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Akademický článek

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia

Autor: Monica Reis, Gareth R. Willis, Angeles Fernandez-Gonzalez, Vincent Yeung, Elizabeth Taglauer, Margaret Magaletta, Teagan Parsons, Alan Derr, Xianlan Liu, Rene Maehr, Stella Kourembanas, S. Alex Mitsialis

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Treating premature infants with high oxygen is a routine intervention in the context of neonatal intensive care. Unfortunately, the increase in survival rates is associated with various detrimental sequalae of hyperoxia exposure, most notably broncho

Externí odkaz: https://doaj.org/article/48c96b5a14204a3498f375549593d072

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Akademický článek

Therapeutic Effects of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Oxygen-Induced Multi-Organ Disease: A Developmental Perspective

Autor: Angeles Fernandez-Gonzalez, Gareth R. Willis, Vincent Yeung, Monica Reis, Xianlan Liu, S. Alex Mitsialis, Stella Kourembanas

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Despite major advances in neonatal intensive care, infants born at extremely low birth weight still face an increased risk for chronic illness that may persist into adulthood. Pulmonary, retinal, and neurocognitive morbidities associated with preterm

Externí odkaz: https://doaj.org/article/0d6260c31682493faaecf86ef963cd63

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Akademický článek

Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung injury

Autor: Gareth R. Willis, Angeles Fernandez-Gonzalez, Monica Reis, Vincent Yeung, Xianlan Liu, Maria Ericsson, Nick A. Andrews, S. Alex Mitsialis, Stella Kourembanas

Publikováno v: Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)

Early administration of mesenchymal stromal cell (MSC)-derived small extracellular vesicles (MEx) has shown considerable promise in experimental models of bronchopulmonary dysplasia (BPD). However, the ability of MEx to reverse the long-term pulmonar

Externí odkaz: https://doaj.org/article/ba84d02555684ea1b4cff5802b9232f3

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Antenatal Mesenchymal Stromal Cell Extracellular Vesicle Therapy Prevents Preeclamptic Lung Injury in Mice

Autor: Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Lawrence S. Prince, Xianlan Liu, Vincent Yeung, Stella Kourembanas, Gareth R. Willis, Elizabeth S. Taglauer, Monica Reis

Publikováno v: Am J Respir Cell Mol Biol

In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and subsequent fetal growth restriction with significant potential to cause a primary insult to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e46b64e94fcdb49b88279de83d19968
https://doi.org/10.1165/rcmb.2021-0307oc

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Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells

Autor: Xianlan Liu, Angeles Fernandez-Gonzalez, Ali Hashemi Gheinani, Elizabeth S. Taglauer, Gareth R. Willis, S. Alex Mitsialis, Eric Haas, Stella Kourembanas, Maria Ericsson, Monica Reis, Vincent Yeung

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 204:1418-1432

Rationale: Mesenchymal stem/stromal cell (MSC)-small extracellular vesicle (MEx) treatment has shown promise in models of neonatal lung injury. The molecular mechanisms by which MEx afford benefici...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be14c1732983a29179a327fa2bba496d
https://doi.org/10.1164/rccm.202102-0329oc

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Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†

Autor: Xianlan Liu, Stella Kourembanas, Elizabeth S. Taglauer, S. Alex Mitsialis, Angeles Fernandez-Gonzalez, Vincent Yeung, Monica Reis, Gareth R. Willis

Publikováno v: Biol Reprod

Human umbilical cord-derived mesenchymal stromal cells (MSCs) are a widely recognized treatment modality for a variety of preclinical disease models and have been transitioned to human clinical trials. We have previously shown in neonatal lung diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1b40df2fde9fb34f79d07a42d62006
https://doi.org/10.1093/biolre/ioaa198

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