Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Xiankun Cao"'
Autor:
Huidong Wang, Jiadong Guo, Yangzi Yang, Ning Wang, Xiao Yang, Liang Deng, Xiankun Cao, Zhaoyang Ran, Dong Fang, Kang Xu, Yingchun Zhu, Jie Zhao, Jingke Fu, Yongqiang Hao
Publikováno v:
Materials & Design, Vol 239, Iss , Pp 112809- (2024)
With the clinical prevalence of drug-resistant pathogenic bacteria, developing non-antibiotic strategies to treat multi-drug-resistant bacterial infections is urgent yet challenging. Ferroptosis is a non-apoptotic form of regulated cell death that ca
Externí odkaz:
https://doaj.org/article/7c0e098b30384fb5be4e278887ca383e
Autor:
Yating Yu, Kewei Rong, Deqiang Yao, Qing Zhang, Xiankun Cao, Bing Rao, Ying Xia, Yi Lu, Yafeng Shen, Ying Yao, Hongtao Xu, Peixiang Ma, Yu Cao, An Qin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hypophosphatasia (HPP) is a metabolic bone disease that manifests as developmental abnormalities in bone and dental tissues. HPP patients exhibit hypo-mineralization and osteopenia due to the deficiency or malfunction of tissue non-specific
Externí odkaz:
https://doaj.org/article/cedd1e2163b040529844c9efa643d0b7
Autor:
Xin Wang, Tangjun Zhou, Xiao Yang, Xiankun Cao, Gu Jin, Pu Zhang, Jiadong Guo, Kewei Rong, Baixing Li, Yibin Hu, Kexin Liu, Peixiang Ma, An Qin, Jie Zhao
Publikováno v:
Advanced Science, Vol 10, Iss 14, Pp n/a-n/a (2023)
Abstract Chemoresistance is the main obstacle in osteosarcoma (OS) treatment; however, the underlying mechanism remains unclear. In this study, it is discovered that DDRGK domain‐containing protein 1 (DDRGK1) plays a fundamental role in chemoresist
Externí odkaz:
https://doaj.org/article/2bf86d2cdb0f4d85a91a9c4aa3c2be67
Autor:
Xiankun Cao, Wenxin He, Kewei Rong, Shenggui Xu, Zhiqian Chen, Yuwei Liang, Shuai Han, Yifan Zhou, Xiao Yang, Hui Ma, An Qin, Jie Zhao
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background Enhancer of zeste homolog 2 (EZH2) is a novel oncogene that can specifically trimethylate the histone H3 lysine 27 (H3K27me3) to transcriptionally inhibit the expression of downstream tumor-suppressing genes. As a small molecular
Externí odkaz:
https://doaj.org/article/7315dc1134a14d9da225444d4f46fa9e
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundCeritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis. During bone metastasis, tumor cells release factors that
Externí odkaz:
https://doaj.org/article/fc260d0787a3444da328060bdc9fee40
Autor:
Huidong Wang, Xiankun Cao, Jiadong Guo, Xiao Yang, Xiaojiang Sun, Zhiyi Fu, An Qin, Yujie Wu, Jie Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Abnormal activation and overproliferation of osteoclast in inflammatory bone diseases lead to osteolysis and bone mass loss. Although current pharmacological treatments have made extensive advances, limitations still exist. N-[2-bromo-4-(phenylsulfon
Externí odkaz:
https://doaj.org/article/1b2a74b6a25f4d43808b795c31b3598a
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In the field of orthopaedics, bone defects caused by severe trauma, infection, tumor resection, and skeletal abnormalities are very common. However, due to the lengthy and painful process of related surgery, people intend to shorten the recovery peri
Externí odkaz:
https://doaj.org/article/db5f66187005443185d660f9ab2ad32a
Autor:
Tangjun Zhou, Xiao Yang, Zhiqian Chen, Yangzi Yang, Xin Wang, Xiankun Cao, Chen Chen, Chen Han, Haijun Tian, An Qin, Jingke Fu, Jie Zhao
Publikováno v:
Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)
Abstract Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice. This technology m
Externí odkaz:
https://doaj.org/article/263800d9f60545b7a01eed905b60b89d
Autor:
Yichuan Pang, Li Su, Yao Fu, Fan Jia, Chenxi Zhang, Xiankun Cao, Wenxin He, Xueqian Kong, Jiake Xu, Jie Zhao, An Qin
Publikováno v:
Bioactive Materials, Vol 6, Iss 3, Pp 712-720 (2021)
Breast cancer bone metastasis poses significant challenge for therapeutic strategies. Inside the metastatic environment, osteoclasts and tumor cells interact synergistically to promote cancer progression. In this study, the proprotein convertase furi
Externí odkaz:
https://doaj.org/article/fd5abd028c2b4a11aaa4d8acbb5c2e6b
Autor:
Shenggui Xu, Xiankun Cao, Zhenxing Yu, Wenxin He, Yichuan Pang, Wang Lin, Zhiqian Chen, Weizhong Guo, Xiongwei Lu, Chengshou Lin
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorptio
Externí odkaz:
https://doaj.org/article/c8bf445519324e2885e0226ba5dd5fad