Zobrazeno 1 - 10
of 323
pro vyhledávání: '"Xianting Li"'
Autor:
Xingjian Li, Hanwen Zhu, Bik Tzu Huang, Xianting Li, Heesoo Kim, Haiyan Tan, Yuanxi Zhang, Insup Choi, Junmin Peng, Pingyi Xu, Ji Sun, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases, and their phosphorylation levels are elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the LRRK2-regulated RAB
Externí odkaz:
https://doaj.org/article/c6642f6ccf0b48588573ea27ac7e5236
Autor:
Xiaoting Zhou, You-Kyung Lee, Xianting Li, Henry Kim, Carlos Sanchez-Priego, Xian Han, Haiyan Tan, Suiping Zhou, Yingxue Fu, Kerry Purtell, Qian Wang, Gay R. Holstein, Beisha Tang, Junmin Peng, Nan Yang, Zhenyu Yue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human n
Externí odkaz:
https://doaj.org/article/71903ec458994596b1e2fc44fc246235
Publikováno v:
Frontiers in Built Environment, Vol 7 (2021)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is spreading globally, and its high transmission speed and mortality rate are severely interfering with people’s normal lives and the economy. Governments are now reopening their economie
Externí odkaz:
https://doaj.org/article/fe22d1fae0f64b08b06b2f064e15c595
Autor:
Jinglan Zhang, Véronik Lachance, Adam Schaffner, Xianting Li, Anastasia Fedick, Lauren E Kaye, Jun Liao, Jill Rosenfeld, Naomi Yachelevich, Mary-Lynn Chu, Wendy G Mitchell, Richard G Boles, Ellen Moran, Mari Tokita, Elizabeth Gorman, Kaytee Bagley, Wei Zhang, Fan Xia, Magalie Leduc, Yaping Yang, Christine Eng, Lee-Jun Wong, Raphael Schiffmann, George A Diaz, Ruth Kornreich, Ryan Thummel, Melissa Wasserstein, Zhenyu Yue, Lisa Edelmann
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005848 (2016)
Genetic leukoencephalopathies (gLEs) are a group of heterogeneous disorders with white matter abnormalities affecting the central nervous system (CNS). The causative mutation in ~50% of gLEs is unknown. Using whole exome sequencing (WES), we identifi
Externí odkaz:
https://doaj.org/article/58d4941c9bb24969bfbc11da1f857ebc
Publikováno v:
Applied Sciences, Vol 7, Iss 8, p 797 (2017)
Due to the merits of energy saving and environmental protection, the absorption chiller (AC) has attracted a lot of attention, and previous studies only concentrated on the dynamic response of the AC under a single working condition. However, the wor
Externí odkaz:
https://doaj.org/article/232a380d8357411d9126a00fa1f4d452
Autor:
Chong Shen, Xianting Li
Publikováno v:
Energies, Vol 10, Iss 3, p 366 (2017)
Generally, Central Asia is typical for regions with strong solar radiation and various natural cooling sources. The heat gain from the building envelope accounts for a large part of the cooling load there. Thus, the pipe-embedded envelope is receivin
Externí odkaz:
https://doaj.org/article/fccd6effbaeb433489d020ff32f80d2b
Publikováno v:
Advances in Mechanical Engineering, Vol 6 (2014)
Externí odkaz:
https://doaj.org/article/7f306b385e6a4c18a18449e428956fd8
Publikováno v:
Advances in Mechanical Engineering, Vol 5 (2013)
Energy consumption of heating and domestic hot water is very high and will keep increasing. Air source absorption heat pump (ASAHP) was proposed to overcome the problems of low energy efficiency and high air pollution existing in boiler systems, as w
Externí odkaz:
https://doaj.org/article/30080742426149e5af8be4a39b0eb624
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61986 (2013)
Mutations in leucine-rich repeat kinase 2 (LRRK2) underlie an autosomal-dominant form of Parkinson's disease (PD) that is clinically indistinguishable from idiopathic PD. The function of LRRK2 is not well understood, but it has become widely accepted
Externí odkaz:
https://doaj.org/article/9daf2fbd165641e59069ed73200d853a
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17153 (2011)
Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD). The molecular mechanism underlying the pathogenic role of LRRK2 mutations in PD
Externí odkaz:
https://doaj.org/article/619458f46bb24823a815ee8740863489