Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy.

Autor: Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China., Xiao MK; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Public Health, Xinxiang Medical University, Xinxiang, Henan, China., Feng YY; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China., Wang XY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Chai YR; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China., Wang TY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.

Publikováno v: Biotechnology journal [Biotechnol J] 2023 Feb; Vol. 18 (2), pp. e2200147. Date of Electronic Publication: 2022 Dec 14.