Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Xiao-Qiao Hong"'
Autor:
Xiao, Qiao-hong, Xiang, Hao, Tian, Ya-nan, Huang, Jiao-long, Li, Ming-qun, Wang, Pu-qing, Lian, Kai, Yu, Peng-xia, Xu, Meng-yao, Zhang, Ruo-nan, Zhang, Yan, Huang, Jie, Zhang, Wei-cheng, Duan, Peng
Publikováno v:
In Science of the Total Environment 1 December 2024 954
Akademický článek
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Autor:
Cai-Ping Tan, Li Zhang, Jie-Wei Liu, Fang-Xin Wang, Wen-Hua Chen, Xiao-Qiao Hong, Peter J. Sadler, Zong-Wan Mao
Publikováno v:
CCS Chemistry. 4:2409-2419
Chloride is the most abundant anion in living systems. Most natural or synthetic chloride anionophores function via hydrogen-bonding interactions. However, dynamic metal-anion coordination can also...
Publikováno v:
Chinese Chemical Letters. 32:1653-1656
In this paper, we demonstrate that modification of anion-transport active 1,3-bis(benzimidazol-2-yl)benzene with strongly electron-withdrawing trifluoromethyl and nitro groups leads to a dramatic increase in the anionophoric activity, and the activit
Publikováno v:
RSC Advances. 11:3972-3980
A series of squaramido-tethered bisbenzimidazoles were synthesized from the reaction of diethyl squarate with substituted 2-aminomethylbenzimidazoles. These conjugates exhibit moderate binding affinity toward chloride anions. They are able to facilit
Publikováno v:
RSC advances. 12(35)
Lysosomal pH is an important modulator for many cellular processes. An agent that is capable of regulating lysosomal pH may find a wide range of potential applications in the field of biomedicine. In this study, we describe the synthesis of a family
Akademický článek
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Publikováno v:
Future Medicinal Chemistry. 11:1091-1106
Aim: Anion/cation symport across cellular membranes may lead to cell apoptosis and be developed as a strategy for new anticancer drug discovery. Methodology: Four aza-crown ether–squaramide conjugates were synthesized and characterized. Their anion
Publikováno v:
Organic & Biomolecular Chemistry. 16:8025-8029
In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficientl
Publikováno v:
European journal of medicinal chemistry. 184
The balance of normal anion concentrations in cells provides basis for maintaining cellular morphology and function. Disrupting the homeostasis of cellular anions and lysosomal pH, in particular with high selectivity for cancer cells over normal cell