Zobrazeno 1 - 10
of 867
pro vyhledávání: '"Xiao-Bing Zhang"'
Autor:
Zhi-Xue Yang, Dong-Hao Deng, Zhu-Ying Gao, Zhi-Kang Zhang, Ya-Wen Fu, Wei Wen, Feng Zhang, Xiang Li, Hua-Yu Li, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The potential for off-target mutations is a critical concern for the therapeutic application of CRISPR-Cas9 gene editing. Current detection methodologies, such as GUIDE-seq, exhibit limitations in oligonucleotide integration efficiency and s
Externí odkaz:
https://doaj.org/article/ca2357b3dbc94140bda92191948be5cd
Autor:
Lili Zhang, Mei Chen, Zhiqiang Wang, Minjuan Zhong, Hong Chen, Ting Li, Linlin Wang, Zhihui Zhao, Xiao-Bing Zhang, Guoliang Ke, Yanlan Liu, Weihong Tan
Publikováno v:
ACS Central Science, Vol 10, Iss 6, Pp 1201-1210 (2024)
Externí odkaz:
https://doaj.org/article/298ab79a3cf545f2948dceabfe3022bc
Autor:
Kai-long YUAN, Jun-chen ZHU, Yue XIE, Hua-bing LIU, Hui-qing JIN, Cui-rong SUN, Xiao-bing ZHANG, Hong-ru FENG, Yuan-jiang PAN
Publikováno v:
Zhipu Xuebao, Vol 45, Iss 3, Pp 375-385 (2024)
Sugar esters in tobacco play an important role as precursors generating tobacco aroma species, and their presence significantly influence the quality of tobacco leaves. Typically present in trace amounts, sugar esters in tobacco exhibit a diverse ran
Externí odkaz:
https://doaj.org/article/c473cf8a5a1941d6958dd482ef9b8e42
Autor:
Juan-Juan Zhao, Xin-Yu Sun, Sai-Ning Tian, Zong-Ze Zhao, Meng-Di Yin, Mei Zhao, Feng Zhang, Si-Ang Li, Zhi-Xue Yang, Wei Wen, Tao Cheng, An Gong, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background CRISPR-Cas9 technology has advanced in vivo gene therapy for disorders like hemophilia A, notably through the successful targeted incorporation of the F8 gene into the Alb locus in hepatocytes, effectively curing this disorder in
Externí odkaz:
https://doaj.org/article/6b00ee3c16a94b60a7273e094f61df57
Autor:
Chi Zhang, Kathy Yuen Yee Chan, Wing Hei Ng, John Tak Kit Cheung, Qiwei Sun, Han Wang, Po Yee Chung, Frankie Wai Tsoi Cheng, Alex Wing Kwan Leung, Xiao-Bing Zhang, Po Yi Lee, Siu Ping Fok, Guanglan Lin, Ellen Ngar Yun Poon, Jian-Hua Feng, Yan-Lai Tang, Xue-Qun Luo, Li-Bin Huang, Wei Kang, Patrick Ming Kuen Tang, Junbin Huang, Chun Chen, Junchao Dong, Ester Mejstrikova, Jiaoyang Cai, Yu Liu, Shuhong Shen, Jun J Yang, Patrick Man Pan Yuen, Chi Kong Li, Kam Tong Leung
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Resistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance co
Externí odkaz:
https://doaj.org/article/b91b2983d67042199d70adb7860fbe66
Autor:
Zi-Jun Quan, Si-Ang Li, Zhi-Xue Yang, Juan-Juan Zhao, Guo-Hua Li, Feng Zhang, Wei Wen, Tao Cheng, Xiao-Bing Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1221-1236 (2023)
To achieve the enormous potential of gene-editing technology in clinical therapies, one needs to evaluate both the on-target efficiency and unintended editing consequences comprehensively. However, there is a lack of a pipelined, large-scale, and eco
Externí odkaz:
https://doaj.org/article/420cff9498ce4ae0b14827b32d3370f6
Autor:
Zhi-Xue Yang, Ya-Wen Fu, Juan-Juan Zhao, Feng Zhang, Si-Ang Li, Mei Zhao, Wei Wen, Lei Zhang, Tao Cheng, Jian-Ping Zhang, Xiao-Bing Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 6, Pp 1206-1220 (2023)
A series of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) systems have been engineered for genome editing. The most widely used Cas9 is SpCas9 from Streptococcus pyogenes and SaCas9 from Staphyl
Externí odkaz:
https://doaj.org/article/dd9a845d89064b8db6bec0665d9eb342
Autor:
Ping-Zhao Liang, Zhe Li, Xing-Xing Zhang, Fei-Yu Yang, Su-Lai Liu, Tian-Bing Ren, Lin Yuan, Xiao-Bing Zhang
Publikováno v:
Chemical & Biomedical Imaging, Vol 2, Iss 3, Pp 185-193 (2023)
Externí odkaz:
https://doaj.org/article/a686a9e9b2854c2d8074b2f9a31e9a58
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Natural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells offer an 'off-the-shelf' solution. Hemato
Externí odkaz:
https://doaj.org/article/447de0e7b36f4117b5a463443db1dadc
Autor:
Yuting Wu, Whitney Lewis, Jing Luen Wai, Mengyi Xiong, Jiao Zheng, Zhenglin Yang, Chloe Gordon, Ying Lu, Siu Yee New, Xiao-Bing Zhang, Yi Lu
Publikováno v:
Chemistry, Vol 5, Iss 3, Pp 1745-1759 (2023)
While fluorescent sensors have been developed for monitoring metal ions in health and diseases, they are limited by the requirement of an excitation light source that can lead to photobleaching and a high autofluorescence background. To address these
Externí odkaz:
https://doaj.org/article/da7810146c0b48398f4d8ab1a6965f6d