Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Xianming Jin"'
Autor:
Lorena Taricani, George Thomas, Yipin Lu, Yue Pan, Patrick J Rudewicz, Robert Elling, Qin Yue, Rama Jain, Jiong Lan, Xiaodong Lin, Janet Sim, Robert J. Aversa, Linda Xiao, Mark Knapp, Paul A. Barsanti, Xianming Jin
Publikováno v:
ACS Medicinal Chemistry Letters. 6:37-41
A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and selective tetrahydropyrazolo[1,5-a]pyrazines. Use of PI3Kα mutants as ATR crystal structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362e1199fdebfa1fcd1c9d5384e24bcc
https://doi.org/10.1021/ml500353p
https://doi.org/10.1021/ml500353p
Autor:
Lina Setti, Robert J. Aversa, Rama Jain, George Thomas, Savithri Ramurthy, Lorena Taricani, Robert Elling, Mark Knapp, Paul A. Barsanti, Yipin Lu, Matthew Cox, Michelle Mathur, Yue Pan, Xianming Jin, Patrick J Rudewicz, Cheng Hu, Michael Patrick Dillon, Qin Yue, Sharadha Subramanian, Jiong Lan, Linda Xiao
Compound 13 was discovered through morphing of the ATR biochemical HTS hit 1. The ABI series was potent and selective for ATR. Incorporation of a 6-azaindole afforded a marked increase in cellular potency but was associated with poor PK and hERG ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afedc70e6a8e79dca0042a4913c70c0a
https://europepmc.org/articles/PMC4291699/
https://europepmc.org/articles/PMC4291699/
