Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Xianyao Xu"'
Autor:
Tyler L. Stevens, Heather R. Manring, Michael J. Wallace, Aaron Argall, Trevor Dew, Peter Papaioannou, Steve Antwi-Boasiako, Xianyao Xu, Stuart G. Campbell, Fadi G. Akar, Maegen A. Borzok, Thomas J. Hund, Peter J. Mohler, Sara N. Koenig, Mona El Refaey
Publikováno v:
Cells, Vol 11, Iss 19, p 3049 (2022)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Externí odkaz:
https://doaj.org/article/63890685f8b04fc6b2be5d434329bc0f
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219011 (2019)
Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately lead to pathological fibrosis and heart failure. Recent evidence demonstrates that remote (non-infarct) territory fibrosis is a major mechanism for ventr
Externí odkaz:
https://doaj.org/article/54d45ff3fb3c4df6be19f1e8d32844ae
Autor:
Jennifer L. Philip, Md. Abdur Razzaque, Mei Han, Jinju Li, Tiju Theccanat, Xianyao Xu, Shahab A. Akhter
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1579-1589 (2015)
Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive oxygen spec
Externí odkaz:
https://doaj.org/article/c892a2bdb0c24c29b5978cfa0bea31e7
Autor:
Dandan Yang, Xiaoping Wan, Schwieterman, Neill, Cavus, Omer, Kacira, Ege, Xianyao Xu, Laurita, Kenneth R., Wold, Loren E., Hund, Thomas J., Mohler, Peter J., Deschênes, Isabelle, Ji-Dong Fu
Publikováno v:
Circulation: Arrhythmia & Electrophysiology; Jan2024, Vol. 17 Issue 1, p34-48, 15p
Autor:
Devasena Ponnalagu, Shanna Hamilton, Shridhar Sanghvi, Diego Antelo, Neill Schwieterman, Inderjot Hansra, Xianyao Xu, Erhe Gao, John C. Edwards, Shyam S. Bansal, Loren E. Wold, Dmitry Terentyev, Paul M. L. Janssen, Thomas J. Hund, Mahmood Khan, Andrew R. Kohut, Walter J. Koch, Harpreet Singh
Publikováno v:
Science Advances. 8
Mitochondrial-associated membranes (MAMs) are known to modulate organellar and cellular functions and can subsequently affect pathophysiology including myocardial ischemia-reperfusion (IR) injury. Thus, identifying molecular targets in MAMs that regu
Autor:
Tyler L, Stevens, Heather R, Manring, Michael J, Wallace, Aaron, Argall, Trevor, Dew, Peter, Papaioannou, Steve, Antwi-Boasiako, Xianyao, Xu, Stuart G, Campbell, Fadi G, Akar, Maegen A, Borzok, Thomas J, Hund, Peter J, Mohler, Sara N, Koenig, Mona, El Refaey
Publikováno v:
Cells. 11(19)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder characterized by fibro-fatty infiltration with an increased propensity for ventricular arrhythmias and sudden death. Genetic variants in desmosomal genes are associated with ACM. Incomplete
Publikováno v:
Heart Rhythm. 20:S166
Autor:
Michael J. Wallace, Nipun Malhotra, Juan Ignacio Elio Mariángelo, Tyler L. Stevens, Lindsay J. Young, Steve Antwi-Boasiako, Danielle Abdallah, Sarah Sumie Takenaka, Omer Cavus, Nathaniel P. Murphy, Mei Han, Xianyao Xu, Matteo E. Mangoni, Thomas J. Hund, Jason D. Roberts, Sandor Györke, Peter J. Mohler, Mona El Refaey
Publikováno v:
Journal of Biological Chemistry. :104818
Autor:
Dandan Yang, Xiaoping Wang, Feng Tang, Ege Kacira, Xianyao Xu, Neill Schwieterman, Loren E. Wold, Thomas J. Hund, Peter J. Mohler, Isabelle Deschenes, Jidong Fu
Publikováno v:
Heart Rhythm. 20:S140
Autor:
Matthew S. Stratton, Federica Accornero, Bryan A. Whitson, Xianyao Xu, Peter J. Mohler, Anders Schlosser, Grith Lykke Sørensen, William R Lawrence, Jennifer M. Petrosino, Paul M.L. Janssen, Thomas J. Hund, Lisa E. Dorn
Publikováno v:
Circ Res
Dorn, L E, Lawrence, W, Petrosino, J M, Xu, X, Hund, T J, Whitson, B A, Stratton, M S, Janssen, P M L, Mohler, P J, Schlosser, A, Sorensen, G L & Accornero, F 2021, ' Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling ', Circulation Research, vol. 128, no. 6, pp. 723-737 . https://doi.org/10.1161/CIRCRESAHA.120.317146
Dorn, L E, Lawrence, W, Petrosino, J M, Xu, X, Hund, T J, Whitson, B A, Stratton, M S, Janssen, P M L, Mohler, P J, Schlosser, A, Sorensen, G L & Accornero, F 2021, ' Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling ', Circulation Research, vol. 128, no. 6, pp. 723-737 . https://doi.org/10.1161/CIRCRESAHA.120.317146
Rationale: Cardiac hypertrophy, a major risk factor for heart failure, occurs when cardiomyocytes remodel in response to complex signaling induced by injury or cell stress. Although cardiomyocytes are the ultimate effectors of cardiac hypertrophy, no