Výsledky vyhledávání - "Xiao mei Kobayashi"

The Rat Pig-a Mutation Assay in Single and 28 Day-repeated Dose Study of Cyclophosphamide: The PIGRET Assay Can Detect the In Vivo Mutagenicity Earlier than the RBC Pig-a Assay

Autor: Takafumi Kimoto, Yasuhiro Itano, Daishiro Miura, Satsuki Chikura, Xiao-mei Kobayashi, Yoshinori Kasahara, Kumiko Suzuki-Okada

Publikováno v: Genes and Environment. 36:191-198

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25a6969cdf585283b477c875c433e956
https://doi.org/10.3123/jemsge.2014.025

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Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: Direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression

Autor: Robert H. Heflich, Kumiko Suzuki, Takafumi Kimoto, Daishiro Miura, Xiao mei Kobayashi, Vasily N. Dobrovolsky, Yoshinori Kasahara

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 723:36-42

Our previous rat studies indicate that the endogenous Pig-a gene is a promising reporter of in vivo mutation and potentially useful as the basis for an in vivo genotoxicity assay. The function of the Pig-a protein in the synthesis of glycosylphosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32006ed96c99bdf406d719b29e62a1cb
https://doi.org/10.1016/j.mrgentox.2011.03.016

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Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals

Autor: Xiao-mei Kobayashi, Yoshinori Kasahara, Daishiro Miura, Satsuki Chikura, Yasuhiro Itano, Kumiko Suzuki-Okada, Takafumi Kimoto

Publikováno v: The Journal of toxicological sciences. 37(5)

The Pig-a gene mutation assay using perpherial blood erythrocytes is being investigated as a screening tool for assessing mutagenicity in vivo. In this study, we evaluated two distinct approaches for performing the Pig-a assay in rats. We used antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4bfcb2a96dc31640a33d47f8d08570
https://pubmed.ncbi.nlm.nih.gov/23038003

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Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes

Autor: Satsuki Chikura, Katsuyoshi Horibata, Xiao mei Kobayashi, Yasuhiro Itano, Vasily N. Dobrovolsky, Masamitsu Honma, Daishiro Miura, Robert H. Heflich, Takafumi Kimoto, Kumiko Suzuki, Yoshinori Kasahara

Publikováno v: Environmental and molecular mutagenesis. 52(9)

Recent studies indicate that the Pig-a assay is a promising tool for evaluating in vivo mutagenicity. We have developed novel rat Pig-a assays that facilitate measuring mutant frequencies in two early arising populations of blood cells, bone marrow e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03a367107f110ea693fc78e8901b5ad
https://pubmed.ncbi.nlm.nih.gov/22167888

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Akademický článek

Effective use of the Pig-a gene mutation assay for mutagenicity screening: measuring CD59-deficient red blood cells in rats treated with genotoxic chemicals.

Autor: Takafumi Kimoto¹ t.kimoto@teijin.co.jp, Satsuki Chikura¹, Kumiko Suzuki-Okada¹, Xiao-mei Kobayashi¹, Yasuhiro Itano¹, Daishiro Miura¹, Yoshinori Kasahara¹

Publikováno v: Journal of Toxicological Sciences. Oct2012, Vol. 37 Issue 5, p943-955. 13p.

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