Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Xiao Jing Gu"'
Autor:
Kang‐Fu Yin, Ting Chen, Xiao‐Jing Gu, Wei‐Ming Su, Zheng Jiang, Si‐Jia Lu, Bei Cao, Li‐Yi Chi, Xia Gao, Yong‐Ping Chen
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 4, Pp 1324-1334 (2024)
Abstract Background There are no effective pharmacological treatments for sarcopenia. We aim to identify potential therapeutic targets for sarcopenia by integrating various publicly available datasets. Methods We integrated druggable genome data, cis
Externí odkaz:
https://doaj.org/article/75661d3d8e1643ecb5f7344fa4a900bc
Autor:
Qing-Qing Duan, Han Wang, Wei-Ming Su, Xiao-Jing Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yong-Ping Chen
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targets
Externí odkaz:
https://doaj.org/article/bdfe3d0b6f5e4857bf7c3919efdcff64
Autor:
Kang-Fu Yin, Xiao-Jing Gu, Wei-Ming Su, Ting Chen, Jiang Long, Li Gong, Zhi-Ye Ying, Meng Dou, Zheng Jiang, Qing-Qing Duan, Bei Cao, Xia Gao, Li-Yi Chi, Yong-Ping Chen
Publikováno v:
Heliyon, Vol 10, Iss 8, Pp e27422- (2024)
Background: Recent genetic evidence supports that circulating biochemical and metabolic traits (BMTs) play a causal role in Alzheimer's disease (AD), which might be mediated by changes in brain structure. Here, we leveraged publicly available genome-
Externí odkaz:
https://doaj.org/article/3b7f8f1dd1854d2192a6f50b1b9a1475
Autor:
Xiao-Jing Gu, Wei-Ming Su, Meng Dou, Zheng Jiang, Qing-Qing Duan, Kang-Fu Yin, Bei Cao, Yi Wang, Guo-Bo Li, Yong-Ping Chen
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are available. To find potential
Externí odkaz:
https://doaj.org/article/44610c7bed4e4464b0c13c8a59398f99
Autor:
Yang‐Fan Cheng, Kun‐Cheng Liu, Tian‐Mi Yang, Yi Xiao, Qi‐Rui Jiang, Jing‐Xuan Huang, Sirui Zhang, Qian‐Qian Wei, Ru‐Wei Ou, Chun‐Yu Li, Xiao‐Jing Gu, Jean‐Marc Burgunder, Hui‐Fang Shang
Publikováno v:
Brain and Behavior, Vol 13, Iss 11, Pp n/a-n/a (2023)
Abstract Background and aim Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the c
Externí odkaz:
https://doaj.org/article/8b1ab19aa9d9438da3df0e48b49ceb15
Autor:
Wei-Ming Su, Xiao-Jing Gu, Qing-Qing Duan, Zheng Jiang, Xia Gao, Hui-Fang Shang, Yong-Ping Chen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background The time of survival in patients with amyotrophic lateral sclerosis (ALS) varies greatly, and the genetic factors that contribute to the survival of ALS are not well studied. There is a lack of a comprehensive study to elucidate t
Externí odkaz:
https://doaj.org/article/776eff90d88b4e19b037e31f0c074cb1
Autor:
Qing-Qing Duan, Zheng Jiang, Wei-Ming Su, Xiao-Jing Gu, Han Wang, Yang-Fan Cheng, Bei Cao, Xia Gao, Yi Wang, Yong-Ping Chen
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BackgroundThe etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors.MethodA search of relevant literature from PubMed, Embase,
Externí odkaz:
https://doaj.org/article/8a80bd0baeec453c955399117598fe00
Autor:
Zheng Jiang, Xiao-Jing Gu, Wei-Ming Su, Qing-Qing Duan, Yan-Lin Ren, Ju-Rong Li, Li-Yi Chi, Yi Wang, Bei Cao, Yong-Ping Chen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Evidence from observational studies concerning the causal role of blood pressure (BP) and antihypertensive medications (AHM) on Parkinson’s disease (PD) remains inconclusive. A two-sample Mendelian randomization (MR) study was performed
Externí odkaz:
https://doaj.org/article/4d1d9778cc8445c88b20a6ffe96b23bc
Autor:
Yang-Fan Cheng, Xiao-Jing Gu, Tian-Mi Yang, Qian-Qian Wei, Bei Cao, Yang Zhang, Hui-Fang Shang, Yong-Ping Chen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundAmyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in SOD1 and C9orf72 are the most common in Asian and Caucasian patients with AL
Externí odkaz:
https://doaj.org/article/971a2034f11745e5a55835232c078d5c
Autor:
Zheng Jiang, Xiao-Jing Gu, Wei-Ming Su, Qing-Qing Duan, Jun-Yu Lin, Bei Cao, Hui-Fang Shang, Yong-Ping Chen
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102881- (2022)
CHCHD2 mutations have been reported to cause Parkinson’s disease (PD) by a loss of function in mitochondria. Most reported mutations, however, were missense, which was not the perfect model for a study of haploinsufficiency. Here, a truncated mutat
Externí odkaz:
https://doaj.org/article/92131e5709fd4d38b543195df6ed67e9