Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Xianyou, Peng"'
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9334-9343 (2021)
Externí odkaz:
https://doaj.org/article/94ddfa3572394e849609c505085d8fdc
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 14, Pp 9334-9343 (2021)
ACS Omega, Vol 6, Iss 14, Pp 9334-9343 (2021)
Pure antiestrogens, or selective estrogen receptor degraders (SERDs), have proven to be effective in treating breast cancer that has progressed on tamoxifen and/or aromatase inhibitors. However, the only FDA-approved pure antiestrogen, fulvestrant, i
Autor:
Qibin, Su, Erica, Banks, Geraldine, Bebernitz, Kirsten, Bell, Cassandra F, Borenstein, Huawei, Chen, Claudio E, Chuaqui, Nanhua, Deng, Andrew D, Ferguson, Sameer, Kawatkar, Neil P, Grimster, Linette, Ruston, Paul D, Lyne, Jon A, Read, Xianyou, Peng, Xiaohui, Pei, Stephen, Fawell, Zhanlei, Tang, Scott, Throner, Melissa M, Vasbinder, Haoyu, Wang, Jon, Winter-Holt, Richard, Woessner, Allan, Wu, Wenzhan, Yang, Michael, Zinda, Jason G, Kettle
Publikováno v:
Journal of medicinal chemistry. 63(9)
JAK1, JAK2, JAK3, and TYK2 belong to the JAK (Janus kinase) family. They play critical roles in cytokine signaling. Constitutive activation of JAK/STAT pathways is associated with a wide variety of diseases. Particularly, pSTAT3 is observed in respon
Publikováno v:
The Journal of Organic Chemistry. 77:701-703
The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric
Publikováno v:
ChemInform. 43
The reaction is applied to various γ-hydroxy- and γ-amino alkenes to afford the 2-substituted tetrahydrofurans and pyrroles.
Publikováno v:
Organic letters. 13(24)
A chiral phosphoric acid catalyzed enantioselective bromocyclization of olefins is described. Various cis-, trans-, or trisubstituted γ-hydroxy-alkenes and γ-amino-alkenes can cyclize under the reaction conditions to give optically active 2-substit
Publikováno v:
Journal of Organic Chemistry; 1/6/2012, Vol. 77 Issue 1, p701-703, 3p