Zobrazeno 1 - 10
of 741
pro vyhledávání: '"Xianjun Yu"'
Autor:
Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu, Xianjun Yu
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy remains the standard first-line treatment for pancreatic adenocarcinoma, but with limited efficacy. We aimed to explore the feasibility of adding the PARP inhibitor fuzuloparib to mFOLFIRINOX in the locally advanced/m
Externí odkaz:
https://doaj.org/article/cef3d052c08f444f99a82d9527d12961
Autor:
Mingming Xiao, Jing Yang, Mingwei Dong, Xiaoqi Mao, Haoqi Pan, Yalan Lei, Xuhui Tong, Xiaoning Yu, Xianjun Yu, Si Shi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-16 (2024)
Abstract Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of pancreatic cancer patients have inherent resistance or develop tolerance t
Externí odkaz:
https://doaj.org/article/67c593f6585e478c9e65fdc330dcf273
Autor:
Rong Tang, Zifeng Zhang, Jin Xu, Wei Wang, Qingcai Meng, Yuan Liu, Qiong Du, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1689-1704 (2024)
Background: Mounting evidence underscores the importance of cell communication within the tumor microenvironment, which is pivotal in tumor proliferation, invasion, and metastasis. Exosomes play a crucial role in cell-to-cell communication. Although
Externí odkaz:
https://doaj.org/article/a7c01f957d71404990cf4a4033cc6d8f
Autor:
Jie Chen, Wenming Wu, Chunmei Bai, Yihebali Chi, Li Huo, Liming Jiang, Yuan Ji, Jie Luo, Jie Li, Jingnan Li, Wenhui Lou, Chenghao Shao, Lin Shen, Feng Wang, Yu Wang, Ling Xue, Jin Xu, Chunhui Yuan, Xianjun Yu, Xiaoyu Yin, Hong Zhao, Xiongzeng Zhu, Yupei Zhao
Publikováno v:
Journal of Pancreatology, Vol 7, Iss 2, Pp 97-105 (2024)
The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentia
Externí odkaz:
https://doaj.org/article/f421cf90587443f5bc5768b80042928d
Autor:
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ). However, the biological importance of M
Externí odkaz:
https://doaj.org/article/b9de0dc9db3b4166a7eac67e8116e9ed
Autor:
Qin Dang, Borui Li, Bing Jin, Zeng Ye, Xin Lou, Ting Wang, Yan Wang, Xuan Pan, Qiangsheng Hu, Zheng Li, Shunrong Ji, Chenjie Zhou, Xianjun Yu, Yi Qin, Xiaowu Xu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive
Externí odkaz:
https://doaj.org/article/4f69a13e8cb647ed8701a321ece4ee74
Publikováno v:
Propulsion and Power Research, Vol 13, Iss 1, Pp 118-131 (2024)
Variable cycle engine (VCE) is one of the most promising technologies for the next-generation aircraft, the matching of different components in the compression system is a key difficulty VCE faced. To investigate the component matching mechanisms in
Externí odkaz:
https://doaj.org/article/b6dc8af7747b48c7b3a998df434ca1b4
Autor:
Xiaoqi Mao, Jin Xu, Mingming Xiao, Chen Liang, Jie Hua, Jiang Liu, Wei Wang, Xianjun Yu, Qingcai Meng, Si Shi
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103200- (2024)
Currently, chemotherapy remains occupying a pivotal place in the treatment of pancreatic ductal adenocarcinoma (PDAC). Nonetheless, the emergence of drug resistance in recent years has limited the clinical efficacy of chemotherapeutic agents, especia
Externí odkaz:
https://doaj.org/article/52405a8f56004b489abd69e2f4ca4e76
Autor:
Heng Zhu, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105098- (2024)
Summary: Background: The widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. However, B cell heterogeneity in PDAC remains unexplored. Studying TIL-Bs in PDAC aims to identify new treatment strategi
Externí odkaz:
https://doaj.org/article/1f49f20bec0b41ff810d3b710542204e
Autor:
Zheng Li, Qifeng Zhuo, Borui Li, Mengqi Liu, Chen Chen, Yihua Shi, Wenyan Xu, Wensheng Liu, Shunrong Ji, Xianjun Yu, Xiaowu Xu
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background There is no evidence supporting the feasibility of laparoscopic pancreaticoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD) following neoadjuvant chemotherapy (NACT) for pancreatic ductal adenocarcinoma (PDAC). Meth
Externí odkaz:
https://doaj.org/article/8c6cd877ef3642f99bd6905993b06d56