Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xiao-Hong Jian"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The biosynthesis of the antitumour antibiotic CC-1065 includes formation of a cyclopropane. Here, the authors identify the two enzymes that work together to catalyze this reaction, a radical S-adenosyl-l-methionine enzyme and a methyltransferase, and
Externí odkaz:
https://doaj.org/article/edcd713c52a44ba79dc899e965e8716e
Publikováno v:
Cell chemical biology. 29(4)
Mechercharmycin A (MCM-A) is a marine natural product belonging to a family of polyazole cyclopeptides with remarkable bioactivities and unique structures. Identification, heterologous expression, and genetic characterizations of the MCM biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e522ae449794510701dda0ea56fc3736
https://pubmed.ncbi.nlm.nih.gov/34474009
https://pubmed.ncbi.nlm.nih.gov/34474009
Publikováno v:
SSRN Electronic Journal.
Mechercharmycin (MCM) A is a marine natural product belonging to a family of polyazole cyclopeptides with remarkably biological activity and fascinating structure. Identification, comparative analysis and heterologous expression of the biosynthetic g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1704624d4721dbcea9f408c62c3a6100
https://doi.org/10.2139/ssrn.3821964
https://doi.org/10.2139/ssrn.3821964
Autor:
Xiao-hong Jiang, Li-na Weng
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 2, Pp 116-120 (2024)
ObjectiveTo explore the predictive value of predialysis plasma osmolality for frequent intradialytic hypotension (IDH) in elders on maintenance hemodialysis (MHD).MethodsAccording to whether or not there was frequent IDH, 301 MHD elders were assigned
Externí odkaz:
https://doaj.org/article/db26e038767443e1883f59a0a9129ae6
Autor:
Zeng-Fei Pei, Dehai Li, Hai-Xue Pan, Yinhua Lu, Lei Li, Weihong Jiang, Yue Yin, Gong-Li Tang, Min-Jie Yang, Xiao-Hong Jian
Publikováno v:
Organic & Biomolecular Chemistry. 16:9373-9376
Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a38dc13c78e535b312662836d6c556
https://doi.org/10.1039/c8ob02665c
https://doi.org/10.1039/c8ob02665c
Autor:
Hua Yuan, Gong-Li Tang, Sheng Wu, Xiao-Hong Jian, Juan Zhao, Ling-Yun Wang, Wen-Bing Jin, Yue Yin
Publikováno v:
ACS Chemical Biology. 12:1603-1610
CC-1065 is the first characterized member of a family of naturally occurring antibiotics including yatakemycin and duocarmycins with exceptionally potent antitumor activity. CC-1065 contains three benzodipyrroles (1a-, 1b-, and 1c-) of which the 1a-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bead0ed730bb642f97864bd2564dd4
https://doi.org/10.1021/acschembio.7b00302
https://doi.org/10.1021/acschembio.7b00302
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Cyclopropanation of unactivated olefinic bonds via addition of a reactive one-carbon species is well developed in synthetic chemistry, whereas natural cyclopropane biosynthesis employing this strategy is very limited. Here, we identify a two-componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79285f7e119df60c4b6e7074d999425a
https://pubmed.ncbi.nlm.nih.gov/30018376
https://pubmed.ncbi.nlm.nih.gov/30018376
Publikováno v:
SCIENTIA SINICA Vitae. 45:1027-1039
结构复杂多样的天然产物是现代药物的重要组成部分和新药发现的重要源泉. 天然产物的生物合成研究, 是从基因和蛋白水平阐明天然产物的合成途径, 通过酶催化的化学反应将基因与化合物
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29094a857924b7beff8ffc5cd76e2651
https://doi.org/10.1360/n052015-00049
https://doi.org/10.1360/n052015-00049
Publikováno v:
Angewandte Chemie (International ed. in English). 57(3)
As a commercial antibiotic, bicyclomycin (BCM) is currently the only known natural product targeting the transcription termination factor rho. It belongs to a family of highly functionalized diketopiperazine (DKP) alkaloids and bears a unique O-bridg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34acb0a4cf42044aa55fed9c1ddafcbd
https://pubmed.ncbi.nlm.nih.gov/29194897
https://pubmed.ncbi.nlm.nih.gov/29194897
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8540-8545
Nonribosomal peptide synthetases (NRPSs) usually catalyze the biosynthesis of peptide natural products by sequential selection, activation, and condensation of amino acid precursors. It was reported that some fatty acids, α-ketoacids, and α-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf68ddd2c035ce57fbcd6ff07bead810
https://doi.org/10.1073/pnas.1204232109
https://doi.org/10.1073/pnas.1204232109