Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Xiao-Hua Chen"'
Autor:
Jing Gao, Xingyu Jiang, Shumin Lei, Wenhao Cheng, Yi Lai, Min Li, Lei Yang, Peifeng Liu, Xiao-hua Chen, Min Huang, Haijun Yu, Huixiong Xu, Zhiai Xu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The antitumor performance of PROteolysis-TArgeting Chimeras (PROTACs) is limited by its insufficient tumor specificity and poor pharmacokinetics. These disadvantages are further compounded by tumor heterogeneity, especially the presence of c
Externí odkaz:
https://doaj.org/article/6c061b14f9a348ed87e43d42a9d6f18d
Autor:
Hao Hu, Wei Hu, An-Di Guo, Linhui Zhai, Song Ma, Hui-Jun Nie, Bin-Shan Zhou, Tianxian Liu, Xinglong Jia, Xing Liu, Xuebiao Yao, Minjia Tan, Xiao-Hua Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Protein-modifying enzymes regulate the dynamics of myriad post-translational modification (PTM) substrates. Precise characterization of enzyme-substrate associations is essential for the molecular basis of cellular function and phenotype. Me
Externí odkaz:
https://doaj.org/article/8bb6d3a208b74d10b4baab4eeb0afdf9
Autor:
Ke‐Nian Yan, Yong‐Qiang Nie, Jia‐Yu Wang, Guang‐Liang Yin, Qia Liu, Hao Hu, Xiaoxia Sun, Xiao‐Hua Chen
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Proteolysis targeting chimeras (PROTACs) have emerged as a promising strategy for drug discovery and exploring protein functions, offering a revolutionary therapeutic modality. Currently, the predominant approach to PROTACs discovery mainly
Externí odkaz:
https://doaj.org/article/9a0b0ebbbd974090b43ead6d4592e3f7
Autor:
Wei-yan Chen, Zhen-hui Zhang, Yi-chao Wen, Xu-ming Xiong, Feng Zhou, Qilin Yang, Ze-bin Guo, Tian-yu Kong, Wei-xiao Chen, Xiao-hua Chen, Qi-rui Wen, De-liang Wen
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Severe septic cardiomyopathy (SCM) is one of the main causes of refractory septic shock (RSS), with a high mortality. The application of venoarterial extracorporeal membrane oxygenation (ECMO) to support the impaired cardiac function in
Externí odkaz:
https://doaj.org/article/32f2654d19ae4c418b62fac1555b888a
Autor:
Zun-Qiang Zhou, Yi Zhang, Zi-Yang Xu, Xiao-Li Tang, Xiao-Hua Chen, Jiao Guan, Zheng-Yun Zhang
Publikováno v:
Frontiers in Genetics, Vol 14 (2024)
Background: Cholangiocarcinoma is characterized by significant cellular heterogeneity and complex intercellular communication, which contribute to its progression and therapeutic resistance. Therefore, unraveling this complexity is essential for the
Externí odkaz:
https://doaj.org/article/ce9ed5f65fed4edbae71d09443e0330f
Autor:
Ting Yao, Jin‐Mei Chen, Le‐Er Shen, Yong‐Sheng Yu, Zheng‐Hao Tang, Guo‐Qing Zang, Yi Zhang, Xiao‐Hua Chen
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 38, Iss 5, Pp 457-468 (2022)
Abstract Aging is characterized by inevitable organ function decline over time, with consequent body deterioration and increased susceptibility to death. Astragalus polysaccharide (APS) has been reported to have anti‐oxidative, anti‐apoptotic, an
Externí odkaz:
https://doaj.org/article/b0bc20aec22247e2ac424d1b1cb9f5e3
Autor:
An-Di Guo, Dan Wei, Hui-Jun Nie, Hao Hu, Chengyuan Peng, Shao-Tong Li, Ke-Nian Yan, Bin-Shan Zhou, Lei Feng, Chao Fang, Minjia Tan, Ruimin Huang, Xiao-Hua Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Developing new click chemistry reactions for robust molecular assembly remains challenging. Here the authors report a light-induced primary amines and o-nitrobenzyl alcohols photoclick cyclization for rapid and modular functionalization of small mole
Externí odkaz:
https://doaj.org/article/08fb4fa9001b40ff9f94f7eb7bb8e194
Autor:
Fang-hong Zhang, Xiao-hua Chen
Publikováno v:
Journal of Mathematics, Vol 2022 (2022)
In this paper, we investigate the long-time behavior for the nonautonomous semilinear second-order evolution equation ∂2u/∂t2−Δu−Δ∂u/∂t−Δ∂2u/∂t2=ft,ux,t−ρt+gt,x,inτ,∞×Ω with some hereditary characteristics, where Ω is an
Externí odkaz:
https://doaj.org/article/d738fe4199a54db3ab1f0b0c51604195
Autor:
You-Hua Yuan, Jian Liu, Yuan-Gang You, Xiao-Hua Chen, Lian-Chao Yuan, Yan Wen, Huan Ying Li, Ying Zhang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
We aimed to identify an unique host transcriptional signature in peripheral blood mononuclear cells (PBMCs) in response to Mycobacterium leprae antigens to distinguish between patients with leprosy and non-leprosy controls for early diagnosis of the
Externí odkaz:
https://doaj.org/article/e91eed5d02914c9c8e5c53dcc0b608bb
Publikováno v:
Journal of Dental Sciences, Vol 14, Iss 2, Pp 113-118 (2019)
Background/purpose: Ground section is the only way to study tooth enamel, and the conventional methods of making ground sections, grinding by hand or using a hard tissue microtome are either too time consuming or money costing. This study aimed to de
Externí odkaz:
https://doaj.org/article/905e8407aec84a97a5a7e2cb4430ea8d