Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Xiansi, Zhao"'
Supplementary Figures 1-4 from Mechanism of Regulation and Suppression of Melanoma Invasiveness by Novel Retinoic Acid Receptor-γ Target Gene Carbohydrate Sulfotransferase 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b42eec02b5a8beac1fff8b4cac345fe
https://doi.org/10.1158/0008-5472.22377413.v1
https://doi.org/10.1158/0008-5472.22377413.v1
Retinoic acid (RA) induces growth arrest and differentiation of S91 murine melanoma cells and serves as a valuable model for this disease. RA acts through activation of RA receptors (RAR), which are members of the nuclear receptor superfamily of liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8870f69e237267d780a72d75693a5a
https://doi.org/10.1158/0008-5472.c.6498575
https://doi.org/10.1158/0008-5472.c.6498575
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Yana Wang, Xiansi Zhao, Tomoki Yoshihara, Samson King, Ching Kit Chan, Zhong-Hua Yan, Patrick J. LeRoy, Tinh Le, Saurabh Menon
Publikováno v:
SLAS Discovery. 23:656-666
The tedious sample preparation for flow cytometry limits the throughput and thus its usage as a primary screening method despite its sensitivity and accuracy. With the growing focus on utilizing antibodies as a therapeutic modality in drug discovery,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826c1c2d6f68e904072ecd5ce964b9f3
https://doi.org/10.1177/2472555218776607
https://doi.org/10.1177/2472555218776607
Autor:
Stanley C, Xie, David L, Gillett, Natalie J, Spillman, Christopher, Tsu, Madeline R, Luth, Sabine, Ottilie, Sandra, Duffy, Alexandra E, Gould, Paul, Hales, Benjamin A, Seager, Carlie L, Charron, Frank, Bruzzese, Xiaofeng, Yang, Xiansi, Zhao, Shih-Chung, Huang, Craig A, Hutton, Jeremy N, Burrows, Elizabeth A, Winzeler, Vicky M, Avery, Lawrence R, Dick, Leann, Tilley
Publikováno v:
Journal of Medicinal Chemistry
The Plasmodium proteasome represents a potential antimalarial drug target for compounds with activity against multiple life cycle stages. We screened a library of human proteasome inhibitors (peptidyl boronic acids) and compared activities against pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::baa6b25d4621602ea8b6561b2d264873
https://pubmed.ncbi.nlm.nih.gov/30373366
https://pubmed.ncbi.nlm.nih.gov/30373366
Autor:
Xiansi Zhao, Jeffrey R. Patton, Remco A. Spanjaard, Ling Shen, Sajal Ghosh, Nathan Fischel-Ghodsian
Publikováno v:
Molecular Endocrinology. 21:686-699
It was previously shown that mouse Pus1p (mPus1p), a pseudouridine synthase (PUS) known to modify certain transfer RNAs (tRNAs), can also bind with nuclear receptors (NRs) and function as a coactivator through pseudouridylation and likely activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fbaf0255e4b61e0e97318c29fad3c3
https://doi.org/10.1210/me.2006-0414
https://doi.org/10.1210/me.2006-0414
Autor:
Idowu Akinsheye, Ana L. Abujamra, Douglas V. Faller, Remco A. Spanjaard, Xiansi Zhao, Sajal Ghosh
Publikováno v:
Virology. 345:390-403
The long terminal repeat (LTR) region of leukemia viruses plays a critical role in tissue tropism and pathogenic potential of the viruses. We have previously reported that U3-LTR from Moloney murine and feline leukemia viruses (Mo-MuLV and FeLV) upre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bc37092a64f0e8a5bce52d94caec8
https://doi.org/10.1016/j.virol.2005.10.003
https://doi.org/10.1016/j.virol.2005.10.003
Autor:
Remco A. Spanjaard, Xiansi Zhao
Publikováno v:
Journal of Biomedical Science. 10:44-49
Retinoids, such as all-TRANS-retinoic acid (RA), have found applications in several different types of (cancer) therapies. The synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437 or AHPN), an RA receptor (RAR)g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a0daefa102eb3c000ceb004811b8de
https://doi.org/10.1007/bf02255996
https://doi.org/10.1007/bf02255996
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 514:177-192
The aim of this research is to investigate the impact of air pollution on the population in Shanghai. The genotoxicity of extractable organic matter (EOM) from the air particles was investigated by the means of the Salmonella plate incorporation assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492e78b05ab83fc5405c89875784b1de
https://doi.org/10.1016/s1383-5718(01)00338-2
https://doi.org/10.1016/s1383-5718(01)00338-2