Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Autor: Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui

Publikováno v: Frontiers in Bioscience-Landmark, Vol 27, Iss 2, p 048 (2022)

Background: Thymosin-α1 has been implicated into the treatment of novel respiratory virus Coronavirus Disease 2019 (COVID-19), but the underlying mechanisms are still disputable. Aim: Herein we aimed to reveal a previously unrecognized mechanism tha

Externí odkaz: https://doaj.org/article/38d0ec6be2af4a19801f7fac4d2cac43

Macrophages promote anti-androgen resistance in prostate cancer bone disease

Autor: Xue-Feng Li, Cigdem Selli, Han-Lin Zhou, Jian Cao, Shuiqing Wu, Ruo-Yu Ma, Ye Lu, Cheng-Bin Zhang, Bijie Xun, Alyson D. Lam, Xiao-Cong Pang, Anu Fernando, Zeda Zhang, Asier Unciti-Broceta, Neil O. Carragher, Prakash Ramachandran, Neil C. Henderson, Ling-Ling Sun, Hai-Yan Hu, Gui-Bo Li, Charles Sawyers, Bin-Zhi Qian

Publikováno v: Li, X, Selli, C, Zhou, H, Cao, J, Wu, S, Ma, R, Lu, Y, Zhang, C, Xun, B, Lam, A D, Pang, X, Fernando, A, Zhang, Z, Unciti-Broceta, A, Carragher, N O, Ramachandran, P, Henderson, N C, Sun, L, Hu, H, Li, G, Sawyers, C & Qian, B 2023, ' Macrophages promote anti-androgen resistance in prostate cancer bone disease ', Journal of Experimental Medicine, vol. 220, no. 4 . https://doi.org/10.1084/jem.20221007

Metastatic castration-resistant prostate cancer (PC) is the final stage of PC that acquires resistance to androgen deprivation therapies (ADT). Despite progresses in understanding of disease mechanisms, the specific contribution of the metastatic mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26da5f113bef6a77bec6c7bdb241903
https://www.pure.ed.ac.uk/ws/files/328311624/Macrophage_promotion_of_anti_androgen_resistance_in_metastatic_hormone_sensitive_prostate_cancer.pdf

The Two-Way Switch Role of ACE2 in the Treatment of Novel Coronavirus Pneumonia and Underlying Comorbidities

Autor: Yi-Zhun Zhu, Han Xu Zhang, Suguro Rinkiko, Yi Min Cui, Zhi Zhang, Xiao Cong Pang

Publikováno v: Molecules
Molecules, Vol 26, Iss 142, p 142 (2021)

December 2019 saw the emergence of the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has spread across the globe. The high infectivity and ongoing mortality of SARS-CoV-2 emphasize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fdf3f7be5c0fe81c8a01dd85fee392
https://doi.org/10.3390/molecules26010142

[Network pharmacology study of effective constituents of traditional Chinese medicine for Alzheimer’s disease treatment]

Autor: Xiao-cong, Pang, Zhe, Wang, Jian-song, Fang, Wen-wen, Lian, Ying, Zhao, De, Kang, Ai-lin, Liu, Guan-hua, Du

Publikováno v: Yao xue xue bao = Acta pharmaceutica Sinica. 51(5)

This study aims to investigate the network pharmacology of Chinese medicinal formulae for treatment of Alzheimer’s disease.Machine learning algorithms were applied to construct classifiers in predicting the active molecules against 25 key targets t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06dcda4d9bdf185f7caa8991d5fa0060
https://pubmed.ncbi.nlm.nih.gov/29874009

Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury.

Autor: Ping Wu¹, Yu Yan¹, Lin-lin Ma², Bi-yu Hou¹, Yang-yang He^1,3, Li Zhang¹, Zi-ran Niu¹, Jun-ke Song¹, Xiao-cong Pang¹, Xiu-ying Yang¹, Guan-hua Du¹ dugh@imm.ac.cn

Publikováno v: Journal of Biological Chemistry. 10/14/2016, Vol. 291 Issue 42, p22288-22301. 14p.