Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Xianxing Jiang"'
Autor:
Qian Zhao, Jiale Dong, Han Liu, Hui Chen, Huan Yu, Shuyin Ye, Shuangjin Yu, Yu Li, Longhui Qiu, Nazi Song, Hongjiao Xu, Qi Liu, Zhiteng Luo, Yuyi Li, Rui Wang, Guodong Chen, Xianxing Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1283-1301 (2024)
The role of co-agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in chronic kidney disease (CKD) remains unclear. Herein we found that GLP-1R and GCGR expression levels were lower in the kidneys of mice with CKD compa
Externí odkaz:
https://doaj.org/article/aea8bd1cc5cd42f4ac94f66dabd72a9d
Autor:
Xianzhi Wei, Daimin Luo, Haonan Li, Yagang Li, Shizhuo Cen, Min Huang, Xianxing Jiang, Guoping Zhong, Weiwei Zeng
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Plant polysaccharides (PP) demonstrate a diverse array of biological and pharmacological properties. This comprehensive review aims to compile and present the multifaceted roles and underlying mechanisms of plant polysaccharides in various liver dise
Externí odkaz:
https://doaj.org/article/7ecc259c3c2e4d018f17103d0dad3087
Autor:
Nazi Song, Hongjiao Xu, Shuohan Wu, Suijia Luo, Jingyao Xu, Qian Zhao, Rui Wang, Xianxing Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 542-558 (2023)
Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH), is a common hepatic manifestation of metabolic syndrome. However, there are no effective therapy to treat this devastating disease. Accumulating evidence sugges
Externí odkaz:
https://doaj.org/article/3474c8148d594caaad10081729ac633e
Autor:
Nazi Song, Hongjiao Xu, Jiahua Liu, Qian Zhao, Hui Chen, Zhibin Yan, Runling Yang, Zhiteng Luo, Qi Liu, Jianmei Ouyang, Shuohan Wu, Suijia Luo, Shuyin Ye, Runfeng Lin, Xi Sun, Junqiu Xie, Tian Lan, Zhongdao Wu, Rui Wang, Xianxing Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2443-2461 (2022)
Currently, there is still no effective curative treatment for the development of late-stage liver fibrosis. Here, we have illustrated that TB001, a dual glucagon-like peptide-1 receptor/glucagon receptor (GLP-1R/GCGR) agonist with higher affinity tow
Externí odkaz:
https://doaj.org/article/14ff200fa8a24774945a4cfc46602ae3
Autor:
Weiwei Zhu, Xiang Zhen, Jingyuan Wu, Yaping Cheng, Junkai An, Xingyu Ma, Jikun Liu, Yuji Qin, Hao Zhu, Jijun Xue, Xianxing Jiang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF3Et2O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF3·Et2O as the fluorin
Externí odkaz:
https://doaj.org/article/192debc183404b709840ddf4ba15cc9e
Autor:
Zhibin Yan, Dan Wang, Chunmei An, Hongjiao Xu, Qian Zhao, Ying Shi, Nazi Song, Bochuan Deng, Xiaomin Guo, Jing Rao, Lu Cheng, Bangzhi Zhang, Lingyun Mou, Wenle Yang, Xianxing Jiang, Junqiu Xie
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 100-111 (2021)
The antimicrobial peptide APKGVQGPNG (named YD), a natural peptide originating from Bacillus amyloliquefaciens CBSYD1, exhibited excellent antibacterial and antioxidant properties in vitro. These characteristics are closely related to inflammatory re
Externí odkaz:
https://doaj.org/article/b69642113f604872933db2ca3bcfaa93
Autor:
Hongjiao Xu, Qian Zhao, Nazi Song, Zhibin Yan, Runfeng Lin, Shuohan Wu, Lili Jiang, Sihua Hong, Junqiu Xie, Huihao Zhou, Rui Wang, Xianxing Jiang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nonalcoholic steatohepatitis (NASH) and associated liver fibrosis have limited therapy options. Here the authors report a novel adiponectin-based dual agonist for adiponectin receptors 1 and 2 with a longer half-life, and show that it ameliorates NAS
Externí odkaz:
https://doaj.org/article/14a1b270a4d24c8f81f31ac78a992843
Autor:
Hongjiao Xu, Qian Zhao, Nazi Song, Zhibin Yan, Runfeng Lin, Shuohan Wu, Lili Jiang, Sihua Hong, Junqiu Xie, Huihao Zhou, Rui Wang, Xianxing Jiang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22414-7
Externí odkaz:
https://doaj.org/article/7a99a013399741a28209890b43f6e53a
Autor:
Shaomeng Chen, Xiuman Zhou, Xin Yang, Wanqiong Li, Shuzhen Li, Zheng Hu, Chen Ling, Ranran Shi, Juan Liu, Guanyu Chen, Nazi Song, Xianxing Jiang, Xinghua Sui, Yanfeng Gao
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1373 (2021)
Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However, the overproduction of lactic acid and its inefficiency in cancer therapy limit its application. Here, we demonstrate the synergistic effects of the lactate/GPR
Externí odkaz:
https://doaj.org/article/705c221a64334d23bf9ca2e8a6b31f90
Autor:
Bai Li, Xian‐Hao Zhou, Peng‐Yu Yang, Liping Zhu, Yuan Zhong, Zhengjun Cai, Biao Jiang, Xiaoqing Cai, Jia Liu, Xianxing Jiang
Publikováno v:
Advanced Science, Vol 6, Iss 13, Pp n/a-n/a (2019)
Abstract Fluorogenic labeling enables imaging cellular molecules of interest with minimal background. This process is accompanied with the notable increase of the quantum yield of fluorophore, thus minimizing the background signals from unactivated p
Externí odkaz:
https://doaj.org/article/97b9467cf8924621be5f67f495be7bdb