Integrated metabolomics and transcriptomics reveal di(2-ethylhexyl) phthalate-induced mitochondrial dysfunction and glucose metabolism disorder through oxidative stress in rat liver

Autor: Gang Li, Chen-Yang Zhao, Qian Wu, Si-yuan Guan, Hong-Wei Jin, Xiao-Lin Na, Yun-Bo Zhang

Publikováno v: Ecotoxicology and Environmental Safety, Vol 228, Iss , Pp 112988- (2021)

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous pollutant that results in hepatotoxicity. However, an understanding of the systematic mechanism of hepatic injury caused by DEHP remains limited. Here, we performed a comprehensive metabolomics and tr

Externí odkaz: https://doaj.org/article/0e05586acce84a35af33a8cc6fad52d3

Long-term Di-(2-ethylhexyl) phthalate Exposure Disturbs the Lipid Metabolism Profiles and Hepatic Enzymes in Male Rats: A UPLC-MS-based Serum Metabolomics Analysis

Autor: Xin Wen, Dong, Wei Dong, Wu, San Qiao, Yao, Yun Bo, Zhang, Cheng, Wang, Hao Yu, Wu, Xiao Lin, Na

Publikováno v: Biomedical and environmental sciences : BES. 34(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c2a5b96f620a8c85049634dca735a03
https://pubmed.ncbi.nlm.nih.gov/34955154

Urine Metabonomic Analysis of Interventions Effect of Soy Isoflavones on Rats Exposed to Di-(2-ethylhexyl) Phthalate

Autor: Xin Wen, Dong, San Qiao, Yao, Hao Yu, Wu, Yun Bo, Zhang, Cheng, Wang, Xiao Lin, Na, Wei Dong, Wu

Publikováno v: Biomedical and environmental sciences : BES. 33(2)

Di-(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant. As an endocrine disruptor, it seriously threatens human health and ecological environmental safety. This study examines the impact of intervention with soybean isoflavones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9ec14058c7032ee4292ca16389418e4
https://pubmed.ncbi.nlm.nih.gov/32131955

Influence of soy isoflavone on lindane cumulant in sprague-dawley rats

Autor: Yang, Yang, Yun Bo, Zhang, Wei, Sheng, Zheng Hai, Fu, Zhe, Wang, Xiao, Wang, Si Yuan, Guan, Xiao Lin, Na

Publikováno v: Biomedical and environmental sciences : BES. 27(8)

Female Sprague-Dawley rats weighing 60-80 g were given different dosages of soy isoflavones and/or lindane for four weeks. Soy isoflavones was added in feed and lindane was given by oral gavage. We found that soy isoflavones could reduce the level of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3372134ec4a0471c4078e5d937339eb0
https://pubmed.ncbi.nlm.nih.gov/25189611

Aniline Induces Oxidative Stress and Apoptosis of Primary Cultured Hepatocytes

Autor: Yong-Hui Wu, Jia Yu, Li Jia, Yue Wang, Shu-Ying Dong, Xiao-Lin Na, Hong Gao, Hong-Wei Dong

Publikováno v: International Journal of Environmental Research and Public Health
International Journal of Environmental Research and Public Health, Vol 13, Iss 12, p 1188 (2016)
International Journal of Environmental Research and Public Health; Volume 13; Issue 12; Pages: 1188

The toxicity and carcinogenicity of aniline in humans and animals have been well documented. However, the molecular mechanism involved in aniline-induced liver toxicity and carcinogenesis remains unclear. In our research, primary cultured hepatocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa52c0a9f9444d7e0cb10759c80c1dd
https://doi.org/10.3390/ijerph13121188