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Akademický článek

Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.

Autor: Joao Arezes, Monica Costa, Ines Vieira, Vera Dias, Xiao L Kong, Rui Fernandes, Matthijn Vos, Anna Carlsson, Yuri Rikers, Graça Porto, Maria Rangel, Robert C Hider, Jorge P Pinto

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e79870 (2013)

Iron is an essential nutrient in several biological processes such as oxygen transport, DNA replication and erythropoiesis. Plasma iron normally circulates bound to transferrin. In iron overload disorders, however, iron concentrations exceed transfer

Externí odkaz: https://doaj.org/article/03cb88044525494cafe3ffbb64347377

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Glutathione: a key component of the cytoplasmic labile iron pool

Autor: Robert C. Hider, Xiao L. Kong

Publikováno v: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 24(6)

The cytoplasmic labile iron pool supplies iron to the mitochondrion for heme and iron sulfur cluster synthesis and to many cytoplasmic enzymes, thereby controlling numerous metabolic reactions. Surprisingly the chemical nature of this pool has never

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba85778c2da051656648e71e67cbb1d
https://pubmed.ncbi.nlm.nih.gov/21769609

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Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

Autor: Francisco Molina-Holgado, Alessandra Gaeta, Robert J. Williams, Paul T. Francis, Xiao L. Kong, Sarah Fakih, Robert C. Hider, Sarah Salvage

Publikováno v: Bioorganicmedicinal chemistry. 19(3)

A novel class of 2-amido-3-hydroxypyridin-4-one iron chelators is described. These compounds have been designed to behave as suitable molecular probes which will improve our knowledge of the role of iron in neurodegenerative conditions. Neurodegenera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280cd8912cc78a1549ee61251469560
https://pubmed.ncbi.nlm.nih.gov/21236688

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Ga(III) complexes--the effect of metal coordination on potential systemic absorption after topical exposure

Autor: K. Staff, Xiao L. Kong, Robert C. Hider, Marc B. Brown, Stuart A. Jones, Robert P. Chilcott

Publikováno v: Toxicology letters. 202(3)

The handling of elemental gallium is not thought to be harmful, but this assumption does not consider metal coordination which readily occurs in physiological fluids. The aim of this work was to determine Ga(III) coordination behaviour in simple solu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaeebfaac1d5fb1ab7b32627502361b
https://pubmed.ncbi.nlm.nih.gov/21315140

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Amido-3-hydroxypyridin-4-ones as iron(III) ligands

Autor: Dick Van der Helm, Mutlu Dilsiz Aytemir, Robert C. Hider, Xiao L. Kong, Yong M. Ma, Zu D. Liu, Sirivipa Piyamongkol

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 16(21)

The synthesis and physicochemical properties of a range of 2- and 6-amido-3-hydroxypyridin-4-ones are described. All the amido-substituted 3-hydroxypyridin-4-ones have lower pK(a) values than 1,2-dimethyl-3-hydroxypyridin-4-one (deferiprone). This is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab6fc1a8d37d902f14670513023c7f5
https://pubmed.ncbi.nlm.nih.gov/20397153

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