno v:
eLife, Vol 12 (2023)
Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unrav
Externí odkaz:
https://doaj.org/article/10b3762987d94deeac6dedce6336b7ac
Autor:
Lars Muhl, Guillem Genové, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira V. Chivukula, Åsa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Björkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ
Externí odkaz:
https://doaj.org/article/5f2bea014f994236b4d2abd38b628f2e
Autor:
John Lin, Jing Ouyang, Xiao-Rong Peng, Stéphane Isnard, Brandon Fombuena, Jean-Pierre Routy, Yao-Kai Chen, Peng Lyu
Publikováno v:
Chinese Medical Journal, Vol 133, Iss 11, Pp 1350-1352 (2020)
Externí odkaz:
https://doaj.org/article/f929b77f58ed4bf2a5e98bd71224fe5f
Autor:
Christine Skagen, Tuula A. Nyman, Xiao-Rong Peng, Gavin O'Mahony, Eili Tranheim Kase, Arild Chr Rustan, G. Hege Thoresen
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100039- (2021)
Objective: In vivo studies have reported several beneficial metabolic effects of β-adrenergic receptor agonist administration in skeletal muscle, including increased glucose uptake, fatty acid metabolism, lipolysis and mitochondrial biogenesis. Alth
Externí odkaz:
https://doaj.org/article/1d1379ec24504b57901e8cf3fa14b0bb
Autor:
Jenny Lund, Solveig A. Krapf, Medina Sistek, Hege G. Bakke, Stefano Bartesaghi, Xiao-Rong Peng, Arild C. Rustan, G. Hege Thoresen, Eili T. Kase
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100061- (2021)
Sentrin-specific protease (SENP) 2 has been suggested as a possible novel drug target for the treatment of obesity and type 2 diabetes mellitus after observations of a palmitate-induced increase in SENP2 that lead to increased fatty acid oxidation an
Externí odkaz:
https://doaj.org/article/1aefb167ef6a43069d7e66d63da000b8
Autor:
Abel M. Mengeste, Jenny Lund, Parmeshwar Katare, Roya Ghobadi, Hege G. Bakke, Per Kristian Lunde, Lars Eide, Gavin O’ Mahony, Sven Göpel, Xiao-Rong Peng, Eili Tranheim Kase, G. Hege Thoresen, Arild C. Rustan
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100060- (2021)
Background and objective: A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum Ca2+-ATPase (SERCA) and generating heat from ATP hydrolysis to be a pr
Externí odkaz:
https://doaj.org/article/ca2e8dd4b3ef4e27af96a4d4cc90fef0