Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Xiao-Ling Cockcroft"'
Autor:
Xiao-Ling Cockcroft, Stephan Karl Zahn, Mark Petronczki, Catherine M. Rogers, Fengling Li, Helmut Berger, Bernadette Sharps, Markus Zeeb, Ralph A. Neumüller, Mark Pearson, Dalia Barsyte-Lovejoy, Teresa Krammer, Oleg Fedorov, Barbara Müllauer, Alexander Weiss-Puxbaum, Kilian Huber, Masoud Vedadi, Magdalena M. Szewczyk, Christopher R. Vakoc, Abdellah Allali-Hassani, Tobias Wunberg, Steven Kennedy, Christoph Reiser, Michael Schleicher, Julian E. Fuchs, Cheryl H. Arrowsmith, Moriz Mayer, Jark Böttcher, Guido Boehmelt, Dietrich Böse, Alexandra Hörmann, Andreas Zoephel, Heribert Arnhof, Sandra Winkler, Darryl B. McConnell, Peter Brown, David Dilworth, Maja Corcokovic, Klaus Rumpel, Thomas Gerstberger, Nikolai Mischerikow, Carrow I. Wells, Ulrich Reiser, Daniela Häring
Publikováno v:
Nature Chemical Biology. 15:822-829
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is encoded by the WHSC1L1 gene located in the 8p11-p12 amplicon, frequently amplified in brea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dc86073fff4580d870ac18a39c74e3
https://doi.org/10.1038/s41589-019-0310-x
https://doi.org/10.1038/s41589-019-0310-x
Autor:
Harald Engelhardt, Xiao-Ling Cockcroft, Leonhard Geist, Bernhard Wolkerstorfer, Darryl B. McConnell, Dirk Kessler, Robert Konrat, Moriz Mayer
Publikováno v:
Journal of Medicinal Chemistry. 60:8708-8715
Fragment-based drug design exploits initial screening of low molecular weight compounds and their concomitant affinity improvement. The multitude of possible chemical modifications highlights the necessity to obtain structural information about the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bb2b2299cd1e3e722c6fdf9517ce2a
https://doi.org/10.1021/acs.jmedchem.7b00845
https://doi.org/10.1021/acs.jmedchem.7b00845
Autor:
Gabriella Siszler, Andreas Bergner, Barbara Müllauer, Andreas Mantoulidis, Laetitia J. Martin, Andreas Gollner, Darryl B. McConnell, Bernhard Wolkerstorfer, Xiao-Ling Cockcroft, Moriz Mayer, Dirk Kessler, Wolfgang Hela, Gerhard Fischer, Roland Kousek
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Natural products have proven to be a rich source of molecular architectures for drugs. Here, an integrated approach to natural product screening is proposed, which uncovered eight new natural product scaffolds for KRAS—the most frequently mutated o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76863501a4fb5d279835adefcd8a8f8
https://pubmed.ncbi.nlm.nih.gov/31231840
https://pubmed.ncbi.nlm.nih.gov/31231840
Autor:
Andreas Gollner, Dirk Kessler, Andreas Mantoulidis, Darryl B. McConnell, Bernhard Wolkerstorfer, Gabriella Siszler, Barbara Müllauer, Andreas Bergner, Roland Kousek, Wolfgang Hela, Laetitia J. Martin, Moriz Mayer, Gerhard Fischer, Xiao-Ling Cockcroft
Publikováno v:
Chemistry – A European Journal. 25:11998-11998
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0442b83d758074e821c739a5fad0548a
https://doi.org/10.1002/chem.201903597
https://doi.org/10.1002/chem.201903597
Autor:
Geist, Leonhard, Mayer, Moriz, Xiao-Ling Cockcroft, Wolkerstorfer, Bernhard, Kessler, Dirk, Engelhardt, Harald, McConnell, Darryl B., Konrat, Robert
Publikováno v:
Journal of Medicinal Chemistry; 11/9/2017, Vol. 60 Issue 21, p8708-8715, 8p
Autor:
Keith A. Menear, Niall M. B. Martin, Claire Adcock, Robert Boulter, Xiao-ling Cockcroft, Louise Copsey, Aaron Cranston, Krystyna J. Dillon, Jan Drzewiecki, Sheila Garman, Sylvie Gomez, Hashim Javaid, Frank Kerrigan, Charlotte Knights, Alan Lau, Vincent M. Loh Jr., Ian T. W. Matthews, Stephen Moore, Mark J. O’Connor, Graeme C. M. Smith
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 20, p6581-6591, 11p